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小学生发SCI,中学生发新英格兰,叫咱们这些老脸往哪放?!这前浪太快了!

2020-07-14 BioWorld BioWorld

最近小学生的科研能力惊呆了所有人,全国青少年科技创新大赛的获奖作品引发广泛关注,详情:小学生就能研究基因和癌症关系,莫非这就是百年一遇的医学奇才?

最近小学生的科研能力惊呆了所有人,全国青少年科技创新大赛的获奖作品引发广泛关注,详情:小学生研究结直肠癌基因敲除获得全国青少年科技创新大赛三等奖? 你吐了?还是羡慕嫉妒恨?

类似的获奖项目还有很多,让一众硕士博士懵圈,实际上,有些小学生还发过SCI论文,中学生发过新英格兰医学期刊,这么一看,创新大赛是不是瞬间低调了起来?

2019年11月,国际顶级医学期刊 BMJ 旗下SCI期刊 Archives of Disease In Childhood 刊登了一篇题为:Screen of traditional soup broths with reported antipyretic activity towards the discovery of potential antimalarials 的研究论文。

该研究发现,一些羹汤中可能含有帮助抗击疟疾的有效成分,神奇的是,这篇论文的第一作者是一群小学生第一单位是伦敦伊甸园小学

虽然青蒿素等药物能够有效治疗疟疾,但目前,全球仍有一半的人处于感染疟疾的风险之中,据世界卫生组织WHO统计,2017年全球有2.19亿人感染疟疾,每年有近50万人死于疟疾。

疟原虫属中的几种疟原虫都会引起疟疾,但99%的疟疾死亡由恶性疟原虫导致,恶性疟原虫对抗疟疾药的耐药性越来越高,这使得抗疟新药的研发势在必行。

目前最有效的抗疟药青蒿素及其衍生物来自黄花蒿,黄花蒿是蒿属传统中草药,实际上,人们将青蒿作为中草药,治疗与疟疾有关的发热,已有2000多年的历史。

因此,研究人员想知道,还有其他具有抗疟疾特性的传统自然疗法吗

为了找出答案,研究人员筛选了来自欧洲、北非和中东国家的60种传统家庭羹汤,这些羹汤具有退烧的特性。

研究团队通过要求伦敦一所小学的不同种族背景的小学生带来他们家庭自制的羹汤,研究人员一共获得了60种不同的羹汤,其中有4种太稠或太油而无法过滤。

研究人员过滤了其余的56种汤。将经过过滤的提取物分别与恶性疟原虫共培育72小时,以观察这些汤的提取物是否会抑制疟原虫的生长。

具体来说,科学家们想看看这些提取物是否会抑制未性成熟的恶性疟原虫生长,以及是否会抑制它们的性成熟,因为疟原虫在性成熟后才能够感染蚊子,进而被传播至人体。

实验结果显示,有5种羹汤提取物对疟原虫生长的抑制超过50%,其中2种与常用抗疟疾药物二氢青蒿素效果相当。

还有另外4种羹汤提取物对疟原虫性成熟的抑制超过50%,这表明它们可能阻断疟疾的传播。

研究人员称,未来研究的重点是找出具体哪种成分具有最高的抗疟疾活性。

该研究的通讯作者,伦敦帝国理工学院 Jake Baum 教授认为,在反对循证医学呼声高涨之时,这项研究对于教育下一代如何发现新药具有重要意义,对于教会他们如何利用未开发的资源对抗全球性疾病具有重要作用。

其实早在2011年,英国小学生就发过3分以上的SCI文章了!

2011年英国皇家学会主办的《生物学快报》(Biology Letters, IF=3.521)标题为“Blackawton bees”的文章,单看文章的内容可能只是一项普通的生物学研究,只能算海量 SCI 文章中的一篇,可是让人惊叹不已的是文章的作者竟然是英国 Blackawton 小学的一群小学生。

你以为小学生发SCI论文就完了?

