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Thyroid:吸烟、饮酒与甲状腺癌风险

2020-03-09 xing.T MedSci原创

由此可见,甲状腺癌发生的风险与吸烟和饮酒成负相关。需要进一步研究以明确吸烟和饮酒对甲状腺癌发生发展发病机理的影响。

吸烟、饮酒与甲状腺癌之间的关联已在观察性研究中进行了评估,但结果仍存在争议。近日,甲状腺疾病领域权威杂志Thyroid上发表了一篇研究文章,在本研究中,研究人员分析了一项代表性数据的纵向队列研究,以确定吸烟、饮酒与甲状腺癌风险之间的关联,并根据年龄和性别调整风险。
 
研究人员从韩国国民健康保险数据库中确定了2009年参加健康筛查计划的20岁及以上的受试者,并对其进行随访,直至2017年。研究人员采用Cox比例风险模型估算了调整后的甲状腺癌风险比(aHR)。
 
 在平均随访8.33±0.57年期间,在9699104名参与者中,89527名(0.9%)参与者被诊断出患有甲状腺癌。与从未吸烟者相比,当前吸烟者[aHR为0.74,95%置信区间(CI)为0.72-0.76)]甲状腺癌的风险也有所降低,而既往吸烟者则无(aHR为0.98,95%CI为0.96-1.01)。当评估了参与者的每日吸烟量、吸烟时间和包年数时,吸烟与甲状腺癌的风险没有剂量反应关系。根据每周饮酒次数和每次饮酒的数量,甲状腺癌的风险降低(与非饮酒者相比,每周饮酒7次的HR为0.81,95%CI为0.74-0.88,饮用15杯以上的HR为0.87,95%CI为0.82-0.92)。与不饮酒的人相比,适当的饮酒似乎可以降低甲状腺癌的风险(≥40 g/周的HR为0.85,95%CI为0.81-0.89)。吸烟和饮酒之间的相互作用是显著的(相互作用p<0.0001)。
 
由此可见,甲状腺癌发生的风险与吸烟和饮酒成负相关。需要进一步研究以明确吸烟和饮酒对甲状腺癌发生发展发病机理的影响。

原始出处:

Yohwan Yeo,etal.Smoking, alcohol consumption, and the risk of thyroid cancer: a population-based Korean cohort study of 10 million people.Thyroid.2020.https://www.liebertpub.com/doi/10.1089/thy.2019.0508

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  1. [GetPortalCommentsPageByObjectIdResponse(id=963074, encodeId=9e0a9630e4f7, content=<a href='/topic/show?id=a6821e4254f' target=_blank style='color:#2F92EE;'>#Thyroid#</a>点击进入话题查看更多相关文章 或评论时插入话题加入讨论, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17425, encryptionId=a6821e4254f, topicName=Thyroid)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Thu May 06 13:43:52 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900012, encodeId=d35390001208, content=有意思,分享之!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=0cc51876313, createdName=ms4408957580485341, createdTime=Tue Nov 17 22:11:32 CST 2020, time=2020-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061914, encodeId=bd8d2061914c5, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Sep 19 19:30:04 CST 2020, time=2020-09-19, status=1, ipAttribution=)]
    2021-05-06 MedSciZeng

    #Thyroid#点击进入话题查看更多相关文章 或评论时插入话题加入讨论

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=963074, encodeId=9e0a9630e4f7, content=<a href='/topic/show?id=a6821e4254f' target=_blank style='color:#2F92EE;'>#Thyroid#</a>点击进入话题查看更多相关文章 或评论时插入话题加入讨论, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17425, encryptionId=a6821e4254f, topicName=Thyroid)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20221103/2796e00c9b4549e3b313ed9e7accc68f/b52d6d98bbe04782b5a4e2dd1ee80be2.jpeg, createdBy=078e1614372, createdName=MedSciZeng, createdTime=Thu May 06 13:43:52 CST 2021, time=2021-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=900012, encodeId=d35390001208, content=有意思,分享之!, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=0cc51876313, createdName=ms4408957580485341, createdTime=Tue Nov 17 22:11:32 CST 2020, time=2020-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2061914, encodeId=bd8d2061914c5, content=<a href='/topic/show?id=e6e1e15509f' target=_blank style='color:#2F92EE;'>#癌风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71550, encryptionId=e6e1e15509f, topicName=癌风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=docwu2019, createdTime=Sat Sep 19 19:30:04 CST 2020, time=2020-09-19, status=1, ipAttribution=)]
    2020-11-17 ms4408957580485341

    有意思,分享之!

    0

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