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Nat Commun:节制饮食使肠道微生物群更健康

2013-08-05 natureasia natureasia

本期Nature Communications上发表的一篇论文报告说,限制热量促进肠道细菌的生长,同时实验鼠的寿命也会有所延长。这一发现表明,限制热量也许会通过诱导一个健康的肠道微生物群来增强其对宿主的健康促进效应。 通过减少食物摄取限制热量已知能延长一系列模型生物的寿命。肠道微生物群在宿主健康和疾病中所起作用正在越来越多地被认识到,其组成主要由饮食决定。Liping Zhao让小鼠终生采用一种

本期Nature Communications上发表的一篇论文报告说,限制热量促进肠道细菌的生长,同时实验鼠的寿命也会有所延长。这一发现表明,限制热量也许会通过诱导一个健康的肠道微生物群来增强其对宿主的健康促进效应。

通过减少食物摄取限制热量已知能延长一系列模型生物的寿命。肠道微生物群在宿主健康和疾病中所起作用正在越来越多地被认识到,其组成主要由饮食决定。Liping Zhao让小鼠终生采用一种热量受到限制的饮食,并对它们肠道微生物群随时间所发生的结构变化进行记录。

该研究小组报告说,特定细菌,如乳酸杆菌属,与寿命成正相关,其数量因热量限制而增加。同样,这一热量受到限制的饮食减少了与寿命成负相关的细菌的数量。这些变化与血清中“脂多糖结合蛋白”(经常与炎症关联在一起的一个标记物)水平的降低有关,这表明:由来自肠道细菌的抗原所造成的炎症降低,也许是限制热量所带来的健康好处之一。

还需要进一步的研究来弄清肠道微生物群的这些结构变化怎样延长寿命,同时确认它们是否能用作饮食性抗衰老干预措施的开发工作的生物标记。

Zhang C, Li S, Yang L, Huang P, Li W, Wang S, Zhao G, Zhang M, Pang X, Yan Z, Liu Y, Zhao L.Structural modulation of gut microbiota in life-long calorie-restricted mice.Nat Commun. 2013 Jul 16;4:2163. doi: 10.1038/ncomms3163.

PMID:
23860099

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    2014-04-27 liuli5079
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    2013-10-09 liye789132251
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