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Diabetes Care:非糖尿病患者的糖代谢状况和主动脉硬化进展的相关性分析!

2017-01-26 xing.T MedSci原创

由此可见,HbA1c与非糖尿病个体主动脉硬化加速发展相关。这些研究结果表明,长期的糖代谢状况,即使在非糖尿病个体,也可以一个重要的预防血管老化的策略。

主动脉硬化是未来的发病率和死亡率的一个重要的预测指标。糖尿病与主动脉硬化增加有关,而非糖尿病患者的糖代谢状况加速动脉硬化的重要性尚不清楚。近日,糖尿病领域权威杂志Diabetes Care针对这一临床问题发表了一篇研究文章。研究人员旨在验证不良糖代谢状况可以独立于已知的动脉硬化危险因素与非糖尿病患者主动脉加速硬化相关这一假设。

研究人员对4386名参与Whitehall II研究的非糖尿病患者在2008-2009年期间评估了基础的糖代谢状况及其他心血管危险因素,并且随访至2012-2013年期间评估了颈-股动脉脉搏波速度(cfPWV)。

评估基线cfPWV队列的参与者平均年龄为60岁,74%为男性。在4年的随访过程中cfPWV从(平均数±标准误)8.30±0.03增加到了8.98±0.04m/s。在基础水平,cfPWV与空腹、餐后2小时血糖、HbA1c以及HOMA-胰岛素抵抗(HOMA-IR)相关。对生理混杂因素和心血管危险因素进行调整后,HbA1c、HOMA-IR与cfPWV的进展相关。HbA1c和HOMA-IR每增加一个标准差与更大的cfPWV增加相关(分别为每5年0.11m/s,[95%可信区间为0.04-0.18],P=0.003和每5年0.09m/s,[0.01-0.17],P=0.03)。进一步校正BMI可以减弱HOMA-IR与cfPWV的相关性,但不减弱HbA1c与cfPWV的相关性。

由此可见,HbA1c与非糖尿病个体主动脉硬化加速发展相关。这些研究结果表明,长期的糖代谢状况,即使在非糖尿病个体,也可以一个重要的预防血管老化的策略。

原始出处:

Carmel M. McEniery, et al. Nondiabetic Glucometabolic Status and Progression of Aortic Stiffness: The Whitehall II Study. Diabetes Care 2017. 

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  8. 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    2017-01-30 wmu姿

    学习了新知识开心

    0

  9. 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    2017-01-29 ylzr123

    HbA1c与非糖尿病个体主动脉硬化加速发展相关。长期的糖代谢状况,即使在非糖尿病个体,也可以一个重要的预防血管老化的策略。

    0

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    2017-01-28 zz70

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依折麦布争议再起:非糖尿病患者或无获益?

作为一种通过减少肠道内胆固醇吸收的非他汀类降脂药物,依折麦布在今年7月公布的IMPROVE-IT研究中大放异彩:在他汀治疗的基础上,急性冠脉综合征患者应用依折麦布可以更好地改善预后。这一研究也为“降得越低越好”的“LDL假说”提供了强有力的证据支持。 但时隔1个月后,欧洲心脏病学(ESC)年会上公布的IMPROVE-IT亚组研究却表明,依折麦布的获益或仅限于糖尿病患者。 在该研究的亚组

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