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婴儿体表及肠道微生物群影响其今后患病风险

2016-01-03 QQduhp 译 MedSci原创

在Birth Defects Research Part C:Embryo Today杂志中,克利夫兰儿童医院的Sharon Meropol博士和同事针对微生物组与儿童疾病的关系这一论点开展了研究。微生物群是指数以万亿的生活在我们的肠道、呼吸道和皮肤表面的微生物。 越来越多的证据表明,在人的生命早期破坏器微生物群可能会影响其日后的发展,并增加罹患某些疾病的可能性。今年早些时候,一项研究表明,在婴儿

在Birth Defects Research Part C:Embryo Today杂志中,克利夫兰儿童医院的Sharon Meropol博士和同事针对微生物群与儿童疾病的关系这一论点开展了研究。

微生物群是指数以万亿的生活在我们的肠道、呼吸道和皮肤表面的微生物。 

越来越多的证据表明,在人的生命早期破坏儿童的微生物群可能会影响其日后的发展,并增加罹患某些疾病的可能性。今年早些时候,一项研究表明,在婴儿3个月大时若丰富其肠道细菌种类,那么他们在1岁时出现食物过敏的风险则会降低。 

Meropol解释道,微生物群紊乱可能导致众多儿童疾病如过敏、哮喘、肥胖和自闭症样神经发育紊乱等。 

许多新近研究表明,很多因素可能有助于丰富孩子体表及肠道的微生物群如母乳喂养、阴道分娩和出生后母婴皮肤直接接触。 

去年的一项研究表明,母乳喂养可以丰富婴儿体内的微生物群,以帮助婴儿更好地成长。 

过去人们普遍认为,新生儿是出生后开始拥有微生物群的,因母体子宫是无菌。 

然而,最近的研究表明,肠道微生物群的出现始于出生之前。Meropol博士和他的同事们指出,越来越多的证据表明,儿童微生物群始于在母体子宫时。

加拿大阿尔伯塔大学Petya T. Koleva博士和他的同事们发现,对于有过敏史的女性而言,她们的孩子出生后粪便中大肠杆菌更多,因此孩子们今后患呼吸系统疾病的风险增加。Meropol博士认为,这表明研究人员不仅需要考虑婴儿的微生物群,也需要考虑他们母亲的微生物群。

我们的一些现代医学技术可以影响他们体内及体表的微生物群,并影响儿童的免疫、代谢和神经系统。她认为,婴儿和儿童医院的医务人员使用配方奶粉喂养婴儿、剖腹产、免疫接种、使用抗生素等现代干预可能对新生儿的肠道微生物群产生负面影响。 

现有证据表明,孕产妇和婴儿肠道菌群可以影响孩子的疾病风险,但是博士认为,这项研究到目前为止所得的发现只是触及表面的,是九牛一毛。 

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    2017-05-20 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

    0

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    2016-02-16 mengli1984

    想法挺新颖

    0

  4. 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createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KwlM29ic8TDJMJOiarryMIZZhTjXxyRT9lffSWpWWcWojnL7ibJwcOn99ayict8FJ9ICYmNh9swD6R4E/0, createdBy=196f1683049, createdName=收获你的美, createdTime=Tue Feb 02 18:46:00 CST 2016, time=2016-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=62912, encodeId=7b68629122d, content=收了, beContent=null, objectType=article, channel=null, level=null, likeNumber=146, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5KwlM29ic8TDJMJOiarryMIZZhTjXxyRT9lffSWpWWcWojnL7ibJwcOn99ayict8FJ9ICYmNh9swD6R4E/0, createdBy=196f1683049, createdName=收获你的美, createdTime=Tue Feb 02 18:46:00 CST 2016, time=2016-02-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=59083, encodeId=556559083dc, content=共存亡, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Sun Jan 24 21:36:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=56112, encodeId=7a2d5611278, content=免疫接种也有负面影响,但是孩子要接种那么多种疫苗, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLRP2D8sTDxkrGNjMqwyLUGd9Wbt6L0Yw9goia4ibPGLEx48lF9kvw86FKicbdWemTqujrf6K5WPIic8g/132, createdBy=69a11636814, createdName=ssummer, createdTime=Tue Jan 12 08:48:00 CST 2016, time=2016-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55719, 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href='/topic/show?id=2088816e487' target=_blank style='color:#2F92EE;'>#肠道微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81674, encryptionId=2088816e487, topicName=肠道微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Tue Jan 05 09:09:00 CST 2016, time=2016-01-05, status=1, ipAttribution=)]
    2016-02-02 收获你的美

    0

  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Sun Jan 24 21:36:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=56112, encodeId=7a2d5611278, content=免疫接种也有负面影响,但是孩子要接种那么多种疫苗, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLRP2D8sTDxkrGNjMqwyLUGd9Wbt6L0Yw9goia4ibPGLEx48lF9kvw86FKicbdWemTqujrf6K5WPIic8g/132, createdBy=69a11636814, createdName=ssummer, createdTime=Tue Jan 12 08:48:00 CST 2016, time=2016-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55719, 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href='/topic/show?id=2088816e487' target=_blank style='color:#2F92EE;'>#肠道微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81674, encryptionId=2088816e487, topicName=肠道微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Tue Jan 05 09:09:00 CST 2016, time=2016-01-05, status=1, ipAttribution=)]
    2016-02-02 收获你的美

