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Sci Rep:商业化阴道产品对尿路致病菌和阴道共生菌的影响

2020-05-27 AlexYang MedSci原创

一半的绝经后女性会发生更年期泌尿生殖系统综合征,因此许多女性会使用润滑阴道的产品。阴道产品对尿道致病菌和阴道共生菌的影响还不清楚。

一半的绝经后女性会发生更年期泌尿生殖系统综合征,因此许多女性会使用润滑阴道的产品。阴道产品对尿道致病菌和阴道共生菌的影响还不清楚。

最近,有研究人员评估了5种阴道产品(KY Jelly、Replens Silky Smooth lubricant、coconut oil、Replens Long-Lasting moisturizer 和Trimo-San)对大肠杆菌和卷曲乳杆菌生长和生存能力的影响。细菌是共培养产物,同时包括了阴道上皮细胞和选择的阴道用产品。研究人员使用未配对t检验或者ANOVA对细菌的生长进行了比较。研究发现,除了coconut oil之外,其他所有产品均能显著的抑制实验室株系和临床株系大肠杆菌的生长(p<0.02)。只有2种产品(Replens Long-Lasting moisturizer 和Trimo-San)能够显著的抑制卷曲乳杆菌的生长(p<0.01),而Replens Silky Smooth却能够刺激其生长(p<0.01)。阴道上皮细胞和选择的阴道产品能够消除产品对大肠杆菌的抑制作用。

最后,研究人员指出,阴道保湿和润滑产品的使用能够抑制大肠杆菌的生长,且该效应能够被阴道上皮细胞减弱。卷曲乳杆菌生长抑制反应要比大肠杆菌小。

原始出处:

Kristin J. Hung, Patricia L. Hudson, Agnes Bergerat et al. Effect of commercial vaginal products on the growth of uropathogenic and commensal vaginal bacteria. Sci Rep. 06 May 2020

 

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    2020-05-29 yeaweam
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