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Radiology:定量CT和肺功能在慢性阻塞性肺疾病中肺气肿性和非肺气肿性气体陷闭的价值

2018-02-24 shaosai MedSci原创

本研究旨在通过分类肺气肿性和非肺气肿性气体陷闭验证慢性阻塞性肺疾病(COPD)患者的CT亚型,并试图利用临床和肺功能数据预测并分级肺气肿气体阻塞,研究人员将结果发表在Radiology上。

本研究旨在通过分类肺气肿性和非肺气肿性气体陷闭验证慢性阻塞性肺疾病(COPD)患者的CT亚型,并试图利用临床和肺功能数据预测并分级肺气肿气体阻塞,研究人员将结果发表在Radiology上。

本研究共纳入了202例患者(男性159例,平均年龄70岁),并行CT扫描及肺功能检查。CT扫描均在吸气末和呼气末进行,并利用2种软件进行分析。利用吸气末及呼气末CT阈值差异得到气体陷闭(吸气末和呼气末CT值少于-950HU的区域与呼气末CT值少于-856HU的区域比值),并利用配准分析进行两组比较。跟军肺气肿对总体气体陷闭的贡献,基于人体测量学和肺功能数据建立Logistic回归模型进行训练和验证来对COPD患者进行分类。

结果为,通过呼气末和吸气末CT密度阈值差异得到的气体陷闭与配准得到的气体陷闭具有高度相关性(r = 0.99)。根据CT亚型对患者分为4组:经典肺气肿性气体陷闭、功能性气体陷闭、混合型重度气体陷闭和混合型轻度气体陷闭。预测模型包括1秒用力呼气体积/肺活量、1秒用力呼气量百分比、二氧化碳扩散力百分比、和体重指数,并作为CT上肺气肿回归量。

本研究表明,肺气肿和肺气肿性气体陷闭的相对贡献量可通过CT呼气末和吸气末密度阈值差异精确评价,肺气肿的CT评估等级可通过肺功能和身体指数进行预测并应用于临床

原始出处:


10.1148/radiol.2017171519

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1640607, encodeId=7a17164060e94, content=<a href='/topic/show?id=183d459e8b1' target=_blank style='color:#2F92EE;'>#定量CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45978, encryptionId=183d459e8b1, topicName=定量CT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e60322689360, createdName=ms7474195563676018, createdTime=Thu Jan 03 14:32:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291517, encodeId=ff4829151e1d, content=呵呵.我学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Wed Feb 28 00:53:26 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696802, encodeId=8bcb1696802aa, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Fri Jul 27 17:32:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290785, encodeId=c19a290e85c0, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Feb 25 09:56:58 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290730, encodeId=4dee290e304f, content=好吧.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Sun Feb 25 07:47:50 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290456, encodeId=837e29045662, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Sat Feb 24 08:47:58 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290364, encodeId=55a82903641f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat Feb 24 06:25:36 CST 2018, time=2018-02-24, status=1, ipAttribution=)]
    2018-02-28 Drhzm308

    呵呵.我学习了

    0

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    2018-07-27 tomyang96
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    2018-02-25 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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    2018-02-25 Drhzm308

    好吧.学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1640607, encodeId=7a17164060e94, content=<a href='/topic/show?id=183d459e8b1' target=_blank style='color:#2F92EE;'>#定量CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45978, encryptionId=183d459e8b1, topicName=定量CT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e60322689360, createdName=ms7474195563676018, createdTime=Thu Jan 03 14:32:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291517, encodeId=ff4829151e1d, content=呵呵.我学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Wed Feb 28 00:53:26 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696802, encodeId=8bcb1696802aa, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Fri Jul 27 17:32:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290785, encodeId=c19a290e85c0, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Feb 25 09:56:58 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290730, encodeId=4dee290e304f, content=好吧.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Sun Feb 25 07:47:50 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290456, encodeId=837e29045662, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Sat Feb 24 08:47:58 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290364, encodeId=55a82903641f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat Feb 24 06:25:36 CST 2018, time=2018-02-24, status=1, ipAttribution=)]
    2018-02-24 139****5926

    好好文章学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1640607, encodeId=7a17164060e94, content=<a href='/topic/show?id=183d459e8b1' target=_blank style='color:#2F92EE;'>#定量CT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45978, encryptionId=183d459e8b1, topicName=定量CT)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e60322689360, createdName=ms7474195563676018, createdTime=Thu Jan 03 14:32:00 CST 2019, time=2019-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=291517, encodeId=ff4829151e1d, content=呵呵.我学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Wed Feb 28 00:53:26 CST 2018, time=2018-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696802, encodeId=8bcb1696802aa, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, createdName=tomyang96, createdTime=Fri Jul 27 17:32:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290785, encodeId=c19a290e85c0, content=学习了.涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Sun Feb 25 09:56:58 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290730, encodeId=4dee290e304f, content=好吧.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Sun Feb 25 07:47:50 CST 2018, time=2018-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290456, encodeId=837e29045662, content=好好文章学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K1RUfOKQohib4bXhDtxVgOA9VcKY1LUZkCOmr0v3WupxANz2ibibNHkdevtSruvrhyI29IjXdtvUV48/0, createdBy=6ff82057534, createdName=139****5926, createdTime=Sat Feb 24 08:47:58 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290364, encodeId=55a82903641f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=90, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat Feb 24 06:25:36 CST 2018, time=2018-02-24, status=1, ipAttribution=)]
    2018-02-24 121832a9m88暂无昵称

    学习了

    0

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