当看到这篇 NEJM 论文,我不得不感慨,自己还是Too Young

2020年3月8日,国际四大医学期刊之首NEJM 杂志发表了题为:Infections Associated with Resterilized Pacemakers and Defibrillators 的研究论文。

该研究的最终结论是,使用经过消毒的起搏器和除颤器是安全的,这将有助于挽救许多人的生命

论文第一作者 Thomas F. Khairy 是一个15岁的中学生,直接打破了 NEJM 论文第一作者的年龄记录,据透露,第一作者 Thomas F. Khairy 12岁的时候就加入了该研究。

 

第一作者手持起搏器(左手)和除颤器(右手)

这或许是一个天才少年的故事,不过,该研究的领导者、论文的通讯作者 Paul Khairy 正是第一作者 Thomas F. Khairy 的父亲

原始出处:

Children of Eden Primary School, Straschil U, Witmer K, Delves MJ, Marks SD, Baum J. Screen of traditional soup broths with reported antipyretic activity towards the discovery of potential antimalarials. Arch Dis Child. 2019 Dec;104(12):1138-1142. doi: 10.1136/archdischild-2019-317590.
 
Khairy TF, Lupien MA, Nava S, Baez FV, Ovalle FS, Ochoa NEL, Mendoza GS, Carrazco CA, Villemaire C, Cartier R, Roy D, Talajic M, Dubuc M, Thibault B, Guerra PG, Rivard L, Dyrda K, Mondésert B, Tadros R, Cadrin-Tourigny J, Macle L, Khairy P. Infections Associated with Resterilized Pacemakers and Defibrillators. N Engl J Med. 2020 May 7;382(19):1823-1831. doi: 10.1056/NEJMoa1813876.
 
Blackawton PS, Airzee S, Allen A, Baker S, Berrow A, Blair C, Churchill M, Coles J, Cumming RF, Fraquelli L, Hackford C, Hinton Mellor A, Hutchcroft M, Ireland B, Jewsbury D, Littlejohns A, Littlejohns GM, Lotto M, McKeown J, O'Toole A, Richards H, Robbins-Davey L, Roblyn S, Rodwell-Lynn H, Schenck D, Springer J, Wishy A, Rodwell-Lynn T, Strudwick D, Lotto RB. Blackawton bees. Biol Lett. 2011 Apr 23;7(2):168-72. doi: 10.1098/rsbl.2010.1056.

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    2021-08-30 gritgrit

    叹服

    0

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  4. [GetPortalCommentsPageByObjectIdResponse(id=1012826, encodeId=fd1f1012826da, content=叹服, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f0001540535, createdName=gritgrit, createdTime=Mon Aug 30 13:34:54 CST 2021, time=2021-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748695, encodeId=78531e4869564, content=<a href='/topic/show?id=52d15861349' target=_blank style='color:#2F92EE;'>#新英格兰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58613, encryptionId=52d15861349, topicName=新英格兰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db3e36178621, createdName=shalley78, createdTime=Fri Nov 06 04:27:31 CST 2020, time=2020-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907342, encodeId=adf3190e34281, content=<a href='/topic/show?id=531f4e00639' target=_blank style='color:#2F92EE;'>#小学生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47006, encryptionId=531f4e00639, topicName=小学生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c982214, createdName=tomyang86, createdTime=Mon Sep 21 09:27:31 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894686, encodeId=028d894686a8, content=咱得多不要脸才够呐, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f8e5429314, createdName=ms1000001521114643, createdTime=Tue Oct 27 05:44:49 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881684, encodeId=ca1c881684f6, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Tue Sep 01 08:21:36 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810980, encodeId=a9908109801c, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 16:12:13 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807478, encodeId=5c9080e47888, content=学二代啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e462271105, createdName=121a58b4m57暂无昵称, createdTime=Tue Aug 11 14:57:58 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804796, encodeId=be03804e96a9, content=什么时候出了大于3再来发表吧,JCR的SCI没有什么水平, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4052490659, createdName=12479e68m72暂无昵称, createdTime=Mon Jul 27 21:29:04 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802767, encodeId=c535802e6726, content=赢在起跑线上的人, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200714/5f6d05eded1142949aed85de39a644c5/a6bde2cdc91a4246a62fd37e1bfe0674.jpg, createdBy=c5d35400023, createdName=ms6000001102576159, createdTime=Tue Jul 14 15:35:50 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802750, encodeId=8dbe802e50bf, content=无话可说, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07dd5400340, createdName=科研小白要前进, createdTime=Tue Jul 14 12:26:41 CST 2020, time=2020-07-14, status=1, ipAttribution=)]
    2020-10-27 ms1000001521114643

