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Diabetologia:利伐沙班 vs 阿司匹林可改善有高心血管风险的2型糖尿病患者的内皮功能,但会增加出血风险

2021-09-09 Nebula MedSci原创

与阿司匹林相比,利伐沙班可改善有亚临床炎症的 2 型糖尿病个体的内皮细胞功能,但也会增加出血风险。

有亚临床炎症的 2 型糖尿病患者存在凝血、活化血小板和内皮功能障碍。近期关于 Xa 因子抑制剂利伐沙班联合低剂量阿司匹林的研究表明,该联合方案可显著降低主要血管事件,特别是在已确诊心血管疾病的 2 型糖尿病患者中。

本研究旨在探索利伐沙班治疗是否会影响内皮功能、动脉僵硬度和血小板活化。

这是一项多中心、前瞻性、随机的、开放性试验,纳入了 179 位有亚临床炎症(高敏性 C 反应蛋白 2-10 mg/l)的、至少有两项代谢综合征特征的 2 型糖尿病患者(病程 2-20 年),对比了直接 Xa 因子抑制剂利伐沙班(5 mg,2/日)vs 阿司匹林(100 mg/日)对内皮功能、皮肤血流、动脉僵硬度和内皮功能及炎症的血清生物标志物的影响。此外,研究人员还评估了血小板中血管扩张剂刺激的磷蛋白 (VASP) 的磷酸化、血小板衍生微粒(PMP)的浓度和分离的 PMP 在体外对 HUVEC 增殖的作用。

研究流程

与阿司匹林相比,利伐沙班持续治疗 20 周(n=89)可显著改善缺血前臂的血流量(3.6±4.7 vs 1.0±5.2 ml/100 ml, p?=?0.004),增加皮肤血流量和降低可溶性 P-选择素血浆水平。

两组缺血后的前臂血流量(FBF)变化

两种药物治疗对动脉僵硬度和生物标志物的影响无明显差异。利伐沙班和阿司匹林都不影响血小板的 VASP 磷酸化。利伐沙班和阿司匹林治疗都可显著增加 PMP 的数量(利伐沙班:365.2±372.1 vs 237.4±157.1 /μl, p=0.005;阿司匹林:266.0±212.7 vs 201.7±162.7 /μl, p=0.021)。

两种药物治疗对多种因子的影响

与阿司匹林组相比,利伐沙班组受试者来源的 PMP 在体外可刺激 HUVEC 增殖。最后,利伐沙班治疗的受试者的出血事件多于阿司匹林治疗的受试者。

综上,该研究结果表明,与阿司匹林相比,Xa 因子抑制剂利伐沙班可改善有亚临床炎症的 2 型糖尿病个体的内皮细胞功能,但也会增加出血风险。

原始出处:

Pistrosch, F., Matschke, J.B., Schipp, D. et al. Rivaroxaban compared with low-dose aspirin in individuals with type 2 diabetes and high cardiovascular risk: a randomised trial to assess effects on endothelial function, platelet activation and vascular biomarkers. Diabetologia (2021). https://doi.org/10.1007/s00125-021-05562-9

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  7. 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time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016237, encodeId=79a3101623e44, content=么啦头绪死咯天空软件卡啊服, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Fri Sep 10 07:01:45 CST 2021, time=2021-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016231, encodeId=5adb101623162, content=阿司匹林对糖代谢尿酸代谢有影响,预防血栓利伐沙班优于阿司匹林但价格较高, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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  8. 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    2021-09-10 查查佳佳

    么啦头绪死咯天空软件卡啊服

    0

  9. 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time=2021-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016237, encodeId=79a3101623e44, content=么啦头绪死咯天空软件卡啊服, beContent=null, objectType=article, channel=null, level=null, likeNumber=124, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIrrxxDxnLic8t6EAs38Qfwo6H2h6JMleIgb9OSYf6LMnVDkQEqUXWoSDWboibjhOBI9SJDTXweqQIA/132, createdBy=50aa5321359, createdName=查查佳佳, createdTime=Fri Sep 10 07:01:45 CST 2021, time=2021-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1016231, encodeId=5adb101623162, content=阿司匹林对糖代谢尿酸代谢有影响,预防血栓利伐沙班优于阿司匹林但价格较高, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210602/57704ea8a151451b828f902d366b1e56/adf031885d6d48638ce70c34c2a853f8.jpg, createdBy=2f245512040, createdName=zfu_med, createdTime=Fri Sep 10 06:53:08 CST 2021, time=2021-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043785, encodeId=15f31043e85cc, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=163, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Fri Sep 10 01:50:17 CST 2021, time=2021-09-10, status=1, ipAttribution=)]
    2021-09-10 zfu_med

    阿司匹林对糖代谢尿酸代谢有影响,预防血栓利伐沙班优于阿司匹林但价格较高

    0

  10. 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    2021-09-10 misszhang

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