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JAMA Surgery:血管手术后患者死亡率与其术后肾功能明显相关

2015-12-24 MedSci MedSci原创

背景40%的患者手术后会出现急性肾损伤(AKI),且它会增加患者的全因死亡率。慢性肾脏疾病(CKD)是影响接受心血管手术患者的死亡率的重要因素。 目的该研究的目的是探究肾脏疾病和心血管疾病患者接受血管手术后长期死亡率之间的关系。方式一个单中心的队列研究,研究人员选取了2000年1月1日-2010年11月30日间在一家三甲教学医院接受血管手术的3646名住院患者。 为了探究患者接受血管手术后各种原因

背景
40%的患者手术后会出现急性肾损伤(AKI),且它会增加患者的全因死亡率。慢性肾脏疾病(CKD)是影响接受心血管手术患者的死亡率的重要因素。 


目的
该研究的目的是探究肾脏疾病和心血管疾病患者接受血管手术后长期死亡率之间的关系。

方式
一个单中心的队列研究,研究人员选取了2000年1月1日-2010年11月30日间在一家三甲教学医院接受血管手术的3646名住院患者。 为了探究患者接受血管手术后各种原因导致的死亡率,研究人员使用比例风险回归分析以评估民众的心血管疾病死亡率,同时与其他原因死亡率进行比较。通过调整患者的生命体征、手术类型和血红蛋白水平等变量后将肾脏疾病这一因素作为共同变量。研究人员于2014年1月31日-7月对患者进行随访以探究患者的生存率,并在2015年9月7日进行数据调查。研究人员关注的主要因素是患者围手术期AKI、CKD的发病率及患者的全因死亡率。
 
结果
结果表明,3646名接受血管手术的患者中,出现围手术期AKI的有1801名(49.4%),出现CKD的有496名(13.6%)。导致患者死亡的两大原因分别为心血管疾病(845/1577,占53.6%)和癌症(173/1577,占11.0%)。未患肾脏疾病、患AKI而无CKD、患CKD而无AKI、患有AKI和CKD的患者10年内心血管疾病死亡率分别约为17%、31%、30%、41%,调整后患者心血管疾病死亡的风险比及95% CI分别为2.07 [1.74-2.45]、2.01[1.46-2.78]、2.99 [2.37-3.78],且明显高于其他风险因素如年龄增加(增加1.03/年,1.02-1.04)、紧急手术(1.47; 1.27-1.71)、血红蛋白水平低于10 g/dL (1.39;1.14-1.69,相比血红蛋白水平高于12 g/dL)。

结论
病人接受血管手术后,相比出现CKD ,出现围手术期AKI与心血管疾病死亡率明显相关。研究人员人员认为,这有助于增强医务人员对术前后患者肾脏功能的关注并及时采取措施,以避免对患者的伤害。

原始出处:

Tezcan Ozrazgat-Baslanti,Paul Thottakkara,Salvatore Scali,Azra Bihorac,Charles Hobson,Cardiovascular-Specific Mortality and Kidney Disease in Patients Undergoing Vascular Surgery,Matthew Huber,JAMA Surgery,23,Dec,2015


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    2016-11-13 chg121
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    2016-08-02 yese
  5. [GetPortalCommentsPageByObjectIdResponse(id=2021513, encodeId=d2a62021513f6, content=<a href='/topic/show?id=31e8e9669d' target=_blank style='color:#2F92EE;'>#GER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7966, encryptionId=31e8e9669d, topicName=GER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Wed Jun 29 11:59:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877672, encodeId=5b0b18e76724d, content=<a href='/topic/show?id=b013169237f' target=_blank style='color:#2F92EE;'>#surgery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16923, encryptionId=b013169237f, topicName=surgery)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Sun Nov 13 21:59:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983467, encodeId=704a198346e63, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon Feb 22 08:59:00 CST 2016, time=2016-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1850567, encodeId=7cd2185056e17, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Tue Aug 02 05:59:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57059, encodeId=21715e05964, content=嗯,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG56963B8248B138520.jpg, createdBy=61841679327, createdName=路路, createdTime=Wed Jan 13 20:09:00 CST 2016, time=2016-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=56422, encodeId=8bbd56422c1, content=因却思婷, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9751678817, createdName=公孙乐, createdTime=Tue Jan 12 17:27:00 CST 2016, time=2016-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1971997, encodeId=fccd19e199719, content=<a href='/topic/show?id=0424896596c' target=_blank style='color:#2F92EE;'>#血管手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89659, encryptionId=0424896596c, topicName=血管手术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Sun Jun 12 22:59:00 CST 2016, time=2016-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47906, encodeId=7beb4e90654, content=cpb的肾损伤比起来不算什么,而且这与术前状况, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 10:51:00 CST 2015, time=2015-12-26, status=1, ipAttribution=)]
    2016-01-13 路路

