CLIN CANCER RES：PD-L1表达与黑色素瘤免疫逃逸

2017-10-29 MedSci MedSci原创

CLIN CANCER RES近期发表了一篇文章，研究接受靶向MAPK抑制剂治疗的黑色素瘤治疗前和治疗汇总的免疫活性、PD-L1表达和肿瘤信号情况。

CLIN CANCER RES近期发表了一篇文章，研究接受靶向MAPK抑制剂治疗的黑色素瘤治疗前和治疗汇总的免疫活性、PD-L1表达和肿瘤信号情况。作者分析了17名已知PD-L1表达情况且接受BRAF抑制剂（n=12）或BRAF/MEK联合抑制治疗的黑色素瘤患者的38例肿瘤标本。在治疗前（PRE，n=17）、治疗早期（EDT，n=8），和进展期（PROG，n=13）标本中分析RNA表达，并使用免疫组化分析HLA-A/HLA-DPB1表达。治疗前、治疗早期和进展期标本基因富集分析表明免疫细胞活性指标与PD-L1染色具有强烈的正相关关系。与之相反，MAPK信号和Wnt/β-catenin活性与黑色素瘤PD-L1表达负相关。PD-L1表达和免疫活性特征不能简单地反应出免疫细胞浸润程度或免疫细胞类型，不能有效评估肿瘤对MAPK抑制的反应。文章最后认为，黑色素瘤中PD-L1表达与免疫细胞和免疫活性特征有关，但是不能有效地反应出肿瘤对MAPK抑制的反应，因为许多治疗前和进展期标本同时出现PD-L1阳性和免疫活性特征。这表明在接受MAPK抑制剂治疗的肿瘤中免疫逃逸是常见的。这一发现对二线免疫治疗的选

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#插入话题

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2018-04-27 sunylz

#色素#

100 0
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2017-12-27 lxg951

#PD-L1表达#

71 0
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2017-10-31 smartjoy

#PD-L1#

85 0
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2017-10-31 cqlidoudou

#黑色素#

119 0
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2017-10-31 cqlidoudou

#黑色素#

0 0
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2017-10-29 戒馋，懒，贪

谢谢分享.学习了

107 0
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2017-10-29 1ddf0692m34(暂无匿称)

学习了.涨知识

130 0
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2017-10-29 swfzhanggui

分享了.学习了.了解肿瘤新机制.为患者服务

100 0

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