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Int J Oral Sci:TGF-β2下调牙囊干细胞炎症条件下的成骨作用

2018-10-10 MedSci MedSci原创

骨形成对于已经被炎症损伤的区域中的骨相关结构的重建是重要的。炎性病症,如在风湿性关节炎,囊性纤维化和牙周炎,成骨细胞的分化被抑制。本研究的重点是牙囊干细胞(DFSCs),这种细胞在牙胚发育过程中发现并参与牙周病牙槽骨和牙周组织的重建。牙周炎时可观察到骨的破坏。目前,关于炎性环境与骨形成之间的关系知之甚少。 本研究发现,与正常DFSC相比,炎症DFSC的成骨分化导致碱性磷酸酶(ALP)活性和茜

骨形成对于已经被炎症损伤的区域中的骨相关结构的重建是重要的。炎性病症,如在风湿性关节炎,囊性纤维化和牙周炎,成骨细胞的分化被抑制。本研究的重点是牙囊干细胞(DFSCs),这种细胞在牙胚发育过程中发现并参与牙周病牙槽骨和牙周组织的重建。牙周炎时可观察到骨的破坏。目前,关于炎性环境与骨形成之间的关系知之甚少。

本研究发现,与正常DFSC相比,炎症DFSC的成骨分化导致碱性磷酸酶(ALP)活性和茜素红S染色降低。另外,炎症和正常DFSCs的体内移植表明牙周炎DFSCs严重损害了骨生成。通过液相色谱与串联质谱联用进行蛋白质谱分析以分析发炎组织和正常组织中蛋白质表达的差异。炎症和正常DFSC的比较显示转化生长因子(TGF)-β2的表达水平的显著变化。牙龈卟啉单胞菌(P.g)衍生的脂多糖(LPS)用于产生类似于牙周炎的体外炎性病症。LPS处理的DFSCs的成骨分化受到抑制,细胞表现出低水平的TGF-β1和高水平的TGF-β2。TGF-β2抑制剂处理的DFSCs显示茜素红S染色和ALP活性明显增加。抑制TGF-β2后TGF-β1的表达也增加。

通过检查炎症的DFSCs和LPS触发的DFSCs,这些研究显示在炎性条件下发生的TGF-β2水平的增加可抑制骨形成。

原始出处:

Soyoun Um, Joo-Hee Lee, et al., TGF-β2 downregulates osteogenesis under inflammatory conditions in dental follicle stem cells. Int J Oral Sci. 2018 Sep; 10(3): 29.

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    2019-03-14 changhe713
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    2019-01-13 小几洁
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    2018-10-12 zhaojie88
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  6. [GetPortalCommentsPageByObjectIdResponse(id=2035879, encodeId=5da420358e93c, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Thu Mar 14 00:17:00 CST 2019, time=2019-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2020493, encodeId=fcbe202049319, content=<a href='/topic/show?id=1584134451c' target=_blank style='color:#2F92EE;'>#Oral#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13445, encryptionId=1584134451c, topicName=Oral)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIpeueeYB1kem1yfEZrSYKBdZBoqac9USf0RxIgRICBIyDn4licyiaiakNnobeCDVpvwqaWgwTNeLRHA/132, createdBy=bb5e2500127, createdName=小几洁, createdTime=Sun Jan 13 07:17:00 CST 2019, time=2019-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046589, encodeId=05cb20465894b, content=<a href='/topic/show?id=4499e795592' target=_blank style='color:#2F92EE;'>#细胞炎症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77955, encryptionId=4499e795592, topicName=细胞炎症)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Tue Jul 02 07:17:00 CST 2019, time=2019-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351856, encodeId=12f0135185698, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Fri Oct 12 14:17:00 CST 2018, time=2018-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441367, encodeId=d47a144136e98, content=<a href='/topic/show?id=58dd1e34591' target=_blank style='color:#2F92EE;'>#TGF-β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17345, encryptionId=58dd1e34591, topicName=TGF-β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=496f4824495, createdName=ms6980045490879608, createdTime=Fri Oct 12 14:17:00 CST 2018, time=2018-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=348812, encodeId=ae0c34881217, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Wed Oct 10 23:40:26 CST 2018, time=2018-10-10, status=1, ipAttribution=)]
    2018-10-10 orangesking

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