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Clinica Chimica Acta：新型PHI诺模图的开发和内部验证以识别侵袭性前列腺癌

2020-03-19 MedSci原创 MedSci原创

侵袭性前列腺癌
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前列腺健康指数(PHI)是一种新的前列腺癌(PCa)检测方法，提高了总PSA (tPSA)的表现，并与肿瘤的侵袭性有关。本研究目的是在包含PHI的多变量模型的基础上构建诺模列线图。

前列腺健康指数(PHI)是一种新的前列腺癌(PCa)检测方法，提高了总PSA (tPSA)的表现，并与肿瘤的侵袭性有关。本研究目的是在包含PHI的多变量模型的基础上构建诺模列线图，以估计侵袭性PCa的个体可能性。

研究人员选择了276名活检对象，其中包括151名PCa患者。采用D 'Amico标准将这些患者分为三组，这三组与进展风险相关。将中度和高危PCa认为是侵袭性PCa。利用实验室(tPSA、%fPSA、%p2PSA、PHI)和临床变量建立了预测侵袭性PCa的多变量模型。以临床使用的列线图表示最佳预测模型以图形形式。

研究结果显示，年龄、直肠指检、tPSA、%fPSA、PHI、前列腺体积等多变量模型的准确性最高(AUC: 0.815)。DCA证实了诺模列线图的有效性，与包括年龄、直肠指检和tPSA的基础模型相比，其临床净获益(大于7%)更高。

研究结果表明，基于PHI诺模图是检测侵袭性PCa的有效工具。

原始出处：

L. Foj，X. Filella，Development and internal validation of a novel PHI-nomogram to identify aggressive prostate cancer

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    2020-08-24 windight

    #CTA#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1849882, encodeId=67971849882f3, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Mon Aug 24 16:10:05 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366359, encodeId=c2081366359cd, content=<a href='/topic/show?id=186126998e2' target=_blank style='color:#2F92EE;'>#侵袭性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26998, encryptionId=186126998e2, topicName=侵袭性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Sat Mar 21 01:10:05 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463982, encodeId=c613146398253, content=<a href='/topic/show?id=e58691932b6' target=_blank style='color:#2F92EE;'>#诺模图#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91932, encryptionId=e58691932b6, topicName=诺模图)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13c36558142, createdName=zhangyxzsh, createdTime=Sat Mar 21 01:10:05 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040685, encodeId=d7181040685a3, content=前列腺癌相关研究，学习了，谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Mar 19 13:10:05 CST 2020, time=2020-03-19, status=1, ipAttribution=)]
    2020-03-21 sunyl07

    #侵袭性#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1849882, encodeId=67971849882f3, content=<a href='/topic/show?id=61815385aa' target=_blank style='color:#2F92EE;'>#CTA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Mon Aug 24 16:10:05 CST 2020, time=2020-08-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366359, encodeId=c2081366359cd, content=<a href='/topic/show?id=186126998e2' target=_blank style='color:#2F92EE;'>#侵袭性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26998, encryptionId=186126998e2, topicName=侵袭性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1be8234, createdName=sunyl07, createdTime=Sat Mar 21 01:10:05 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463982, encodeId=c613146398253, content=<a href='/topic/show?id=e58691932b6' target=_blank style='color:#2F92EE;'>#诺模图#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=91932, encryptionId=e58691932b6, topicName=诺模图)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13c36558142, createdName=zhangyxzsh, createdTime=Sat Mar 21 01:10:05 CST 2020, time=2020-03-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1040685, encodeId=d7181040685a3, content=前列腺癌相关研究，学习了，谢谢梅斯, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Thu Mar 19 13:10:05 CST 2020, time=2020-03-19, status=1, ipAttribution=)]
    2020-03-21 zhangyxzsh

    #诺模图#

    0

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    2020-03-19 misszhang

    前列腺癌相关研究，学习了，谢谢梅斯

    0

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