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Br J Surg:应对65岁女性进行腹主动脉瘤筛查

2016-06-28 phylis 译 MedSci原创

背景:四个65-80岁的男性随机对照试验表明:通过超声筛查,动脉瘤相关的死亡率可减少40%。腹主动脉瘤(AAA)的患病率是1.0%或更高时,超声检查是有可观的经济效益的。但女性患者AAA发病率小于1.0%。本研究的目的是超声扫描确定女性3.0 cm或更大AAA的发生率,这类人群中AAA相关危险因素,是否可以确定为1%或更高的AAA发生率的高危患者。方法:收集英国私人心血管检查的50000名女性的人

背景:四个65-80岁的男性随机对照试验表明:通过超声筛查,动脉瘤相关的死亡率可减少40%。腹主动脉瘤(AAA)的患病率是1.0%或更高时,超声检查是有可观的经济效益的。但女性患者AAA发病率小于1.0%。本研究的目的是超声扫描确定女性3.0 cm或更大AAA的发生率,这类人群中AAA相关危险因素,是否可以确定为1%或更高的AAA发生率的高危患者。

方法:收集英国私人心血管检查的50000名女性的人口统计学数据和风险因素。测试包括超声筛查AAA,踝 : 肱压指数(ABPI)、颈动脉彩超对颈动脉粥样硬化的检查、心电图检查心房颤动的发生。

结果:从50 000女性中筛查出82例女性存在AAA; 66岁以下的患者,动脉瘤较罕见(7/24 499)。在66-85岁年龄组25 170女性中有72例女性存在腹主动脉瘤(0·29%)。单因素分析表明,卒中/短暂性脑缺血发作史(TIA)、高血压、吸烟、房颤、ABPI小于0.9,50以上的颈内动脉狭窄与AAA发病率增加相关(P<0  ·001)。多变量Logistic回归分析,年龄76岁以上,脑卒中/TIA、高血压和吸烟为AAA的独立预测因子。ROC曲线的AUC为0.711(95% 0.649-0.772),可确定2235名女性22例女性存在AAA(患病率0.98%)。模型中加入ABPI,房颤,颈动脉狭窄后,AUC提高到0.775(0.724到0.826)。该模型可以确定3701名女性58例有AAA(患病率1.57%)。

结论:该报告提示对65岁以上女性应进行AAA的筛查。

原始出处:

Chabok M, Nicolaides A, et al. Risk factors associated with increased prevalence of abdominal aortic aneurysm in women. Br J Surg. 2016 Jun 22.


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    2016-09-16 ylzr123

    赞一个!好文章拜读了,认真学习了。

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  2. [GetPortalCommentsPageByObjectIdResponse(id=128539, encodeId=09e4128539e7, content=赞一个!好文章拜读了,认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Fri Sep 16 10:03:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=119380, encodeId=15a211938049, content=好文章,百姓也能从中学到好多医学知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=133, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Sep 10 15:38:00 CST 2016, time=2016-09-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415055, encodeId=cfd5141505567, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Thu Jun 30 13:28:00 CST 2016, time=2016-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428999, encodeId=da541428999fb, content=<a href='/topic/show?id=ee192321560' target=_blank style='color:#2F92EE;'>#主动脉瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23215, encryptionId=ee192321560, topicName=主动脉瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95e34160730, createdName=fengting4, createdTime=Thu Jun 30 13:28:00 CST 2016, time=2016-06-30, status=1, ipAttribution=)]
    2016-09-10 1e10c84am36(暂无匿称)

    好文章,百姓也能从中学到好多医学知识

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