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Cardiovasc Diabetol:甘油三酯-葡萄糖指数越高,动脉硬化风险越高!

2021-07-20 MedSci原创 MedSci原创

甘油三酯-葡萄糖指数越高,动脉硬化风险越高

据报道,甘油三酯-葡萄糖 (TyG) 指数是胰岛素抵抗的简单替代指标,与动脉硬化有关。但是,既往研究受横断面设计的限制。该研究目的是探究TyG指数与动脉硬化进展之间的纵向关联。

从Kailuan研究中提取了6028位受试者。TyG指数计算为ln(空腹甘油三酯[mg/dL]×空腹血糖[mg/dL]/2)。使用臂踝脉搏波速度(baPWV)测量动脉僵硬度。通过反复测量baPWV的年增长率来评估动脉硬化进展。采用多元线性回归模型估计TyG 指数与baPWV的横断面关联,采用Cox比例风险模型研究TyG指数与动脉硬化风险之间的纵向关联。

甘油三酯-葡萄糖指数与动脉硬化风险的相关性

多元线性回归分析表明,TyG指数每增加一个单位,基线baPWV就会增加39 cm/s(95%CI 29-48 cm/s,p<0.001),baPWV的年增长率就增加0.29%/年(95%CI 0.17-0.42%/年)。在随访的26839个人·年中,共发生了883例动脉硬化病例。TyG指数最高四分位数的受试者的动脉硬化风险较TyG指数最低四分数的受试者高出58%(HR 1.58; 95%CI 1.25-2.01,p<0.001)。此外,受限性三次样条分析显示,TyG指数与动脉硬化风险之间存在显著的剂量反应关系(p=0.005)。

综上所述,TyG指数较高的受试者发生动脉硬化的风险较高。TyG指数较高的受试者应注意下动脉硬化进展的风险,以便即使调整生活方式及进行相应的干预治疗。

原始出处:

Wu, S., Xu, L., Wu, M. et al. Association between triglyceride-glucose index and risk of arterial stiffness: a cohort study. Cardiovasc Diabetol 20, 146 (2021). https://doi.org/10.1186/s12933-021-01342-2

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    2021-11-20 quxin068
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    2021-07-21 ms6000000251792580

    太好了

    0

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