Baidu
map

Life Sci:反复接触七氟醚会损害老年雄性大鼠的学习能力和记忆

2017-12-11 李华宇 “罂粟花”微信号

危重病患者常需要反复手术干预,因此探讨反复接触麻醉药物对学习和记忆的影响就显得非常重要。七氟醚是一种广泛使用的吸入麻醉剂,对神经系统几乎没有副作用,并能使意识迅速恢复。但七氟醚暴露的长期影响和重复七氟醚暴露后对认知功能的影响却少有文献报道,这与现有的研究相矛盾。

背景与目的:危重病患者常需要反复手术干预,因此探讨反复接触麻醉药物对学习和记忆的影响就显得非常重要。七氟醚是一种广泛使用的吸入麻醉剂,对神经系统几乎没有副作用,并能使意识迅速恢复。但七氟醚暴露的长期影响和重复七氟醚暴露后对认知功能的影响却少有文献报道,这与现有的研究相矛盾。

方法:在本研究中,Morris水迷宫试验被用来研究单次(4小时)或重复(每天2小时连续5天)暴露于1.5%或2.5%七氟醚后对老年(16-18月龄)雄性大鼠学习能力和记忆的长期影响。测试是从最后一次暴露后1天到4周内进行。在海马中,通过对脑源性神经营养因子(BDNF),NF-κBmRNA和细胞凋亡率进行检验,以确定在单次或重复接触七氟醚后对认知功能和记忆的影响是否与细胞生化的改变有关。

结果:反复接触2.5%七氟醚降低了老年雄性大鼠海马的BDNF蛋白水平,提高了海马的NF-κBmRNA水平,增加了锥体细胞凋亡率。单次暴露于2.5%七氟醚以及反复接触1.5%或2.5%七氟醚显着损害了老年雄性大鼠的学习能力和记忆。

结论:反复接触七氟醚会损害老年雄性大鼠的学习能力和记忆,这种损伤伴随着海马内与认知功能相关的生化改变。

原始出处:

Guo S,et al.,Repeated exposure to sevoflurane impairs the learning and memory of older male rats.Life Sci. 2017 Nov 16. pii: S0024-3205(17)30602-1.

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2068542, encodeId=ad5020685422e, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Tue Jul 31 10:35:00 CST 2018, time=2018-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412676, encodeId=00bf14126e673, content=<a href='/topic/show?id=1c2f195092d' target=_blank style='color:#2F92EE;'>#七氟醚#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19509, encryptionId=1c2f195092d, topicName=七氟醚)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a102881238, createdName=linagood, createdTime=Wed Dec 13 10:35:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629432, encodeId=8741162943222, content=<a href='/topic/show?id=a4a84548ea9' target=_blank style='color:#2F92EE;'>#学习能力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45487, encryptionId=a4a84548ea9, topicName=学习能力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ef421335630, createdName=wolongzxh, createdTime=Wed Dec 13 10:35:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268681, encodeId=c50d2686812a, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Dec 11 19:52:28 CST 2017, time=2017-12-11, status=1, ipAttribution=)]
    2018-07-31 clmlylxy
  2. [GetPortalCommentsPageByObjectIdResponse(id=2068542, encodeId=ad5020685422e, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Tue Jul 31 10:35:00 CST 2018, time=2018-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412676, encodeId=00bf14126e673, content=<a href='/topic/show?id=1c2f195092d' target=_blank style='color:#2F92EE;'>#七氟醚#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19509, encryptionId=1c2f195092d, topicName=七氟醚)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a102881238, createdName=linagood, createdTime=Wed Dec 13 10:35:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629432, encodeId=8741162943222, content=<a href='/topic/show?id=a4a84548ea9' target=_blank style='color:#2F92EE;'>#学习能力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45487, encryptionId=a4a84548ea9, topicName=学习能力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ef421335630, createdName=wolongzxh, createdTime=Wed Dec 13 10:35:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268681, encodeId=c50d2686812a, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Dec 11 19:52:28 CST 2017, time=2017-12-11, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=2068542, encodeId=ad5020685422e, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Tue Jul 31 10:35:00 CST 2018, time=2018-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412676, encodeId=00bf14126e673, content=<a href='/topic/show?id=1c2f195092d' target=_blank style='color:#2F92EE;'>#七氟醚#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19509, encryptionId=1c2f195092d, topicName=七氟醚)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a102881238, createdName=linagood, createdTime=Wed Dec 13 10:35:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629432, encodeId=8741162943222, content=<a href='/topic/show?id=a4a84548ea9' target=_blank style='color:#2F92EE;'>#学习能力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45487, encryptionId=a4a84548ea9, topicName=学习能力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ef421335630, createdName=wolongzxh, createdTime=Wed Dec 13 10:35:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268681, encodeId=c50d2686812a, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Dec 11 19:52:28 CST 2017, time=2017-12-11, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2068542, encodeId=ad5020685422e, content=<a href='/topic/show?id=59371088215' target=_blank style='color:#2F92EE;'>#Life#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10882, encryptionId=59371088215, topicName=Life)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fc8528, createdName=clmlylxy, createdTime=Tue Jul 31 10:35:00 CST 2018, time=2018-07-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1412676, encodeId=00bf14126e673, content=<a href='/topic/show?id=1c2f195092d' target=_blank style='color:#2F92EE;'>#七氟醚#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=19509, encryptionId=1c2f195092d, topicName=七氟醚)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0a102881238, createdName=linagood, createdTime=Wed Dec 13 10:35:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629432, encodeId=8741162943222, content=<a href='/topic/show?id=a4a84548ea9' target=_blank style='color:#2F92EE;'>#学习能力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45487, encryptionId=a4a84548ea9, topicName=学习能力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ef421335630, createdName=wolongzxh, createdTime=Wed Dec 13 10:35:00 CST 2017, time=2017-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268681, encodeId=c50d2686812a, content=了解一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Mon Dec 11 19:52:28 CST 2017, time=2017-12-11, status=1, ipAttribution=)]
    2017-12-11 wxl882001

    了解一下

    0

相关资讯

Mol Med Rep:新生小鼠反复吸入七氟醚抑制浦肯野细胞的信息传递并且通过GABAA受体的ε(艾普西龙)亚基减缓运动神经发育

尽管全身麻醉对小脑信息传递和运动功能的影响尚不清楚,但是全身麻醉还是广泛应用于小儿外科手术。

PLoS One:七氟醚显著延长高血糖患者的QTc间期

QTc间期延长是糖尿病患者的一种严重并发症并增加其死亡率。高血糖抑制延迟整流钾通道电流的快速成分(Ikr)而引起心电图QTc间期的延长。同时七氟醚抑制Ikr 引起QTc间期延长。事实上,尖端扭转型室速也发生在七氟醚麻醉期间糖尿病控制不佳的患者身上。

Lancet Child Adol Health:可乐定预防儿童七氟醚麻醉后的术后躁动

研究认为,可乐定可安全地用于预防男孩七氟醚麻醉后的术后躁动

Anesth Analg:较之异氟醚,七氟醚可很大程度减轻大鼠肺源性急性呼吸窘迫综合征引起的肺损伤

挥发性麻醉药能调节急性呼吸窘迫综合征(ARDS)中的炎症反应。而它们是否因为ARDS病因的不同而呈现出不同作用,目前尚不十分清楚。我们假设体内、体外实验中,七氟醚和异氟醚在肺源性(p)和非肺源性(exp)ARDS对肺损伤的影响中不存在差异。

Baidu
map
Baidu
map
Baidu
map