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J Mech Behav Biomed Mater:将HA掺入多孔钛中以形成Ti-HA生物复合泡沫

2019-10-29 不详 网络

钛泡沫材料是先进的材料,具有巨大的生物医学应用潜力,因为它们可以通过提供相互连接的多孔通道促进骨长入,细胞迁移和附着,从而允许骨形成细胞穿透并为它们提供锚固位点。但是,Ti是一种生物惰性材料,因此只能在多孔植入物和周围组织之间实现机械整合,而不能实现化学整合。在这项工作中,将生物活性材料(Hydroxyapatite,HA)的颗粒与钛粉混合,并通过与空间支架结合使用金属注射成型(MIM)来生产Ti

钛泡沫材料是先进的材料,具有巨大的生物医学应用潜力,因为它们可以通过提供相互连接的多孔通道促进骨长入,细胞迁移和附着,从而允许骨形成细胞穿透并为它们提供锚固位点。但是,Ti是一种生物惰性材料,因此只能在多孔植入物和周围组织之间实现机械整合,而不能实现化学整合。

在这项工作中,将生物活性材料(Hydroxyapatite,HA)的颗粒与钛粉混合,并通过与空间支架结合使用金属注射成型(MIM)来生产Ti泡沫。这将产生掺有HA的钛泡沫,从而可能对周围组织的植入物产生更有利的骨骼反应,并改善Ti泡沫的骨整合。为了做到这一点,样品需要表现出足够的机械和生物相容性,并对生产的泡沫的机械性能和体外生物学反应进行评估。

结果显示,将高含量的HA掺入Ti泡沫中会引起结构脆性,并降低Ti泡沫的承载能力,因为Ti和HA之间的化学相互作用导致陶瓷相变弱。但是,发现添加少量的HA(约2vol%)会使Ti泡沫的屈服强度从31.6 MPa增加到50.9 MPa,增加了61%。为了研究泡沫在生物医学中的适用性,还进行了生物学测试。发现添加和不添加HA的Ti泡沫(添加量为2vol%)都支持钙和胶原蛋白的生产,并且具有良好的生物相容性,添加和不添加HA的样品之间没有显着差异。

原始出处:

Shbeh M, Wally ZJ, et al., Incorporation of HA into porous titanium to form Ti-HA biocomposite foams. J Mech Behav Biomed Mater. 2019 Aug;96:193-203. doi: 10.1016/j.jmbbm.2019.04.043. Epub 2019 Apr 25.

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    2020-01-28 30397613
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    2020-02-12 sunylz
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    2019-10-31 qjddjq
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