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Environ Health Perspect:胎儿期暴露于双酚A可促进肥胖的发生

2016-05-18 MedSci MedSci原创

Environ Health Perspect:胎儿期暴露于双酚A可促进肥胖的发生生命早期暴露于内分泌干扰物双酚A(BPA)或可促进肥胖的发生。但是人类中关于此关联的前瞻性十分有限。本研究旨在探究胎儿期及儿童早期BPA暴露是否与儿童肥胖有关。研究人员采集了尿液样本以测量胎儿期(n = 375)、3岁儿童(n = 408)及5岁儿童(n= 518)BPA的浓度。同时测量儿童童年人体测量学和生物电阻抗

Environ Health Perspect:胎儿期暴露于双酚A可促进肥胖的发生

生命早期暴露于内分泌干扰物双酚A(BPA)或可促进肥胖的发生。但是人类中关于此关联的前瞻性十分有限。本研究旨在探究胎儿期及儿童早期BPA暴露是否与儿童肥胖有关。

研究人员采集了尿液样本以测量胎儿期(n = 375)、3岁儿童(n = 408)及5岁儿童(n= 518)BPA的浓度。同时测量儿童童年人体测量学和生物电阻抗的结果,包括5岁及7岁时的身体质量指数Z值(BMIZ),以及7岁时的脂肪质量指数(FMI)、体脂百分比(%BF)和腰围(WC)。采用多元线性回归分析模型分析数据。

结果发现,胎儿期尿液中双酚A的浓度与儿童7岁时的FMI、%BF和WC正相关,但与BMIZ并无此关联,也与儿童5岁和7岁时BMIZ的变化无关。FMI的结果具有性别特异性。儿童尿液中双酚A的浓度与儿童人体测量结果无关。

总而言之,该研究发现胎儿期尿液中双酚A的浓度与FMI、%BF和WC有关。该研究结果表明,胎儿期暴露于双酚A或可促进肥胖的发生,这与既往的研究结果一致,需提高公众对BPA的广泛关注。

原始出处:

Lori A. Hoepner, Robin M. Whyatt, et al., Bisphenol A and Adiposity in an Inner-City Birth Cohort. Environ Health Perspect; DOI:10.1289/EHP205.

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    2016-12-11 feather89
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    2017-01-23 仁者大医
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    2016-09-09 shizhenshan
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    2016-05-20 zhaojie88
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    2016-05-20 july_979
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