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JAMA:1型糖尿病患者是否应该连续监测血糖水平

2017-01-29 MedSci MedSci原创

大多数1型糖尿病患者的血糖不能达到推荐的血糖控制目标。近期,一项发表在JAMA杂志上的研究评估了成人1型糖尿病患者每日多次胰岛素注射治疗进行连续葡萄糖监测的效果。研究为2014年2月24日至2016年6月1日期间在瑞典15个糖尿病门诊诊所进行的开放标签交叉随机临床试验,包括161名1型糖尿病患者并且血红蛋白A1c(HbA1c)至少7.5%(58 mmol/mol),使用每日多次胰岛素注射治疗。研究

大多数1型糖尿病患者的血糖不能达到推荐的血糖控制目标。


近期,一项发表在JAMA杂志上的研究评估了成人1型糖尿病患者每日多次胰岛素注射治疗进行连续葡萄糖监测的效果。

研究为2014年2月24日至2016年6月1日期间在瑞典15个糖尿病门诊诊所进行的开放标签交叉随机临床试验,包括161名1型糖尿病患者并且血红蛋白A1c(HbA1c)至少7.5%(58 mmol/mol),使用每日多次胰岛素注射治疗。

研究者们将参与者随机化分为使用连续葡萄糖监测系统或常规治疗接受治疗26周,通过17周的清除期分隔。

主要结果为2种处理方法的第26和69周之间HbA1c的差异。还研究了不良事件,包括严重低血糖
研究结果显示:161名随机化参与者中,平均年龄为43.7岁,45.3%为女性,平均HbA1c为8.6%(70 mmol/mol)。共有142名受试者参与两个治疗期并有随访数据。在连续葡萄糖监测期间平均HbA1c为7.92%(63mmol/mol),而在常规治疗期间平均HbA1c为8.35%(68mmol/mol)(平均差异,-0.43%[95%CI,-0.57%至-0.29%or -4.7 [-6.3至-3.1mmol/mol];P<0.001)。

在包括心理社会和各种血糖测量的19个次要终点中,6个符合具有统计显着性的分级测试标准,且与常规治疗相比,连续葡萄糖监测更有益。

常规治疗组中的5名患者和连续葡萄糖监测组中的1名患者具有严重的低血糖。在患者使用常规治疗的冲洗期间,7名患者具有严重的低血糖。

此项研究结果表明:在用每日多次胰岛素注射治疗的未充分控制的1型糖尿病的患者中,与常规治疗相比,使用连续葡萄糖监测治疗26周可以出现较低的HbA1c。尚需进一步的研究来评估临床结果和长期不良反应。

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    2017-02-04 ylzr123

    如果临床应用的话,会给患者带来希望的。渴望推广,好文点赞了!

    0

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    2017-02-02 天涯183

    最新研究进展。

    0

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