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Biomed Res Int:高蛋白饮食和益生菌干酪乳杆菌可减小AFB1的影响

2018-07-02 MedSci MedSci原创

益生菌干酪乳杆菌Shirota(LcS)是一种潜在的黄曲霉毒素B1(AFB1)清除剂。然而,很少有研究调查饮食,特别是高蛋白(HP)饮食对益生菌结合AFB1的影响。本研究旨在确定HP饮食对LcS结合AFB1并减少AFB1诱导的大鼠中黄曲霉毒素M1(AFM1)能力的影响。将Sprague Dawley大鼠随机分成三组:A(仅HP),B(HP + 108CFU LcS +25μgAFB1/kg BW)

益生菌干酪乳杆菌Shirota(LcS)是一种潜在的黄曲霉毒素B1(AFB1)清除剂。然而,很少有研究调查饮食,特别是高蛋白(HP)饮食对益生菌结合AFB1的影响。本研究旨在确定HP饮食对LcS结合AFB1并减少AFB1诱导的大鼠中黄曲霉毒素M1(AFM1)能力的影响。

将Sprague Dawley大鼠随机分成三组:A(仅HP),B(HP + 108CFU LcS +25μgAFB1/kg BW)和C(HP +25μgAFB1/kg BW)。所有组的AST和ALP水平均较高,但其他肝功能的生物标志物处于正常范围,肝脏的组织学显示无结构改变。B组大鼠尿素水平(10.02±0.73mmol/l)明显低于A组(10.82±0.26mmol/l),差异有统计学意义(P <0.05)。C组小鼠结肠癌的发生率明显高于B组,且B组大鼠的AFM1浓度(0.39±0.01 ng/ml)明显低于C组(P <0.05) (5.22±0.28ng/ml)。

综上所述,该研究结果表明,通过这些发现,HP饮食补充LcS通过阻止AFB1在小肠中吸收并减少尿AFM1减轻了AFB1的副作用。

原始出处:

Nurul Adilah Z, Liew WP, et al., Effect of High Protein Diet and Probiotic Lactobacillus casei Shirota Supplementation in Aflatoxin B1-Induced Rats. Biomed Res Int. 2018 May 23;2018:9568351. doi: 10.1155/2018/9568351. eCollection 2018.

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    2018-12-21 sunylz
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    2018-07-04 海豹
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    2018-07-02 1e0f8808m18(暂无匿称)

    益生菌.高蛋白饮食减少AFB1的对人影响.

    0

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