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ANN SURG:遗传性弥漫性胃癌全胃切除术单中心经验

2017-11-21 MedSci MedSci原创

遗传性弥漫性胃癌(HDGC)主要由CDH1细胞突变引起,一生患胃癌风险高达70%,需要进行预防性全胃切除。ANN SURG近期发表了一篇文章,研究遗传性弥漫性胃癌患者接受全胃切除后的结果。

遗传性弥漫性胃癌(HDGC)主要由CDH1细胞突变引起,一生患胃癌风险高达70%,需要进行预防性全胃切除。ANN SURG近期发表了一篇文章,研究遗传性弥漫性胃癌患者接受全胃切除后的结果。

作者在2005年到2015年接受治疗的患者中鉴别出41例CDH1突变的胃癌患者。41例患者均接受全胃切除术,平均年龄47岁。14例男性,27例女性,25例开放手术,16例微创手术。平均住院时间为7天。11例患者出现需要治疗干预的并发症,1例围手术期死亡。35例患者在组织中发现一处或多处粘膜内印戒细胞癌。平均随访时间16个月,平均体重降低4.7公斤。术后6-12个月,体重趋于稳定。40%的患者认为最后的结果与预期相似,45%的患者认为最后的结果优于预期。病人报告的结果与其他接受全胃切除术的患者结果相似。

所有CDH1突变均应考虑全胃切除,因为其为浸润弥漫型胃癌且缺少可靠的预后选择。大部分患者全胃切除术后出现体重下降,术后6-12个月体重稳定,且病人报告的结果与术前预期相符或优于预期。切除后没有患者出现胃癌复发。

原始出处:
Strong Vivian E,Gholami Sepideh,et al.Total Gastrectomy for Hereditary Diffuse Gastric Cancer at a Single Center:Postsurgical Outcomes in 41 Patients.ANN SURG.December 2017 doi:10.1097/SLA.0000000000002030

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    2017-11-25 大爰

    学习了谢谢分享!!

    0

  5. 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    2017-11-23 bshuang
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time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263100, encodeId=395e263100c1, content=继续关注. , beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Nov 21 12:52:07 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263099, encodeId=35dc26309926, content=继续学习. , beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Nov 21 12:52:04 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263060, encodeId=b45d26306070, content=预防性全胃切除预防遗传性弥漫性胃癌, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Tue Nov 21 10:12:02 CST 2017, time=2017-11-21, status=1, ipAttribution=)]
    2017-11-21 doctorJiangchao

    谢谢分享.

    0

  8. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Nov 21 12:52:04 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263060, encodeId=b45d26306070, content=预防性全胃切除预防遗传性弥漫性胃癌, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Tue Nov 21 10:12:02 CST 2017, time=2017-11-21, status=1, ipAttribution=)]
    2017-11-21 doctorJiangchao

    继续关注.

    0

  9. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Nov 21 12:52:04 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263060, encodeId=b45d26306070, content=预防性全胃切除预防遗传性弥漫性胃癌, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Tue Nov 21 10:12:02 CST 2017, time=2017-11-21, status=1, ipAttribution=)]
    2017-11-21 doctorJiangchao

    继续学习.

    0

  10. 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content=<a href='/topic/show?id=324183166ad' target=_blank style='color:#2F92EE;'>#胃切除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83166, encryptionId=324183166ad, topicName=胃切除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e3cc11160823, createdName=bshuang, createdTime=Thu Nov 23 00:12:00 CST 2017, time=2017-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263101, encodeId=f9d926310171, content=谢谢分享. , beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Nov 21 12:52:15 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263100, encodeId=395e263100c1, content=继续关注. , beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Nov 21 12:52:07 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263099, encodeId=35dc26309926, content=继续学习. , beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Tue Nov 21 12:52:04 CST 2017, time=2017-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=263060, encodeId=b45d26306070, content=预防性全胃切除预防遗传性弥漫性胃癌, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzcjoLTEEgkSSQ8pVIiaf4a4INaoMLBV16QEk3dvvBRpicwIwmDGv0jePErJ4aE9ibVBDPtkialQLT9Bs/0, createdBy=04811949400, createdName=邓启付, createdTime=Tue Nov 21 10:12:02 CST 2017, time=2017-11-21, status=1, ipAttribution=)]
    2017-11-21 邓启付

    预防性全胃切除预防遗传性弥漫性胃癌

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