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Science:过敏反应有防癌功效

2011-12-12 MedSci原创 MedSci原创

过敏是让很多人烦恼的事情,但它也有好的一面。英国伦敦大学国王学院等机构的研究人员在新一期美国《科学》(Science)杂志上发表了研究成果,研究显示,过敏反应可被机体组织用来防癌,因此如果在被过敏困扰的时候想想可能患癌风险下降了,也许心情就会变好一些。 他们观察了实验鼠上皮细胞在可能受到致癌因素伤害时的反应特征。上皮细胞是位于器官表面的细胞,它们经常面临致癌因素的威胁,比如皮肤外表的上皮细胞会受

过敏是让很多人烦恼的事情,但它也有好的一面。英国伦敦大学国王学院等机构的研究人员在新一期美国《科学》(Science)杂志上发表了研究成果,研究显示,过敏反应可被机体组织用来防癌,因此如果在被过敏困扰的时候想想可能患癌风险下降了,也许心情就会变好一些。

他们观察了实验鼠上皮细胞在可能受到致癌因素伤害时的反应特征。上皮细胞是位于器官表面的细胞,它们经常面临致癌因素的威胁,比如皮肤外表的上皮细胞会受到紫外线照射的影响,而肺部上皮细胞会受到吸烟的影响。

英国科研人员通过观察发现,上皮细胞在受到这些致癌因素威胁时,会释放出一种特殊分子,这种分子会激活周围的免疫细胞,让它们摧毁某个有可能癌变的上皮细胞。但与此同时,实验鼠身体其他部位的免疫组织也都被这种分子激活了,整个免疫系统开始释放出大量抗体,这种情形与机体过敏时发生的反应相同。

在过敏时,免疫系统的这种反应是为了清除进入体内的花粉等过敏原,而在抗癌“动机”的驱使下,免疫系统的上述反应是为了彻底清除那些由于威胁因素而产生、可能致癌的毒素,降低患癌症风险。(生物谷Bioon.com)

doi:10.1126/science.1211250
The Intraepithelial T Cell Response to NKG2D-Ligands Links Lymphoid Stress Surveillance to Atopy

Jessica Strid, Olga Sobolev, Biljana Zafirova, Bojan Polic, Adrian Hayday

Epithelial cells respond to physicochemical damage with up-regulation of major histocompatibility complex–like ligands that can activate the cytolytic potential of neighboring intraepithelial T cells by binding the activating receptor, NKG2D. The systemic implications of this lymphoid stress-surveillance response, however, are unknown. We found that antigens encountered at the same time as cutaneous epithelial stress induced strong primary and secondary systemic, T helper 2 (TH2)–associated atopic responses in mice. These responses required NKG2D-dependent communication between dysregulated epithelial cells and tissue-associated lymphoid cells. These data are germane to uncertainty over the afferent induction of TH2 responses and provide a molecular framework for considering atopy as an important component of the response to tissue damage and carcinogenesis.

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    2011-12-14 jichang
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    2011-12-14 jeanqiuqiu

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