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2019ASCO:阿斯利康的PARP抑制剂Lynparza,在胰腺癌III期临床中表现出色

2019-06-03 不详 MedSci原创

阿斯利康(AstraZeneca)和默克公司(Merck)在芝加哥举行的ASCO大会上发布了他们的PARP抑制剂Lynparza在胰腺癌中的新数据。

阿斯利康(AstraZeneca)和默克公司(Merck)在芝加哥举行的ASCO大会上发布了他们的PARP抑制剂Lynparza在胰腺癌中的新数据。

在携带BRCA突变晚期胰腺癌患者中进行的第3阶段POLO试验发现,Lynparza作用后患者的无进展生存期为7.4个月,几乎是安慰剂组3.8个月的两倍。

大约5%至6%的胰腺癌是由一种或两种BRCA基因突变引起的,这些基因通常与卵巢癌乳腺癌相关,但在很多肿瘤中都能观察到。

AZ的肿瘤学研发负责人JoséBaselga表示,该公司将"尽快"向监管机构提交结果,可能为Lynparza在卵巢癌和乳腺癌之外,开辟第三个适应症。

原始出处:


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    2019-08-22 quxin068
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    2019-08-01 jklm09
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    2019-10-03 juliusluan78
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    2019-06-05 lishiwen

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