    收了

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTK29w9r0upRgxUXHNhe7bd3VxHnhBSpibMbKOjtX92zXr78SkuZfUNuADrjHiaw6uibZaEYjh9cJLzew/132, createdBy=261e1682638, createdName=1de3b290m83(暂无匿称), createdTime=Sun Jan 24 21:36:00 CST 2016, time=2016-01-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=56112, encodeId=7a2d5611278, content=免疫接种也有负面影响,但是孩子要接种那么多种疫苗, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTLRP2D8sTDxkrGNjMqwyLUGd9Wbt6L0Yw9goia4ibPGLEx48lF9kvw86FKicbdWemTqujrf6K5WPIic8g/132, createdBy=69a11636814, createdName=ssummer, createdTime=Tue Jan 12 08:48:00 CST 2016, time=2016-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=55719, encodeId=058c55e199c, content=好棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=df9e1651052, createdName=三三五五, createdTime=Mon Jan 11 12:51:00 CST 2016, time=2016-01-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281739, encodeId=c2791281e3953, content=<a href='/topic/show?id=ef315299070' target=_blank style='color:#2F92EE;'>#患病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52990, encryptionId=ef315299070, topicName=患病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0045169, createdName=木头人513, createdTime=Tue Jan 05 09:09:00 CST 2016, time=2016-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298828, encodeId=6dad129882818, content=<a href='/topic/show?id=2088816e487' target=_blank style='color:#2F92EE;'>#肠道微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81674, encryptionId=2088816e487, topicName=肠道微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Tue Jan 05 09:09:00 CST 2016, time=2016-01-05, status=1, ipAttribution=)]
    2016-01-24 1de3b290m83(暂无匿称)

    共存亡

    0

  7. 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    2016-01-12 ssummer

    免疫接种也有负面影响,但是孩子要接种那么多种疫苗

    0

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href='/topic/show?id=2088816e487' target=_blank style='color:#2F92EE;'>#肠道微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81674, encryptionId=2088816e487, topicName=肠道微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Tue Jan 05 09:09:00 CST 2016, time=2016-01-05, status=1, ipAttribution=)]
    2016-01-11 三三五五

    好棒

    0

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Gut:提高人体结肠中丙酸盐含量,可以抵制体重增长

过去25年,研究者广泛认可这一观点——源自胃肠道的激素和神经信号机制在调节人体能量代谢方面,起非常重要的作用。越来越多的研究也证明肠道菌群环境可以影响人体的能量平衡和肥胖症的发展。结肠微生物群可以酵解膳食纤维,生成短链脂肪酸。最近有研究证明,短链脂肪酸丙酸盐可能在机体食欲调节中起重要的作用。[pdf free]由此,Edward S Chambers和他的团队,提出了一个大胆的设想,并且成功验证了

PNAS:微生物群预示早产的发生

寄居在孕妇生殖道的亿万微生物可能是预测胎儿是否会早产的关键。众所周知,微生物覆盖我们身体外表和消化道、泌尿道等等众多地方,它们对我们而言有着无可替代的作用。发表在《美国国家科学院院刊》的一项研究结果揭示了微生物和微生物群对预测孕妇是否会早产中具有重要作用。妊娠周数小于37周胎儿分娩则定义该胎儿为早产。据WHO统计,全球大概有1500万早产儿/年,且数量还在持续上升。目前早产并发症是全球5岁以下儿童

STM:鼻腔中微生物群的改变或触发慢性鼻窦炎

据一项新的研究报告,鼻腔中微生物群的改变可能会触发慢性鼻窦问题。到目前为止,对鼻窦感染的治疗的目的一直是要将细菌从鼻窦中消除。然而,这些发现提示,在鼻窦中重新植入细菌可能对慢性鼻窦炎患者有益。Nicole Abreu及其同事对一小组接受了矫正性鼻腔手术的慢性鼻窦炎患者以及一组没有鼻窦问题但却因为与鼻窦无关的问题而接受手术的病人的微生物群落概况进行了检测。由于这些菌落中的大部分的细菌无法在常规的实验

抗生素防腐剂使人体微生物环境百年内发生巨变

  在过去100年内,广泛使用各种防腐剂和抗生素使人体内微生物生态环境发生了很大变化。   据国外媒体12月14日报道,美国俄克拉荷马大学的科学家近日研究发现,广泛使用各种防腐剂和抗生素使人体内微生物生态环境在过去100年内发生了很大的变化。   研究古人类的体内微生物群对于了解现代人的健康变化至关重要。俄克拉荷马大学分子人类学实验室的主任塞西尔·M.刘易斯(Cecil M. Lewis Jr

PLoS ONE:胃肠道不同区段的微生物群落结构特征组成

工学院吴晓磊教授与北京大学第三医院段丽萍教授课题组联合发表的论文“Bacterial Community Mapping of the Mouse Gastrointestinal Tract”(Gu et al, PLoS ONE 8(10): e74957. doi:10.1371/journal.pone.0074957)近日被英国医学与生物学论文评价和检索系统Faculty of 1000

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