    嗯,谢谢

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2021513, encodeId=d2a62021513f6, content=<a href='/topic/show?id=31e8e9669d' target=_blank style='color:#2F92EE;'>#GER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7966, encryptionId=31e8e9669d, topicName=GER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Wed Jun 29 11:59:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877672, encodeId=5b0b18e76724d, content=<a href='/topic/show?id=b013169237f' target=_blank style='color:#2F92EE;'>#surgery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16923, encryptionId=b013169237f, topicName=surgery)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Sun Nov 13 21:59:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983467, encodeId=704a198346e63, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon Feb 22 08:59:00 CST 2016, time=2016-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1850567, encodeId=7cd2185056e17, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Tue Aug 02 05:59:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57059, encodeId=21715e05964, content=嗯,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG56963B8248B138520.jpg, createdBy=61841679327, createdName=路路, createdTime=Wed Jan 13 20:09:00 CST 2016, time=2016-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=56422, encodeId=8bbd56422c1, content=因却思婷, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9751678817, createdName=公孙乐, createdTime=Tue Jan 12 17:27:00 CST 2016, time=2016-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1971997, encodeId=fccd19e199719, content=<a href='/topic/show?id=0424896596c' target=_blank style='color:#2F92EE;'>#血管手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89659, encryptionId=0424896596c, topicName=血管手术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Sun Jun 12 22:59:00 CST 2016, time=2016-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47906, encodeId=7beb4e90654, content=cpb的肾损伤比起来不算什么,而且这与术前状况, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 10:51:00 CST 2015, time=2015-12-26, status=1, ipAttribution=)]
    2016-01-12 公孙乐

    因却思婷

    0

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  8. [GetPortalCommentsPageByObjectIdResponse(id=2021513, encodeId=d2a62021513f6, content=<a href='/topic/show?id=31e8e9669d' target=_blank style='color:#2F92EE;'>#GER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7966, encryptionId=31e8e9669d, topicName=GER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Wed Jun 29 11:59:00 CST 2016, time=2016-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1877672, encodeId=5b0b18e76724d, content=<a href='/topic/show?id=b013169237f' target=_blank style='color:#2F92EE;'>#surgery#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16923, encryptionId=b013169237f, topicName=surgery)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7db99, createdName=chg121, createdTime=Sun Nov 13 21:59:00 CST 2016, time=2016-11-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1983467, encodeId=704a198346e63, content=<a href='/topic/show?id=628553048e3' target=_blank style='color:#2F92EE;'>#患者死亡#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53048, encryptionId=628553048e3, topicName=患者死亡)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Mon Feb 22 08:59:00 CST 2016, time=2016-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1850567, encodeId=7cd2185056e17, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Tue Aug 02 05:59:00 CST 2016, time=2016-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=57059, encodeId=21715e05964, content=嗯,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=112, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160113/IMG56963B8248B138520.jpg, createdBy=61841679327, createdName=路路, createdTime=Wed Jan 13 20:09:00 CST 2016, time=2016-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=56422, encodeId=8bbd56422c1, content=因却思婷, beContent=null, objectType=article, channel=null, level=null, likeNumber=136, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c9751678817, createdName=公孙乐, createdTime=Tue Jan 12 17:27:00 CST 2016, time=2016-01-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1971997, encodeId=fccd19e199719, content=<a href='/topic/show?id=0424896596c' target=_blank style='color:#2F92EE;'>#血管手术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89659, encryptionId=0424896596c, topicName=血管手术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Sun Jun 12 22:59:00 CST 2016, time=2016-06-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=47906, encodeId=7beb4e90654, content=cpb的肾损伤比起来不算什么,而且这与术前状况, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bc301610909, createdName=hixiaoluo, createdTime=Sat Dec 26 10:51:00 CST 2015, time=2015-12-26, status=1, ipAttribution=)]
    2015-12-26 hixiaoluo

    cpb的肾损伤比起来不算什么,而且这与术前状况

    0

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日常生活中及网友咨询过程中,有部分人(貌似也不少)把肾功能等同于性功能,生活中的朋友有时候问我是什么科的大夫,答“肾内科的”,然后他会对你一丝诡笑,貌似遇到了一位性爱专家,欣喜万分,然后想和你探讨如何提高性爱能力。在此向大家做个说明,现代医学的肾功能和性功能没有半毛钱的关系,肾内科大夫不是性功能专家。肾脏主要负责人体的排泄功能,人体代谢会产生上百种,甚至数百种废物,目前比较容易测定的是:尿素、肌酐

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在7月24日的西安会上,美国梅奥医学院的Win K. Shen教授,针对新型口服抗凝药(NOAC)的药物特征,以及如何个体化用药,进行了清晰详尽的讲解。 药物特征差异 目前,美国食品与药物管理局已经批准四种NOAC上市:达比加群(IIa因子抑制剂),以及阿哌沙班、依度沙班、利伐沙班(Xa因子抑制剂)。我国批准的NOAC包括达比加群、阿哌沙班及利伐沙班。 四种药物的半衰

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