Blood：晚期皮肤T细胞淋巴瘤STAT-6调控基因的全基因转录组分析

2020-05-23 QQY MedSci原创

STAT-6是MF/SS肿瘤发生的主要因素，是一个有前景的治疗干预靶点。 STAT-6促进MF/SS恶性淋巴细胞的增殖和侵袭，同时逐步抑制抗肿瘤免疫反应。

信号转换器和转录激活因子6 (STAT-6)是IL-13和IL-4信号的关键上游调控因子，在Sezary综合征(SS)和蕈样肉芽肿(MF)的恶性淋巴细胞中组成性激活；SS和MF是皮肤T细胞淋巴瘤的最常见亚型。

通过结合全基因组表达谱和药物抑制STAT-6，研究人员发现，在MF/SS恶性淋巴瘤中，STAT-6调控的几条常见通路与细胞周期进展调控和基因组稳定性以及Th2细胞因子的产生相关。

通过来自皮肤MF肿瘤的体外皮肤外植体，以及来自SS患者血液的Sezary细胞，研究人员证实在MF/SS恶性淋巴细胞中，抑制STAT-6激活可下调细胞因子的产生，诱导细胞周期阻滞，进而抑制肿瘤细胞的增殖，但不会影响它们的存活。此外，研究人员还发现STAT-6可通过上调免疫抑制、趋化性和肿瘤基质重构相关基因的表达，在晚期MF的肿瘤微环境中促进肿瘤相关巨噬细胞的前肿瘤M2样表型。

因此，研究人员发现STAT-6是MF/SS发病和进展的主要因子，促进恶性淋巴细胞的增殖和侵袭，同时诱导抗肿瘤免疫反应的进行性抑制。总之，本研究结果为MF/SS的发病机制提供了新的见解，并为其治疗干预提供了新的潜在靶标。

原始出处：

Alyxzandria M Gaydosik，et al. Genome-wide transcriptome analysis of the STAT6-regulated genes in advanced-stage cutaneous T-cell lymphoma. Blood. May 21，2020.

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2021-02-13 anan

#调控基因#

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2020-11-26 marlenexl

#细胞淋巴瘤#

87 0
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2021-01-16 mjldent

#转录#

107 0
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2021-04-11 zhangyxzsh

#转录组分析#

108 0
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2020-05-25 aliceclz

#T细胞淋巴瘤#

87 0
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2020-05-25 marlenexl

#转录组#

91 0
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2020-05-25 12498f17m71暂无昵称

#皮肤T细胞淋巴瘤#

90 0
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2020-05-24 thm112988

好

143 0
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2020-05-24 njwbhuang

现在全很时髦啊

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