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ECCMID会议:哌拉西林 - 他唑巴坦不推荐用于由大肠杆菌或肺炎链球菌引起的感染

2018-04-25 MedSci MedSci原创

近日,在第28届欧洲临床微生物学和传染病大会(ECCMID)会议上,研究人员指出,由头孢曲松耐药大肠埃希菌和肺炎克雷伯菌引起的患者感染患者用哌拉西林-他唑巴坦治疗与美罗培南治疗相比死亡率显著较高,因此提示在这种情况下应避免使用哌拉西林-他唑巴坦。

近日,在第28届欧洲临床微生物学和传染病大会(ECCMID会议上,研究人员指出,由头孢曲松耐药大肠埃希菌和肺炎克雷伯菌引起的患者感染患者用哌拉西林-他唑巴坦治疗与美罗培南治疗相比死亡率显著较高,因此提示在这种情况下应避免使用哌拉西林-他唑巴坦。

美罗培南被怀疑在推动对碳青霉烯耐药性增加方面发挥重要作用,因此研究人员在积极寻找替代品。研究人员假设哌拉西林-他唑巴坦在治疗血液感染方面并不逊色于美罗培南。20142月至20177月,来自9个国家32个治疗中心的患者在最初血培养采集后72小时内被随机分组,每6小时接受哌拉西林-他唑巴坦(4.5g)治疗或每8小时接受美洛培南(1g)治疗。

使用哌拉西林-他唑巴坦治疗由大肠杆菌或肺炎克雷伯菌引起的血液感染对第三代头孢抗生素不敏感,低于美罗培南,在这种情况下应该避免使用这种疗法。在由大肠杆菌或肺炎链球菌引起的血液感染的378名患者中,23名(12.3%)使用哌拉西林-他唑巴坦治疗的患者在随机分组后30天内死亡,而7名(3.7%)接受美罗培南治疗的患者(P = 0.002)在随机分组后30天内死亡。

原始出处:

http://www.firstwordpharma.com/node/1559435?tsid=4#axzz5DdyMTt4V

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    2018-08-05 仁医06
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    2019-04-06 shalley75
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流感和肺炎是导致老年人相关疾病发生和死亡的重要原因,疫苗接种是其预防的重要手段之一。我国大部分地区流感疫苗及肺炎链球菌疫苗接种率均较低,且公众对疫苗接种的认知尚不足,因此,提高公众对接种疫苗重要性的认识,主动接受疫苗接种十分必要。公众接种疫苗意识的提高,离不开医务人员对相关疾病、疫苗等相关科学知识的普及和健康教育。为了做好医务人员尤其是临床医生规范、系统、科学地普及老年人接种流感疫苗和肺炎链球菌疫

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