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Clinica Chimica Acta：疑似家族性高胆固醇血症患者的冠状动脉疾病和风险相关LPA变异？

2020-08-09 MedSci原创 MedSci原创

家族性高胆固醇血症患者高胆固醇血症患者
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研究表明LPA中rs3798220和rs10455872单核苷酸多态性(SNPs)与血浆脂蛋白(a) [Lp(a)]浓度升高和冠状动脉疾病(CAD)相关。

研究表明LPA中rs3798220和rs10455872单核苷酸多态性(SNPs)与血浆脂蛋白(a) [Lp(a)]浓度升高和冠状动脉疾病(CAD)相关。研究人员调查了763例疑似家族性高胆固醇血症(FH)患者rs3798220和rs10455872与流行的CAD之间的关系。利用SEQUENOM平台检测LPA中rs3798220和rs10455872的SNP。

两组LPA SNPs均与冠心病显著相关，但校正其他危险因素后仅与rs3798220相关(优势比[OR] 2.05;95%置信区间[CI] 1.02-4.12;p = 0.045)，在校正Lp(a)浓度后均无变化。两个SNP均与Lp(a)增加呈正相关且独立相关(rs3798220: OR 1.27;95%可信区间0.96 - -1.57;p < 0.001。rs10455872: 1.41;95%可信区间1.24 - -1.58;p < 0.001)。Lp(a)的血浆浓度与流行的CAD独立相关(或1.28;(95% CI 1.08-1.52, p = 0.005)，校正LPA SNPs和其他心血管危险因素后，虽然rs3798220和rs10455872 snp均与疑似FH患者中Lp(a)浓度和普遍的CAD相关，但这并非独立于Lp(a)浓度。

研究结果表明，量化Lp(a)比评估这些Lp(a)相关SNP更有可能用于增强CAD风险预测。

原始出处：

Michael M. Page，Katrina L. Ellis，Coronary artery disease and the risk-associated LPA variants, rs3798220 and rs10455872, in patients with suspected familial hypercholesterolaemia

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    2021-03-31 windight

    #CTA#

    0

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    2020-08-11 howi

    #冠状动脉疾病#

    0

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    2020-08-11 12498dabm77暂无昵称

    #变异#

    0

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    2020-08-11 刘阔

    #高胆固醇血症#

    0

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    2020-08-11 ms9474365431325850

    #LPA#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1850020, encodeId=3648185002089, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Mar 31 18:50:56 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252944, encodeId=f46312529441d, content=<a href='/topic/show?id=463230886b8' target=_blank style='color:#2F92EE;'>#冠状动脉疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30886, encryptionId=463230886b8, topicName=冠状动脉疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Aug 11 13:50:56 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342723, encodeId=84381342e23a2, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Tue Aug 11 13:50:56 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380102, encodeId=379f138010209, content=<a href='/topic/show?id=bef6102602a9' target=_blank style='color:#2F92EE;'>#高胆固醇血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102602, encryptionId=bef6102602a9, topicName=高胆固醇血症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1d1470, createdName=刘阔, createdTime=Tue Aug 11 13:50:56 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581418, encodeId=44da15814185c, content=<a href='/topic/show?id=c0c9110333d' target=_blank style='color:#2F92EE;'>#LPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11033, encryptionId=c0c9110333d, topicName=LPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a7b16794085, createdName=ms9474365431325850, createdTime=Tue Aug 11 13:50:56 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629577, encodeId=784816295e784, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26fc21339997, createdName=wetgdt, createdTime=Tue Aug 11 13:50:56 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807166, encodeId=5cb580e166b4, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Mon Aug 10 00:41:51 CST 2020, time=2020-08-10, status=1, ipAttribution=)]
    2020-08-11 wetgdt

    #家族性#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1850020, encodeId=3648185002089, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Wed Mar 31 18:50:56 CST 2021, time=2021-03-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252944, encodeId=f46312529441d, content=<a href='/topic/show?id=463230886b8' target=_blank style='color:#2F92EE;'>#冠状动脉疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30886, encryptionId=463230886b8, topicName=冠状动脉疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Tue Aug 11 13:50:56 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1342723, encodeId=84381342e23a2, content=<a href='/topic/show?id=34cb381023e' target=_blank style='color:#2F92EE;'>#变异#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38102, encryptionId=34cb381023e, topicName=变异)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=78c32500188, createdName=12498dabm77暂无昵称, createdTime=Tue Aug 11 13:50:56 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380102, encodeId=379f138010209, content=<a href='/topic/show?id=bef6102602a9' target=_blank style='color:#2F92EE;'>#高胆固醇血症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102602, encryptionId=bef6102602a9, topicName=高胆固醇血症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d1d1470, createdName=刘阔, createdTime=Tue Aug 11 13:50:56 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581418, encodeId=44da15814185c, content=<a href='/topic/show?id=c0c9110333d' target=_blank style='color:#2F92EE;'>#LPA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11033, encryptionId=c0c9110333d, topicName=LPA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a7b16794085, createdName=ms9474365431325850, createdTime=Tue Aug 11 13:50:56 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1629577, encodeId=784816295e784, content=<a href='/topic/show?id=c61d4641821' target=_blank style='color:#2F92EE;'>#家族性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46418, encryptionId=c61d4641821, topicName=家族性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26fc21339997, createdName=wetgdt, createdTime=Tue Aug 11 13:50:56 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807166, encodeId=5cb580e166b4, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Mon Aug 10 00:41:51 CST 2020, time=2020-08-10, status=1, ipAttribution=)]
    2020-08-10 yangchou

    学习了，谢谢

    0

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