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PLos One:心脏手术后发生急性肾损伤与长期死亡率是否有关?

2017-07-13 MedSci MedSci原创

心脏手术中发生的急性肾损伤(AKI)与并发症、早期和晚期死亡率以及医疗支出的增加有关。 目前,AKI对长期随访死亡率的总体动态的影响尚未得到充分调查研究。近期,一项发表在杂志PLos One上的研究纳入了7075例心脏手术的成年患者进行了纵向队列研究。此项研究分别在1年、5年、10年和15年或国家死亡登记处调查获得后续数据。以5个时间间隔评估全因死亡率:I)术后30天至1年;二)1〜3年;三)3〜

心脏手术中发生的急性肾损伤(AKI)与并发症、早期和晚期死亡率以及医疗支出的增加有关。 目前,AKI对长期随访死亡率的总体动态的影响尚未得到充分调查研究。

近期,一项发表在杂志PLos One上的研究纳入了7075例心脏手术的成年患者进行了纵向队列研究。

此项研究分别在1年、5年、10年和15年或国家死亡登记处调查获得后续数据。以5个时间间隔评估全因死亡率:I)术后30天至1年;二)1〜3年;三)3〜5年;IV)5〜10年;和V)10至15年。对于合并症和术前、术中和术后变量的死亡率进行了调整,使用Cox比例风险回归模型在每个时期内进行评估。 

此项研究结果显示:AKI的总发病率为36.1%。AKI是手术后前五年的独立预测因子(30天至1年:HR 1.834,95%CI 1.459至2.306;1至3年:HR 1.285,95%CI 1.023至1.610; 3至五年:HR 1.330,95%CI 1.123至1.750)。只有年龄、糖尿病和CHF与整个随访期间的死亡风险增加相关。

此项研究表明:AKI与长期死亡率有短暂的相关性,但逐渐减少,至术后5年消失。

原始出处:
Ferreiro A, Lombardi R. Acute kidney injury after cardiac surgery is associated with mid-term but not long-term mortality: A cohort-based study. PLoS One. 2017 Jul 10;12(7):e0181158. doi: 10.1371/journal.pone.0181158. eCollection 2017.

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    2017-07-18 海之蓝

    谢谢你哈

    0

  3. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Fri Jul 14 06:48:21 CST 2017, time=2017-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221958, encodeId=f7d02219588c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KiblTyxD95ExbzUoCVcRuhPibXboL28wicFMTXUhCA0RWCyQZYC5Na3ap7CxjialMkB50VEJ0XToQQTC/0, createdBy=470c1945776, createdName=方舒, createdTime=Thu Jul 13 22:04:44 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2017-07-15 三生有幸9135

    学习一下谢谢分享

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4BGdu4COj6QWFqgMd3xnWDdgLZKUGI32veZvO2qFAQvpYr1eMbUOTqMvlZWc3MsugtFMHzxDwial/0, createdBy=88731939304, createdName=圣艮山, createdTime=Sat Jul 15 10:08:05 CST 2017, time=2017-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397253, encodeId=8102139e2538f, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Sat Jul 15 08:27:00 CST 2017, time=2017-07-15, status=1, ipAttribution=), 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Fri Jul 14 06:48:21 CST 2017, time=2017-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221958, encodeId=f7d02219588c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KiblTyxD95ExbzUoCVcRuhPibXboL28wicFMTXUhCA0RWCyQZYC5Na3ap7CxjialMkB50VEJ0XToQQTC/0, createdBy=470c1945776, createdName=方舒, createdTime=Thu Jul 13 22:04:44 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2017-07-15 圣艮山

    学习了不少事情!

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Fri Jul 14 06:48:21 CST 2017, time=2017-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221958, encodeId=f7d02219588c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KiblTyxD95ExbzUoCVcRuhPibXboL28wicFMTXUhCA0RWCyQZYC5Na3ap7CxjialMkB50VEJ0XToQQTC/0, createdBy=470c1945776, createdName=方舒, createdTime=Thu Jul 13 22:04:44 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2017-07-14 三生有幸9135

    学习一下谢谢分享

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=d41c2055892, createdName=184****9840, createdTime=Fri Jul 14 06:48:21 CST 2017, time=2017-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221958, encodeId=f7d02219588c, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KiblTyxD95ExbzUoCVcRuhPibXboL28wicFMTXUhCA0RWCyQZYC5Na3ap7CxjialMkB50VEJ0XToQQTC/0, createdBy=470c1945776, createdName=方舒, createdTime=Thu Jul 13 22:04:44 CST 2017, time=2017-07-13, status=1, ipAttribution=)]
    2017-07-14 ylzr123

    认真学习,把间接经验应用到临床实践中去,然后再总结出新思路。给点赞啦

    0

  8. 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    2017-07-14 1ddf0692m34(暂无匿称)

    学习了,好文章

    0

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    2017-07-14 184****9840

    学习了谢谢分享

    0

  10. 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    2017-07-13 方舒

    学习

    0

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