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Eur J Vasc Endovasc Surg:肢体缺血患者术前贫血会导致其更高的死亡风险

2016-05-29 Seven L MedSci原创

近期研究结果表明,肢体缺血患者在接受治疗前存在贫血,那么其术后有更大的短期和长期风险。不管进行血管重建术的类型,还是独立的其他危险因素,这种风险的增加均是存在的。该研究纳入了2005至2013之间的403例患者(平均年龄73岁;73%为男性)接受了血管内(n = 212)或开放手术(n = 191)治疗严重肢体缺血(CLI)的患者。获取患者治疗前血红蛋白水平,以评估术前是否存在贫血(男性:小于13

近期研究结果表明,肢体缺血患者在接受治疗前存在贫血,那么其术后有更大的短期和长期风险。不管进行血管重建术的类型,还是独立的其他危险因素,这种风险的增加均是存在的。

该研究纳入了2005至2013之间的403例患者(平均年龄73岁;73%为男性)接受了血管内(n = 212)或开放手术(n = 191)治疗严重肢体缺血(CLI)的患者。获取患者治疗前血红蛋白水平,以评估术前是否存在贫血(男性:小于13 g/dL;女性:小于12 g/dL)。平均随访30个月,以短期和长期存活作为研究的主要终点。

数据显示,术前贫血占75%,院内或治疗30天内的死亡率为8%,两组之间无差异(8.5% vs. 7.3%)。当血红蛋白为10 g/dL时,有最佳的短期生存预测效果,接受者操作特征曲线分析其判别能力为0.665(95% CI,0.6-0.8)。术前血红蛋白水平低于10 g/dL的占22%,短期死亡率在这类患者中明显更高(17.7% vs. 5.1%;aOR=3.9; 95% CI, 1.8-8.4)。

对391名有可用随访数据的患者分析后发现,1年和5年生存率分别为77%和45%,不同手术类型间不存在差异。术前血红蛋白水平低于10 g/dL的患者无论是1年生存(55% vs. 83%)还是5年生存(21% vs. 53%;aHR=2.5; 95% CI, 1.8-3.4)均显著更低。

血管内治疗组患者的分析显示,无术前是否贫血,患者短期生存率无显著差异(P = .363),但是较低血红蛋白水平患者的长期生存率较差(P < .001)。在开放性手术组中,术前贫血患者的短期和长期死亡率均更高(两者P均 < .001 )。

“术前贫血被确定为肢体缺血患者短期和远期死亡率的一个危险因素,而不管其他风险因素和血管重建技术的类型,”研究人员写道,“建议术前对患者的贫血进行治疗, 但是该类患者术前贫血的最佳管理仍不清楚。”

原始出处:

Velescu A, et al. Anemia Increases Mortality After Open or Endovascular Treatment in Patients with Critical Limb Ischemia: A Retrospective Analysis.Eur J Vasc Endovasc Surg. 2016;doi:10.1016/j.ejvs.2015.12.006.

Preoperative anemia increases mortality risk after surgery for CLI.Healio.May 27, 2016

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    2017-04-06 quxin068
  2. [GetPortalCommentsPageByObjectIdResponse(id=1938553, encodeId=ffa919385538e, content=<a href='/topic/show?id=1c292818fd' target=_blank style='color:#2F92EE;'>#ASC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2818, encryptionId=1c292818fd, topicName=ASC)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Thu Apr 06 07:48:00 CST 2017, time=2017-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129434, encodeId=92a312943483, content=不错哦,会学到很多,喜欢梅斯医学文章, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sat Sep 17 11:47:00 CST 2016, time=2016-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=108434, encodeId=d4d010843416, content=好文,值得学习,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Wed Aug 31 13:31:00 CST 2016, time=2016-08-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1970154, encodeId=40fb19e0154fb, content=<a href='/topic/show?id=1efe6102ef4' target=_blank style='color:#2F92EE;'>#术前贫血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61027, encryptionId=1efe6102ef4, topicName=术前贫血)], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160723/IMG57937A3BB59F33185.jpg, createdBy=7642322, createdName=手留余香, createdTime=Thu Dec 01 06:48:00 CST 2016, time=2016-12-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1255563, encodeId=2081125556362, content=<a href='/topic/show?id=587f6339050' target=_blank style='color:#2F92EE;'>#死亡风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63390, encryptionId=587f6339050, topicName=死亡风险)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=quxin068, createdTime=Tue May 31 08:48:00 CST 2016, time=2016-05-31, status=1, ipAttribution=)]
    2016-09-17 1e10c84am36(暂无匿称)

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    0

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    2016-08-31 ylzr123

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