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CURR BIOL:睡眠如何巩固记忆

2018-03-11 海北 MedSci原创

你知道短暂的遭遇是如何转化为持久的记忆的吗?先前的研究已经确立了非快速眼动(NREM)睡眠对记忆巩固的作用,以及其慢振荡(SOS)和纺锤波的电生理特征。

你知道短暂的遭遇是如何转化为持久的记忆的吗?先前的研究已经确立了非快速眼动(NREM)睡眠对记忆巩固的作用,以及其慢振荡(SOS)和纺锤波的电生理特征。在相关工作中,实验已经证明NREM睡眠能够提供一个机会窗口,通过提供听觉线索来选择性地增强特定的记忆痕迹,这是一种称为目标记忆再激活(TMR)的过程。

但是,目前仍不清楚的是,TMR是否触发了大脑的内在巩固机制(与SO和/或纺锤波相关),以及这些机制是否会参与有效的记忆信息处理。

为此,来自约克大学的研究人员设计了一种新的范式,其在学习后的小睡期间选择性地建立联想记忆(形容词-对象和形容词-场景对),这能够成功地稳定下一天的记忆。

首先,研究人员发现,与新颖的对照形容词相比,记忆线索引起快速纺锤波的增加。重要的是,在提示引起的纺锤波活动的时间窗期间,与语言提示(对象或场景)相关的记忆类别可以被可靠地解码,该解码的保真度预测TMR的行为整合益处。

这些结果为睡眠纺锤波参与记忆巩固提供了相关的证据。


原始出处:

Scott A. Cairney et al. Memory Consolidation Is Linked to Spindle-Mediated Information Processing during SleepCurrent Biology, 2018; DOI: 10.1016/j.cub.2018.01.087


本文系梅斯医学(MedSci)原创编译整理,转载需授权



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    2018-04-18 sunylz
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    2018-03-18 虈亣靌

    优质资源.共同学习

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM6DGOvNrRdcib3UmzMgpEQplCaQGBmjHytXQqvsuocO2uV2lOAaJibzDafJudKToVfU12LzwArHDb4TSrmU2hk5Qxzc6icoicBK3Dg/0, createdBy=a7901968505, createdName=明心见性, createdTime=Mon Mar 12 10:22:30 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295491, encodeId=86142954915c, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=186, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzR8ylhYfiaoAUx2BsaYHVia1IKhG3Cg8CT84rBrn6iaVRkyAibJxBcLEXabOQ5p19vWgDe34ib5ErxNgx/0, createdBy=8a701629084, createdName=jihuaijun1112, createdTime=Mon Mar 12 10:15:42 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295490, encodeId=8e7929549076, content=学习学习学习, beContent=null, objectType=article, channel=null, level=null, 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objectType=article, channel=null, level=null, likeNumber=144, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTI06MUzr7AI0nTlsgpDTRvVB51yAMdGfTKe8roX48ibEeqHD1dz3UibUa9SibU24UPLcEozJiaSB67WvQ/132, createdBy=fca0106828, createdName=Ramsey, createdTime=Mon Mar 12 09:42:28 CST 2018, time=2018-03-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=295193, encodeId=d27a29519384, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=139, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sun Mar 11 13:39:54 CST 2018, time=2018-03-11, status=1, ipAttribution=), 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    2018-03-12 明心见性

    学习了.谢谢分享!

    0

  5. 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    2018-03-12 jihuaijun1112

    学习学习学习

    0

  6. 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    2018-03-12 jihuaijun1112

    学习学习学习

    0

  7. 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    2018-03-12 1070030296

    受益匪浅

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    2018-03-12 Ramsey

    学习了

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    2018-03-11 131****1460

    学习了受益匪浅

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    2018-03-11 王秀

    学习了.涨知识了!

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