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Cell Death Differ:IL-24缺失抑制IL-4诱导的巨噬细胞M2型转化以预防肺纤维化作用

2020-11-14 xiaozeng MedSci原创

特发性肺纤维化(IPF)作为全球范围内的一种严重的健康问题,特发性间质性肺炎的最常见类型,预后较差。尽管IPF的发病率仅为每年2.8–18例/10万,但确诊后患者的平均生存期仅为2-4年。

特发性肺纤维化(IPF)作为全球范围内的一种严重的健康问题,特发性间质性肺炎的最常见类型,预后较差。尽管IPF的发病率仅为每年2.8–18例/10万,但确诊后患者的平均生存期仅为2-4年。然而IPF发生发展的分子机制仍是未知之数。

在该研究中,研究人员发现,在IPF患者的血清和博莱霉素(bleomycin,BLM)诱导的肺纤维化小鼠模型的支气管肺泡灌洗液(BALF)中均检测到IL-24(IL-20亚家族细胞因子成员)表达水平的升高。而缺失IL-24可以保护小鼠免受BLM诱导的肺损伤和纤维化作用。

IPF患者及BLM诱导小鼠模型中IL-24的表达分析

进一步的研究显示,IL-24缺失能够显著减少BLM诱导的小鼠肺中TGF-β1的产生,并减少M2型巨噬细胞的浸润。机制研究显示,单独的IL-24并不会对巨噬细胞向M2型转化产生明显的影响,而其与IL-4的协同作用则能够促进巨噬细胞的M2型转化作用。

IL-24缺失可减轻肺损伤和肺纤维化

研究人员发现,IL-24能够抑制IL-4诱导的细胞因子信号抑制因子SOCS1和SOCS3的表达水平,并增强了STAT6/PPARγ信号转导通路,最终促进IL-4诱导的M2型巨噬细胞的产生。


总而言之,该研究结果揭示了IL-24与IL-4的协同作用能够促进巨噬细胞向M2型转化,最终促进肺纤维化的发生发展。


原始出处:

Rao, L., Wang, Y., Zhang, L. et al. IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages. Cell Death Differ (03 November 2020).

 

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    2021-03-06 维他命
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    2020-11-16 Nebula-Qin

    IL-24与IL-4的协同作用能够促进巨噬细胞向M2型转化,最终促进肺纤维化的发生发展

    0

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    2020-11-15 cy0328
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    2020-11-15 tomyang93
  7. [GetPortalCommentsPageByObjectIdResponse(id=1784230, encodeId=6a421e84230ac, content=<a href='/topic/show?id=f01159527d' target=_blank style='color:#2F92EE;'>#Differ#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5952, encryptionId=f01159527d, topicName=Differ)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d784426, createdName=isabellayj, createdTime=Sat Jun 19 09:08:00 CST 2021, time=2021-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1872053, encodeId=1e8518e205329, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Thu Aug 05 18:08:00 CST 2021, time=2021-08-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1962355, encodeId=12a7196235545, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Sat Mar 06 15:08:00 CST 2021, time=2021-03-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899537, encodeId=869889953e10, content=IL-24与IL-4的协同作用能够促进巨噬细胞向M2型转化,最终促进肺纤维化的发生发展, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210725/69b5882b3c3845c19efa131b4ff8b1f7/06ccd8f1857e4e14862049ab235618eb.jpg, createdBy=74c72110107, createdName=Nebula-Qin, createdTime=Mon Nov 16 09:52:19 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531691, encodeId=3093153169125, content=<a href='/topic/show?id=770e5e9457' target=_blank style='color:#2F92EE;'>#Death#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5794, encryptionId=770e5e9457, topicName=Death)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32e312278742, createdName=cy0328, createdTime=Sun Nov 15 16:08:00 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1626071, encodeId=e33e16260e1b8, content=<a href='/topic/show?id=87369652f3' target=_blank style='color:#2F92EE;'>#IL-2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9652, encryptionId=87369652f3, topicName=IL-2)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ea8220955712, createdName=tomyang93, createdTime=Sun Nov 15 16:08:00 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899061, encodeId=fb6f899061cb, content=已读, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q3auHgzwzM6tia9pyZiaPziaeLHadUZP17uiav8DTro6peFy5lvuO5EjYrG4ButKWVynGX1CUFFBbXhib9bjE77pkHw/132, createdBy=41785253089, createdName=医路前行4231, createdTime=Sat Nov 14 08:50:03 CST 2020, time=2020-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899049, encodeId=47d389904919, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=131, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a935426501, createdName=ms3000000924731757, createdTime=Sat Nov 14 07:52:39 CST 2020, time=2020-11-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899043, encodeId=c0e6899043c3, content=学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201112/48ce10dbe4f44dff836cf6a9bfc5f863/5ee97f929dcb42b4a17a5f468f3deb16.jpg, createdBy=43385434334, createdName=Sylvia·Sum, createdTime=Sat Nov 14 05:32:05 CST 2020, time=2020-11-14, status=1, ipAttribution=)]
    2020-11-14 医路前行4231

    已读

    0

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    2020-11-14 ms3000000924731757

    学习了

    0

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    2020-11-14 Sylvia·Sum

    学习学习

    0

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