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JAMA Pediatr:美国青少年阿片成瘾者药物治疗变化趋势

2017-06-22 zhangfan MedSci原创

研究调查了青年阿片类物质成瘾患者接受药物干预的变化趋势以及影响因素,但仅有1/4的患者及时接受了药物治疗

阿片类物质成瘾(OUD)通常开始于青春期或成年早期,通常需要早期干预与药物治疗。近日研究人员对美国青年人接受丁丙诺啡和纳曲酮治疗的时间变化趋势进行了研究。

该回顾性队列研究采用全国商业保险数据库数据,970万,13-25岁的青年人纳入研究。使用多因素逻辑回归分析相关药物随时间变化趋势,社会因素包括:性别、年龄、种族、社区教育和贫困水平、地理区域等。主要目的是考察阿片类物质成瘾后的6个月丁丙诺啡和纳曲酮使用情况。

共20822名青年人诊断为OUD(0.2%),65.8%为男性,82.2%为非西班牙裔白人,首次确诊年龄为21.0岁。2001-04年,OUD确诊率上升6倍 (每十万0.26至每十万1.51)。 共5580人 (26.8%)在6个月内接受药物治疗,其中4976 人(89.2%)接受丁丙诺啡,604人 (10.8%) 接受纳曲酮,药物治疗率从2002年的3%上涨至31.8%。多因素分析发现,年龄越小接受药物治疗的比例越低:13-15岁,1.4% (95% CI,0.4%-2.3%);16-17岁,9.7% (95% CI,8.4%-11.1%);18-20 岁,22.0% (95% CI,21.0%-23.0%);21-25 years,30.5% (95% CI,30.0%-31.5%)。女性药物治疗比例低于男性 20.3%vs 24.4%,非西班牙裔黑人药物治疗比例低于非西班牙裔白人14.8%vs23.1%。

研究调查了青年阿片类物质成瘾患者接受药物干预的变化趋势以及影响因素,但仅有1/4的患者及时接受了药物治疗。

原始出处:


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    2018-01-09 feather89
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    2017-06-23 天涯183

    非常好的文章,学习了,很受益

    0

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    2017-06-22 Y—xianghai

    学习了新知识

    0

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