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AUTOPHAGY:棉花种子提取物引发胶质瘤细胞死亡

2018-07-23 海北 MedSci原创

AT 101([ - ] - 棉酚)是一种来自棉花种子的天然化合物,其在胶质瘤细胞中诱导ACD。通过ATG5的CRISPR / Cas9敲除证实,其在AT 101处理后能够部分但显着地促进细胞存活。

在大多数情况下,巨自噬/自噬用于缓解细胞应激并以促生存的方式起作用。然而,自噬的影响是和其作用环境高度相关的,自噬细胞死亡(ACD)正在成为压力和药物诱导的细胞死亡的替代范例。
AT 101([ - ] - 棉酚)是一种来自棉花种子的天然化合物,其在胶质瘤细胞中诱导ACD。通过ATG5的CRISPR / Cas9敲除证实,其在AT 101处理后能够部分但显着地促进细胞存活。
AT 101处理的U87MG和U343神经胶质瘤细胞的全蛋白质组学分析显示,线粒体蛋白质簇强烈减少,而HMOX1(血红素加氧酶1)强烈上调。AT 101能够快速触发线粒体膜去极化,使线粒体被自噬体吞噬,并且线粒体数量和蛋白质的显着减少不依赖于BAX和BAK1的存在。
相反,AT 101诱导的线粒体数量减少可以通过渥曼青霉素,巴弗洛霉素A1和氯喹的处理抑制自噬来逆转。 HMOX1和线粒体受体BNIP3(BCL2相互作用蛋白3)和BNIP3L(BCL2相互作用蛋白3样)的沉默显着减弱了AT101依赖性线粒体自噬和细胞死亡。
总之,这些数据表明早期线粒体功能障碍和HMOX1过度活化协同作用,触发致死性线粒体自噬,这有助于AT 101在胶质瘤细胞中的细胞杀伤作用。

原始出处:
Nina Meyer et al. AT 101 induces early mitochondrial dysfunction and HMOX1 (heme oxygenase 1) to trigger mitophagic cell death in glioma cells. AUTOPHAGY 2018, DOI: https://doi.org/10.1080/15548627.2018.1476812

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createdName=龙胆草, createdTime=Mon Jul 23 08:16:25 CST 2018, time=2018-07-23, status=1, ipAttribution=)]
    2018-09-21 大爰

    学习了谢谢分享!!

    0

  3. 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createdName=龙胆草, createdTime=Mon Jul 23 08:16:25 CST 2018, time=2018-07-23, status=1, ipAttribution=)]
    2018-09-09 大爰

    学习了谢谢分享!!

    0

  4. 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createdName=大爰, createdTime=Fri Aug 31 07:57:38 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340599, encodeId=216534059909, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Aug 24 22:06:16 CST 2018, time=2018-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339369, encodeId=b9d233936945, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Aug 18 17:43:04 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335096, encodeId=e684335096dc, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Jul 30 09:57:06 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333818, encodeId=4b91333818fd, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Tue Jul 24 09:31:01 CST 2018, time=2018-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333536, encodeId=bd31333536bd, content=学习了!!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Mon Jul 23 08:29:57 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333526, encodeId=59d2333526b5, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Jul 23 08:16:25 CST 2018, time=2018-07-23, status=1, ipAttribution=)]
    2018-08-31 大爰

    学习了谢谢分享!!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1980362, encodeId=aa041980362cb, content=<a href='/topic/show?id=f49e840e104' target=_blank style='color:#2F92EE;'>#胶质瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84071, encryptionId=f49e840e104, topicName=胶质瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=649f191, createdName=zzc2211, createdTime=Thu Jan 17 22:55:00 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345995, encodeId=054d345995fa, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Sep 21 09:56:59 CST 2018, time=2018-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=344119, encodeId=608d344119c3, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Sep 09 08:20:56 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=341921, encodeId=6fc4341921b3, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Aug 31 07:57:38 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340599, encodeId=216534059909, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Aug 24 22:06:16 CST 2018, time=2018-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339369, encodeId=b9d233936945, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Aug 18 17:43:04 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335096, encodeId=e684335096dc, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Jul 30 09:57:06 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333818, encodeId=4b91333818fd, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Tue Jul 24 09:31:01 CST 2018, time=2018-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333536, encodeId=bd31333536bd, content=学习了!!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Mon Jul 23 08:29:57 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333526, encodeId=59d2333526b5, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Jul 23 08:16:25 CST 2018, time=2018-07-23, status=1, ipAttribution=)]
    2018-08-24 大爰

    学习并分享!!

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1980362, encodeId=aa041980362cb, content=<a href='/topic/show?id=f49e840e104' target=_blank style='color:#2F92EE;'>#胶质瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84071, encryptionId=f49e840e104, topicName=胶质瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=649f191, createdName=zzc2211, createdTime=Thu Jan 17 22:55:00 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345995, encodeId=054d345995fa, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Sep 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createdName=大爰, createdTime=Fri Aug 31 07:57:38 CST 2018, time=2018-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=340599, encodeId=216534059909, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Aug 24 22:06:16 CST 2018, time=2018-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=339369, encodeId=b9d233936945, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sat Aug 18 17:43:04 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335096, encodeId=e684335096dc, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Jul 30 09:57:06 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333818, encodeId=4b91333818fd, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Tue Jul 24 09:31:01 CST 2018, time=2018-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333536, encodeId=bd31333536bd, content=学习了!!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Mon Jul 23 08:29:57 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333526, encodeId=59d2333526b5, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Jul 23 08:16:25 CST 2018, time=2018-07-23, status=1, ipAttribution=)]
    2018-08-18 大爰

    学习并分享!!

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1980362, encodeId=aa041980362cb, content=<a href='/topic/show?id=f49e840e104' target=_blank style='color:#2F92EE;'>#胶质瘤细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84071, encryptionId=f49e840e104, topicName=胶质瘤细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=649f191, createdName=zzc2211, createdTime=Thu Jan 17 22:55:00 CST 2019, time=2019-01-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=345995, encodeId=054d345995fa, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Fri Sep 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createdBy=09431951290, createdName=大爰, createdTime=Sat Aug 18 17:43:04 CST 2018, time=2018-08-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=335096, encodeId=e684335096dc, content=学习并分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Mon Jul 30 09:57:06 CST 2018, time=2018-07-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333818, encodeId=4b91333818fd, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Tue Jul 24 09:31:01 CST 2018, time=2018-07-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333536, encodeId=bd31333536bd, content=学习了!!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Mon Jul 23 08:29:57 CST 2018, time=2018-07-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=333526, encodeId=59d2333526b5, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Jul 23 08:16:25 CST 2018, time=2018-07-23, status=1, ipAttribution=)]
    2018-07-30 大爰

    学习并分享!!

    0

  8. 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createdName=龙胆草, createdTime=Mon Jul 23 08:16:25 CST 2018, time=2018-07-23, status=1, ipAttribution=)]
    2018-07-24 flysky120

    学习一下知识了

    0

  9. 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createdName=龙胆草, createdTime=Mon Jul 23 08:16:25 CST 2018, time=2018-07-23, status=1, ipAttribution=)]
    2018-07-23 zb1235672

    学习了!!!!!

    0

  10. 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createdName=龙胆草, createdTime=Mon Jul 23 08:16:25 CST 2018, time=2018-07-23, status=1, ipAttribution=)]
    2018-07-23 龙胆草

    学习谢谢分享

    0

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