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Clin Cancer Res: 醋酸阿比特龙治疗的前列腺癌患者中游离DNA修饰动态研究

2018-04-11 AlexYang MedSci原创

对醋酸阿比特龙(AA)的原发性抗性能够在20%-40%的患者中发生,醋酸阿比特龙是治疗转移性去势难治性前列腺癌的关键的治疗药物。最近,有研究人员鉴定了能够对AA治疗响应进行预测的生物标记和阐释了治疗抗性相关的机制。研究人员对来自33名AA治疗患者的108份血浆样本进行了游离循环DNA(cfDNA)修饰情况分析。研究发现,在AA敏感和AA抗性患者相比中,有30个胞嘧啶表现出了显著的修饰差异(FDR

对醋酸阿比特龙(AA)的原发性抗性能够在20%-40%的患者中发生,醋酸阿比特龙是治疗转移性去势难治性前列腺癌的关键的治疗药物。最近,有研究人员鉴定了能够对AA治疗响应进行预测的生物标记和阐释了治疗抗性相关的机制。

研究人员对来自33名AA治疗患者的108份血浆样本进行了游离循环DNA(cfDNA)修饰情况分析。研究发现,在AA敏感和AA抗性患者相比中,有30个胞嘧啶表现出了显著的修饰差异(FDR q<0.05),其中的21个胞嘧啶修饰在治疗之前就已经存在差异化修饰。另外,AA敏感患者而不是AA抗性患者,在开始AA治疗后不久就丢失了cfDNA修饰的个体差异,但是这样的变化在治疗后期重新恢复到了起始水平。

最后,研究人员指出,他们的研究对AA治疗响应的预测提供了一系列的潜在生物标记,强调了使用胞嘧啶修饰变异作为生物标记的诊断价值,同时也为AA敏感患者前列腺癌复发的机制提供了一些新的见解。

原始出处:

Gordevicius J, Krisciūnas A, Groot DE et al. Cell-free DNA modification dynamics in abiraterone acetate-treated prostate cancer patients. Clin Cancer Res. 3 April 2018.

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    2018-04-13 zhangyxzsh
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    2018-04-13 LSJ116
  4. [GetPortalCommentsPageByObjectIdResponse(id=1368428, encodeId=4bc6136842864, content=<a href='/topic/show?id=b6f29563625' target=_blank style='color:#2F92EE;'>#醋酸阿比特龙#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95636, encryptionId=b6f29563625, topicName=醋酸阿比特龙)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=362b271, createdName=zexyw01, createdTime=Fri Apr 13 10:56:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569310, encodeId=363e15693105b, content=<a href='/topic/show?id=1c562e42646' target=_blank style='color:#2F92EE;'>#修饰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27426, encryptionId=1c562e42646, topicName=修饰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=29c615505859, createdName=zhangyxzsh, createdTime=Fri Apr 13 10:56:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573571, encodeId=f4ed15e3571c3, content=<a href='/topic/show?id=ad6066363fb' target=_blank style='color:#2F92EE;'>#游离DNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66363, encryptionId=ad6066363fb, topicName=游离DNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d04c15907611, createdName=LSJ116, createdTime=Fri Apr 13 10:56:00 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305107, encodeId=85f530510e0b, content=不错.学习了.谢谢分享.转发, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/11/17/cfa76f1048392033b44c71e9bcb628d9.jpg, createdBy=096c2156900, createdName=梦想起航ing, createdTime=Thu Apr 12 14:07:23 CST 2018, time=2018-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=304882, encodeId=d08030488234, content=对醋酸阿比特龙(AA)的原发性抗性能够在20%-40%的患者中发生.醋酸阿比特龙是治疗转移性去势难治性前列腺癌的关键的治疗药物.最近.有研究人员鉴定了能够对AA治疗响应进行预测的生物标记和阐释了治疗抗性相关的机制., beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Apr 11 21:54:13 CST 2018, time=2018-04-11, status=1, ipAttribution=)]
    2018-04-12 梦想起航ing

    不错.学习了.谢谢分享.转发

    0

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    2018-04-11 有备才能无患

    对醋酸阿比特龙(AA)的原发性抗性能够在20%-40%的患者中发生.醋酸阿比特龙是治疗转移性去势难治性前列腺癌的关键的治疗药物.最近.有研究人员鉴定了能够对AA治疗响应进行预测的生物标记和阐释了治疗抗性相关的机制.

    0

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2018年4月,美国国家综合癌症网络(NCCN)发布了前列腺癌早期检测指南2018年第2版,指南主要内容包括 指南更新摘要 简介 基线评估,风险评估和早期检测评估 活组织检查适应症 活组织检查结果的管理

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