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ACC:GIPS-IV:硫代硫酸钠不会减少心肌梗死后的心脏损伤

2022-04-06 MedSci原创 MedSci原创

硫代硫酸钠虽然在首次出现STEMI的患者再灌注时可以安全使用,但对减少梗塞面积没有益处。

4月4日,ACC.22大会上有讲者分享了一项GIPS-IV试验结果:硫代硫酸钠虽然在首次出现STEMI(ST段抬高心肌梗死)的患者再灌注时可以安全使用,但对减少心肌梗塞面积没有任何益处。这是首个硫代硫酸钠治疗心肌梗塞(MI)的临床试验。

该研究共招募2018年至2021年间,在荷兰三个医疗中心首次接受MI治疗的380名受试者。受访者被随机分为两者,一组接受两剂硫代硫酸钠治疗(静脉注射)两剂次间隔6小时,另一组接受两剂安慰剂治疗。

经随访4个月后,该试验没有达到主要研究终点:心肌梗塞面积变化;次要研究终点也没有显著性差异,包括左心室射血分数、 NT-proBNP水平以及肌酸激酶-MB峰值。

该研究的主要负责人Marie-Sophie de Koning表示,“尽管这项研究没有看到硫代硫酸钠对梗死面积或任何次要终点的影响,但这并不能排除硫代硫酸钠可能对心脏病治疗水平低于荷兰的地区产生影响。未来将探索不同的硫化氢供体或给药策略对研究终点是否产生影响,现在判断硫化氢物是否对缺血再灌注损伤不起作用还为时尚早。”

不过,研究人员还观察到,在硫代硫酸钠组中,给药期间受试者恶心呕吐的发生率较高(心血管不良事件发生率低,安全性还是有保证的),再加之该药气味比较强烈,今后进行其它基于硫化氢的临床试验可能比较有挑战性。

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    2022-04-08 chengjn
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    2022-04-06 ms6000001975869717

    学习知识

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