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Gut:经内镜发现的食管腺癌患者预后更好

2016-07-15 Seven L 译 MedSci原创

近期发表在Gut的一项队列研究结果表明,对于发展为食管腺癌(EAC)的Barrett’s食管(BE)患者,如果是通过内镜监测发现癌症,那么患者的预后会更好。休斯敦贝勒医学院的Hashem B. El-Serag博士对2003-2009年确诊的29536例BE患者进行了研究。若有影响整体生存的并发症则排除在外。在平均5年的随访期间,424例发展为EAC,其中49.3%的患者通过内镜监测发现癌症;非B

近期发表在Gut的一项队列研究结果表明,对于发展为食管腺癌(EAC)的Barrett’s食管(BE)患者,如果是通过内镜监测发现癌症,那么患者的预后会更好。

休斯敦贝勒医学院的Hashem B. El-Serag博士对2003-2009年确诊的29536例BE患者进行了研究。若有影响整体生存的并发症则排除在外。

在平均5年的随访期间,424例发展为EAC,其中49.3%的患者通过内镜监测发现癌症;非BE内镜监测发现的EAC患者中,有17.2%是内镜监测失败。

内镜与非内镜诊断EAC的患者相比,诊断时更有可能是0或1期癌症(74.7% vs. 56.2%; P < .001),有更长的生存时间(中位数 3.2 vs. 2.3年; P < .001),有更低的癌症相关死亡率(34% vs. 54%; P < .0001);虽然进行食管切除术的比例更高,但是没有统计学意义 (51.2% vs. 42.3%; P = .07)。

多元Cox比例风险模型显示,BE内镜监测与癌症相关死亡率的下降有关(HR = 0.47; 95% CI, 0.35-0.64),其中很大部分原因归因于EAC的早期诊断。

多变量分析显示,监测与非监测患者相比,校正后的整体死亡HR=0.63 (95% CI, 0.47-0.84)。

研究表明,对于EAC患者,因为BE进行内镜监测而发现EAC与更好的预后有关。是否对所有患者进行内镜监测,还需要以后更多的收益研究。

原始出处:

El-Serag HB, et al. Surveillance endoscopy is associated with improved outcomes of oesophageal adenocarcinoma detected in patients with Barrett's oesophagus .Gut. 2016;doi:10.1016/j.cgh.2016.06.018.

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    2016-07-18 doctorJiangchao

    大家以前就认同了

    0

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createdBy=d0921674448, createdName=gyczyxy, createdTime=Sat Jul 16 12:39:00 CST 2016, time=2016-07-16, status=1, ipAttribution=)]
    2016-07-18 doctorJiangchao

    早发现 早诊断 早治疗 预后好

    0

  5. 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    2016-07-17 zhouqu_8
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createdBy=d0921674448, createdName=gyczyxy, createdTime=Sat Jul 16 12:39:00 CST 2016, time=2016-07-16, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1820996, encodeId=a15b182099669, content=<a href='/topic/show?id=3488101119e7' target=_blank style='color:#2F92EE;'>#食管腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101119, encryptionId=3488101119e7, topicName=食管腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bb182500058, createdName=yuhaisheng_ibp_32061711, createdTime=Tue Aug 23 00:19:00 CST 2016, time=2016-08-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1691880, encodeId=ac5f169188085, content=<a href='/topic/show?id=a450530853c' target=_blank style='color:#2F92EE;'>#患者预后#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53085, encryptionId=a450530853c, topicName=患者预后)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8f4729287700, createdName=bnurmamat, createdTime=Wed Feb 08 14:19:00 CST 2017, time=2017-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93414, encodeId=f3a793414e4, content=大家以前就认同了, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Mon Jul 18 22:18:00 CST 2016, time=2016-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93413, encodeId=d1559341310, content=早发现 早诊断 早治疗 预后好, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdName=ms7899726347904398, createdTime=Sun Jul 17 13:19:00 CST 2016, time=2016-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93195, encodeId=eae69319566, content=内镜治疗很好的评估, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Sat Jul 16 16:28:00 CST 2016, time=2016-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93186, encodeId=798f93186d3, content=相当于普查早发现早诊断,预后肯定好,这文章发的好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=d0921674448, createdName=gyczyxy, createdTime=Sat Jul 16 12:39:00 CST 2016, time=2016-07-16, status=1, ipAttribution=)]
    2016-07-16 医路开来

    内镜治疗很好的评估

    0

  9. 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style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Sun Jul 17 13:19:00 CST 2016, time=2016-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1512273, encodeId=aac015122e3d2, content=<a href='/topic/show?id=f797101120d6' target=_blank style='color:#2F92EE;'>#食管腺癌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101120, encryptionId=f797101120d6, topicName=食管腺癌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6a7410453390, createdName=ms7899726347904398, createdTime=Sun Jul 17 13:19:00 CST 2016, time=2016-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93195, encodeId=eae69319566, content=内镜治疗很好的评估, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NfdY7yem1P7bRvOP6z0jKsBoYR8ezfAricY7meQWcte7LRJsWHVn0CnPJg2JuQmevR0DoFmmEib5QLD2kNESBESQT/0, createdBy=59191706502, createdName=医路开来, createdTime=Sat Jul 16 16:28:00 CST 2016, time=2016-07-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=93186, encodeId=798f93186d3, content=相当于普查早发现早诊断,预后肯定好,这文章发的好!, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=d0921674448, createdName=gyczyxy, createdTime=Sat Jul 16 12:39:00 CST 2016, time=2016-07-16, status=1, ipAttribution=)]
    2016-07-16 gyczyxy

    相当于普查早发现早诊断,预后肯定好,这文章发的好!

    0

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