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Heart:主动脉瓣狭窄男性和女性患者超声心动图上主动脉瓣钙化和预后如何?

2017-07-12 xing.T MedSci原创

由此可见,超声心动图测得的AVC得分在AS中具有性别特异性的特点。中度/重度AVC与男性和女性更高的心血管发病率相关,并且与男性的较高的全因死亡率相关。

通过超声心动图得到的主动脉瓣钙化(AVC)危险因素的性别差异在主动脉狭窄(AS)的前瞻性研究中尚未报道。近日,在心脏病领域权威杂志Heart上发表了一篇研究文章,研究人员采用预后验证视觉评分对辛伐他汀联合依折麦布治疗AS研究中的1725例男性和女性无症状AS患者进行评估分为无/轻度或中度/重度AVC。研究人员采用能量损失指数(ELI)通过主动脉根部压力恢复情况来评估其严重程度。研究人员发现在研究之初相比于女性,更多的男性有中/重度AVC,虽然ELI评估的严重AS较少(P<0.01)。在基线时,中度/重度AVC与男性和女性低主动脉顺应性和更严重的AS独立相关,仅在男性中增加高敏C反应蛋白(P<0.01)。Cox的回归分析中,基线中度/重度AVC与女性主要心血管事件风险率增加2.5倍(95%可信区间为1.64-3.80)以及男性风险率增加2.2倍(95%可信区间为1.54-.17)相关(P<0.001),调整年龄、高血压、研究治疗、主动脉顺应性、左心室(LV)质量和收缩功能、AS严重程度和hs-CRP。基线中度/重度AVC也预测了1.8倍较高的男性风险率(95%可信区间为1.04-3.06

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createdBy=8d6717964407, createdName=respect, createdTime=Fri Jul 14 05:46:00 CST 2017, time=2017-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=221468, encodeId=b9382214685e, content=学习了受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Wed Jul 12 17:48:57 CST 2017, time=2017-07-12, status=1, ipAttribution=)]
    2017-07-19 lou.minghong

    学习了谢谢分享!

    0

  5. 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    2017-07-14 zhaojie88
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  8. 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    2017-07-14 slcumt
  9. 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    2017-07-12 131****1460

    学习了受益匪浅。

    0

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