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Cardiovasc Diabetol:DM或非DM患者,BP-DES vs G2-DES的有效性和安全性

2018-09-07 吴星 环球医学

2018年8月,发表在《Cardiovasc Diabetol》的一项单中心研究调查了糖尿病患者或非糖尿病患者使用生物可降解高分子药物洗脱支架(BP-DESs)vs第二代药物洗脱支架(G2-DESs)的有效性和安全性。

2018年8月,发表在《Cardiovasc Diabetol》的一项单中心研究调查了糖尿病患者或非糖尿病患者使用生物可降解高分子药物洗脱支架(BP-DESs)vs第二代药物洗脱支架(G2-DESs)的有效性和安全性。

背景:改善行经皮冠状动脉介入治疗(PCI)的糖尿病(DM)患者的结局,仍然是临床需要解决的问题。这项研究旨在中国一个单中心中,评价第二代药物洗脱支架(G2-DESs)与生物可降解高分子药物洗脱支架(BP-DES)在DM患者或非DM患者中的有效性和安全性。

方法:共计考察中心2013 年7666例仅植入G2-DES或BP-DES的连续患者。主要有效性终点为靶病变血运重建(TLR),主要安全性终点为2年随访期间死亡或心梗(MI)的复合。

结果:在DM患者中,与BP-DESs相比,G2-DESs的死亡、非致命性MI、TLR、卒中和支架栓塞的发生率相似(均P>0.05)。在非DM患者中,G2-DESs的TVR 和TLR发病率低于BP-DESs(分别为3.2% vs 5.1%,P=0.002;2.2% vs 4.5%,P<0.001)。Kaplan-Meier分析也显示,非DM患者中,G2-DESs的无TVR和TLR生存率好于BP-DESs。多变量分析显示,BP-DES是非DM 患者TLR一个独立风险因素(风险比1.963,95%置信区间1.390~2.772,P<0.001),不能预测重大血管事件的其他部分(P>0.05)。

结论:在非DM患者中,与BP-DESs 相比,G2-DESs的疗效更佳,以TLR风险降低,安全性相似为代表。在对DM 患者的2年随访中,与BP-DESs相比,G2-DESs的有效性和安全性相似。

原始出处:

Tang XF, Ma YL, Song Y, et.al. Biodegradable polymer drug-eluting stents versus second-generation drug-eluting stents in patients with and without diabetes mellitus: a single-center study. Cardiovasc Diabetol. 2018 Aug 14;17(1):114. doi: 10.1186/s12933-018-0758-0.

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    2019-07-02 quxin068
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    2018-10-29 清风拂面

    谢谢分享学习

    0

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    2018-09-09 fusion
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    2018-09-09 医者仁心
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    2018-09-08 liumin1987

    嗯嗯,学习了。

    0

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