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BMC Med:近50万人数据揭示肉类摄入与25种常见疾病风险的关系

2021-04-09 MedSci原创 MedSci原创

高加工肉以及红肉摄入与结直肠癌风险增加有关。

目前的证据一致表明,高加工肉以及红肉摄入与结直肠癌风险增加有关。因此,包括世界卫生组织(WHO)和许多国家的饮食机构(如英国饮食指南)在内近年来建议减少红肉和加工肉的摄入。

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虽然肉类摄入量与癌症风险之间的关联已被全面研究,但关于肉类消费,尤其是禽肉与主要非癌症健康结果发生率之间关联的资料较少。虽然有几项前瞻性研究评估了未加工的红肉和加工肉摄入与血管疾病(CVD)和糖尿病风险的关系,但对于缺血性心脏病的证据并不明确,对于卒中亚型(如出血性卒中)的证据也有限。

鉴于关于肉类消摄入与许多常见的非癌症健康结果之间的关联的前瞻性证据有限。近期,来自英国牛津大学的专家研究了肉类摄入量与25种常见疾病(癌症除外)风险的关联。结果达标在最新的BMC Medicine杂志上。

研究人员使用了2006年至2010年期间招募到英国生物库(UK Biobank)研究的474985名中年人的数据,并跟踪到2017年(平均随访8.0年)。收集基线时肉类摄入量的现有信息、随访期间住院和死亡数据。同时对于一个约69000人的子样本使用在线的24小时回忆问卷重新记录了三次或更多次的饮食摄入量。

总的来说,经常食用肉类(每周3次及以上)的参与者比不太经常食用肉类的参与者有更多的不良健康行为和特征,而且在调整体重指数(BMI)后,观察到的大多数肉类摄入和健康风险的正向关联被大幅减弱。

未加工的红肉和加工肉的日摄入量每增加70克/天, 25种常见病的风险变化。

在经多重检验校正的多变量调整Cox回归模型中,未加工的红肉和加工肉摄入量每天多增加70g,缺血性心脏病风险增加15%,肺炎、憩室疾病、结肠息肉和糖尿病则各增加31%、19%、10%和30%。同时,单独摄入未加工红肉和加工肉的结果与上述相似。

单独摄入未加工红肉每增加50克/天,25种常见病的风险变化。

但是,单独摄入较多未加工红肉能降低缺铁性贫血(IDA)风险,每多摄入50g/d可降低20%。而较高的禽肉摄入量与较高的胃-食管反流病风险相关。禽肉类每多摄入30g/天,胃食管反流病风险增加17%,而胃、十二指肠炎、憩室疾病、胆囊疾病和糖尿病分别增加12%、10%、11%和14%,IDA风险则降低17%。

由此可见,较高的未加工红肉、加工肉和禽肉摄入增加几种常见病的风险,但未经加工的红肉和禽肉摄入能降低缺铁性贫血风险。

 

参考文献:

Papier, K., Fensom, G.K., Knuppel, A. et al. Meat consumption and risk of 25 common conditions: outcome-wide analyses in 475,000 men and women in the UK Biobank study. BMC Med 19, 53 (2021). https://doi.org/10.1186/s12916-021-01922-9

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    2021-04-10 ms2000002099164425

    666

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    2021-04-10 ms2000000719812611

    啊啊啊啊

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1975067, encodeId=dd0e19e50674a, content=<a href='/topic/show?id=f145355379' target=_blank style='color:#2F92EE;'>#BMC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3553, encryptionId=f145355379, topicName=BMC)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Mon Sep 20 08:02:11 CST 2021, time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1820449, encodeId=dfae1820449d8, content=<a href='/topic/show?id=c87f10089032' target=_blank style='color:#2F92EE;'>#风险的关系#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100890, encryptionId=c87f10089032, topicName=风险的关系)], attachment=null, authenticateStatus=null, createdAvatar=http://login.medsci.cn/upload/avatar/cc81592b507031e3cfd8d4c57911d98b/62c22832a9474aea1ca90ca058aebc03.jpg, createdBy=bed5446, createdName=limedical1974, createdTime=Fri Oct 01 18:02:11 CST 2021, time=2021-10-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473270, encodeId=216114e3270c3, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Sun Apr 11 14:02:11 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1610995, encodeId=9bd916109958c, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Apr 11 14:02:11 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955680, encodeId=8db5955680e3, content=666, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=23505477368, createdName=ms2000002099164425, createdTime=Sat Apr 10 13:14:05 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955661, encodeId=22f7955661f4, content=啊啊啊啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0fd45459665, createdName=ms2000000719812611, createdTime=Sat Apr 10 12:01:58 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955616, encodeId=a9c4955616c9, content=<a href='/topic/show?id=aa0582e6946' target=_blank style='color:#2F92EE;'>#肿瘤#</a>加工肉, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82769, encryptionId=aa0582e6946, topicName=肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=/img/user_icon.png, createdBy=8e6d5462230, createdName=鼠叔叔啦啦, createdTime=Sat Apr 10 05:42:22 CST 2021, time=2021-04-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955599, encodeId=1862955599e4, content=经常食用肉类(每周3次及以上)的参与者比不太经常食用肉类的参与者有更多的不良健康行为和特征,而且在调整体重指数(BMI)后,观察到的大多数肉类摄入和健康风险的正向关联被大幅减弱。, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210409/24a3c88bf27e42c89be15f164e992883/47fd023e77434094b3d596b55574979b.jpg, createdBy=7d082543841, createdName=12528eb6m08暂无昵称, createdTime=Fri Apr 09 23:53:48 CST 2021, time=2021-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=955595, encodeId=4ad1955595ff, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Fri Apr 09 23:05:56 CST 2021, time=2021-04-09, status=1, ipAttribution=)]
    2021-04-10 鼠叔叔啦啦

    #肿瘤#加工肉

    0

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    2021-04-09 12528eb6m08暂无昵称

    经常食用肉类(每周3次及以上)的参与者比不太经常食用肉类的参与者有更多的不良健康行为和特征,而且在调整体重指数(BMI)后,观察到的大多数肉类摄入和健康风险的正向关联被大幅减弱。

    0

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    2021-04-09 1209e435m98(暂无昵称)

    学习了,谢谢分享

    0

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炎性肠病又称炎症性肠病(IBD),为累及回肠、直肠、结肠的一种特发性肠道炎症性疾病。临床表现腹泻、腹痛,甚至可有血便。本病包括溃疡性结肠炎(UC)和克罗恩病(CD)。

Nutrients:肉类饮食会增加患癌风险

日前,一个国际研究团队发现,高摄入肉类食物的饮食方式已经同吸烟、酒精一样,是导致癌症发病率增高主要来源之一。这是世界卫生组织下面的一个国际癌症研究机构(International Agency for Research on Cancer)对自相关的癌症发病率统计时发现的,研究发表在Nutrients杂志上。【原文下载】 这项研究的数据是研究者对来自87个国家的男性和女性,患不同

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