    咱得多不要脸才够呐

    0

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    2020-09-01 14818eb4m67暂无昵称

    学习

    0

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    2020-08-19 ms5000000741733160

    很好

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1012826, encodeId=fd1f1012826da, content=叹服, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f0001540535, createdName=gritgrit, createdTime=Mon Aug 30 13:34:54 CST 2021, time=2021-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1748695, encodeId=78531e4869564, content=<a href='/topic/show?id=52d15861349' target=_blank style='color:#2F92EE;'>#新英格兰#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58613, encryptionId=52d15861349, topicName=新英格兰)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=db3e36178621, createdName=shalley78, createdTime=Fri Nov 06 04:27:31 CST 2020, time=2020-11-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1907342, encodeId=adf3190e34281, content=<a href='/topic/show?id=531f4e00639' target=_blank style='color:#2F92EE;'>#小学生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=47006, encryptionId=531f4e00639, topicName=小学生)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c982214, createdName=tomyang86, createdTime=Mon Sep 21 09:27:31 CST 2020, time=2020-09-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=894686, encodeId=028d894686a8, content=咱得多不要脸才够呐, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0f8e5429314, createdName=ms1000001521114643, createdTime=Tue Oct 27 05:44:49 CST 2020, time=2020-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=881684, encodeId=ca1c881684f6, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=64245268311, createdName=14818eb4m67暂无昵称, createdTime=Tue Sep 01 08:21:36 CST 2020, time=2020-09-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=810980, encodeId=a9908109801c, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=25e55411955, createdName=ms5000000741733160, createdTime=Wed Aug 19 16:12:13 CST 2020, time=2020-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=807478, encodeId=5c9080e47888, content=学二代啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7e462271105, createdName=121a58b4m57暂无昵称, createdTime=Tue Aug 11 14:57:58 CST 2020, time=2020-08-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=804796, encodeId=be03804e96a9, content=什么时候出了大于3再来发表吧,JCR的SCI没有什么水平, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d4052490659, createdName=12479e68m72暂无昵称, createdTime=Mon Jul 27 21:29:04 CST 2020, time=2020-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802767, encodeId=c535802e6726, content=赢在起跑线上的人, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200714/5f6d05eded1142949aed85de39a644c5/a6bde2cdc91a4246a62fd37e1bfe0674.jpg, createdBy=c5d35400023, createdName=ms6000001102576159, createdTime=Tue Jul 14 15:35:50 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802750, encodeId=8dbe802e50bf, content=无话可说, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07dd5400340, createdName=科研小白要前进, createdTime=Tue Jul 14 12:26:41 CST 2020, time=2020-07-14, status=1, ipAttribution=)]
    2020-08-11 121a58b4m57暂无昵称

    学二代啊

    0

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    2020-07-27 12479e68m72暂无昵称

    什么时候出了大于3再来发表吧,JCR的SCI没有什么水平

    0

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    2020-07-14 ms6000001102576159

    赢在起跑线上的人

    0

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    2020-07-14 科研小白要前进

    无话可说

    0

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