JCEM：体重指数和COVID-19患者诊断、住院和死亡风险的关系

2021-07-24 MedSci原创 MedSci原创

BMI与COVID-19诊断和住院风险之间存在关联，但与死亡率呈J型关联。

体重指数(BMI)与COVID-19之间的关联缺乏全面的了解。

近日，内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章，该研究旨在调查BMI与COVID-19诊断、COVID-19住院和COVID-19诊断或住院后死亡风险之间的关联（随后的死亡），并考虑到对年龄和性别进行调整后的潜在影响。

这项基于人群的队列研究，超过80%的加泰罗尼亚人初级保健记录，与2020年3月至5月期间的区域范围测试、医院和死亡率记录相关联。参与者为体重和身高至少测量一次的成人（≥18岁）。该研究的主要结果指标为每个结果的风险比(HR)。

与体重指数相关的COVID-19结局风险比

该研究纳入了2524926名参与者。经过67天的随访，57443人被诊断出患有COVID-19，10862人因COVID-19住院，2467人随后死亡。BMI与COVID-19的诊断和住院呈正相关。与BMI为22kg/m2的参与者相比，BMI为31kg/m2的参与者COVID-19诊断的HR(95%CI)为1.22(1.19-1.24)，不伴有和伴有先前COVID-19门诊诊断的情况下住院HR分别为1.88(1.75-2.03)和2.01(1.86-2.18)。BMI与随后的COVID-19死亡之间的关联呈J形，BMI≤19kg/m2的个体死亡风险略高，而BMI≥40kg/m2的风险增加更为明显。COVID-19的风险增加结果在年轻患者中尤为明显。

由此可见，BMI与COVID-19诊断和住院风险之间存在关联，但与死亡率呈J型关联。需要更多的研究来解开这些关联背后的机制。

原始出处：

Martina Recalde.et al.Body mass index and risk of COVID-19 diagnosis, hospitalisation, and death: a cohort study of 2 524 926 Catalans.JCEM.2021.https://doi.org/10.1210/clinem/dgab546

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2021-11-11 limedical1974

#风险的关系#

57 0
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2021-10-20 smallant2015

#JCEM#

68 0
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2021-08-06 achengzhao

#JCE#

53 0
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2021-07-26 quxin068

#死亡风险#

54 0
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2021-07-26 zhangph

#COVID-19患者#

90 0
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2021-07-24 @gxl

非常受用

77 0
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2021-07-24 120ad718m67

学习了

93 0
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2021-07-24 liuhuan00422

体重指数(BMI)与COVID-19之间的关联

82 0

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JCEM：体重指数和COVID-19患者诊断、住院和死亡风险的关系

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