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Diabetes Care:负荷后1h血糖升高示葡萄糖耐受不良(GI)

2012-03-03 MedSci MedSci原创

  意大利学者的一项研究表明,负荷后1小时血糖≥155 mg/dl可能代表了葡萄糖耐量正常(NGT)与2型糖尿病之间的葡萄糖耐受不良(glucose intolerance,GI)中间状态,并且以胰岛素抵抗和β细胞功能降低为特征。论文于2012年2月22日在线发表于《糖尿病护理》(Diabetes Care)杂志。   NGT人群负荷后1小时血糖≥155 mg/dl

  意大利学者的一项研究表明,负荷后1小时血糖≥155 mg/dl可能代表了葡萄糖耐量正常(NGT)与2型糖尿病之间的葡萄糖耐受不良(glucose intolerance,GI)中间状态,并且以胰岛素抵抗和β细胞功能降低为特征。论文于2012年2月22日在线发表于《糖尿病护理》(Diabetes Care)杂志。

  NGT人群负荷后1小时血糖≥155 mg/dl(NGT 1小时较高)的NGT个体出现2型糖尿病风险升高。此项研究共纳入305例无糖尿病的2型糖尿病患者。利用口服葡萄糖耐量试验(OGTT)和静脉葡萄糖耐量试验(IVGTT)衍生指数评估胰岛素释放。利用高胰岛素-正葡萄糖钳夹技术测定胰岛素敏感性。

  结果显示,对年龄、性别和体质指数(BMI)进行校正后,与负荷后1小时血糖<155 mg/dl(NGT 1小时较低)的个体相比,NGT 1小时较高的个体胰岛素敏感性较低。两组受试者在OGTT估算的胰岛素分泌方面无差异。与之相反,对年龄、性别和BMI进行校正后,与 NGT 1小时较低的个体相比,NGT 1小时较高的个体在IVGTT期间急性胰岛素反应和处置指数方面出现显著降低。就OGTT和IVGTT期间总体胰岛素反应比所估算的肠促胰岛素效应而言,NGT 1小时较高者高于NGT 1小时较低者。

  链接:

  Insulin Sensitivity, β-Cell Function, and Incretin Effect in Individuals With Elevated 1-h Postload Plasma Glucose Levels

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