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JAHA:抑郁症状对心房纤颤的负面影响和风险

2018-12-27 xing.T MedSci原创

由此可见,抑郁症状与AF事件风险增加有关。进一步研究需要明确改善抑郁症状是否可降低AF发病率,这一点很重要。

目前关于抑郁症与其它心房颤动(AF)负面影响指标之间前瞻性关系的文献十分有限。近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,在多民族中老年人群队列中,研究人员旨在确定抑郁、愤怒、焦虑和慢性压力与AF事件之间的关系。

该分析纳入了在基线时没有AF的6644名MESA(动脉粥样硬化多种族研究)研究的参与者。在基线时研究人员评估了参与者的抑郁症状,通过20项流行病学研究中心抑郁量表评分≥16或使用抗抑郁药物来进行定义。研究人员采在基线时采用Spielberger特质愤怒量表、Spielberger特质焦虑量表和慢性负荷量表以分别评估愤怒、焦虑和慢性压力。该研究的主要结局是AF事件,通过随访心电图、出院诊断或医疗保险索赔的数据来确定。

在接近13年的中位随访期间,共检出875例(13%)AF事件。在单独调整后的Cox比例风险分析中,流行病学研究中心抑郁量表评分≥16(对照组流行病学研究中心抑郁量表评分<2)和抗抑郁药使用与AF风险之间相关,风险分别增加34%和36%(流行病学研究中心抑郁量表≥16的风险比为1.34; 95%CI为1.04-1.74;使用抗抑郁药的风险比为1.36; 95%CI为1.04-1.77)。愤怒、焦虑或慢性压力与AF的发生发展无明显关联。

由此可见,抑郁症状与AF事件风险增加有关。进一步研究需要明确改善抑郁症状是否可降低AF发病率,这一点很重要。

原始出处:

Parveen K. Garg.et al.Negative Affect and Risk of Atrial Fibrillation: MESA.JAHA.2018.https://www.ahajournals.org/doi/10.1161/JAHA.118.010603

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    2019-01-01 smartxiuxiu

    抑郁症对什么没影响?

    0

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    2018-12-31 医者仁心5538

    学习了

    0

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    2018-12-29 zhaohui6731
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    2018-12-29 sodoo

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