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JACC:亚洲房颤患者卒中风险增加的年龄阈值需要改变

2015-09-15 崔倩 译 MedSci原创

亚洲最近的研究表明,对于房颤(AF),“低风险”的风险充血性心脏衰竭,高血压,年龄≥75岁,糖尿病,之前发生过中风或短暂性缺血发作,血管疾病,65到74岁,女性(CHA2DS2-VASC)评分为0(男性)或1(对于女性)的患者缺血性中风的可能比非亚洲人要高。 本研究假设在CHA2DS2-VASC系统中用于开始口服抗凝剂的(OACS)使用的年龄阈值(65岁)在台湾的AF患者可能比非亚洲人要低。研究人

亚洲最近的研究表明,对于“低风险”的充血性心力衰竭、高血压、年龄≥75岁、糖尿病、之前发生过中风或短暂性缺血发作、血管疾病、65到74岁、女性(CHA2DS2-VASC)评分为0(男性)或1(对于女性)的亚洲房颤(AF)患者的缺血性中风的可能比非亚洲人要高。 本研究假设在CHA2DS2-VASC系统中用于开始口服抗凝剂的(OACS)使用的年龄阈值(65岁)在台湾的AF患者可能比非亚洲人要低。

研究人员使用台湾国民健康保险研究资料库来研究186570例不使用抗凝药物的房颤患者。有9416名男性CHA2DS2-VASC得分为0,6390位女性CHA2DS2-VASC得分为1。他们的缺血性中风的风险在年龄的基础上分层进行分析。

男性(0分)和女性(1分)缺血性中风的年度的风险分别为1.15%和1.12%,持续从年轻群体增长到老年群体,并且>50岁的患者卒中风险明显增加。在50岁的分界线上,患者可进一步分层为两个不同卒中风险的亚组(>50岁:1.78%/年;vs <50岁:0.53%/年)。这一现象在AF男性(分别为1.95%/年 vs 0.46%/年)和AF女性(1.58%/年对0.64%/年,分别)中是一致的。在一个亚组分析中,50?54岁的AF男性和女性的缺血性中风的年度风险分别为1.47%和1.07%。

对于50至64岁的台湾患者,年度卒中风险为1.78%,这可能会超过OAC用于预防中风的年龄阈值。<50岁的房颤患者缺血性中风的年度风险为0.53%,这是真正的低风险,OACS可以忽略。对于亚洲房颤患者,是否重新设定年龄阈值至50岁来改善目前的临床危险分层,值得进一步研究。

原始出处:

Tze-Fan Chao,Kang-Ling Wang,Chia-Jen Liu,et al.Age Threshold for Increased Stroke Risk Among Patients With Atrial Fibrillation,JACC,2015.9.15

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    2016-01-23 hbwxf
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    2015-09-17 qjddjq
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  6. [GetPortalCommentsPageByObjectIdResponse(id=1853412, encodeId=5ad6185341218, content=<a href='/topic/show?id=48351020537' target=_blank style='color:#2F92EE;'>#JACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10205, encryptionId=48351020537, topicName=JACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=55ce62, createdName=hbwxf, createdTime=Sat Jan 23 14:43:00 CST 2016, time=2016-01-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281193, encodeId=2c11128119323, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Thu Sep 17 02:43:00 CST 2015, time=2015-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1325105, encodeId=fea7132510590, content=<a href='/topic/show?id=96c71804b7' target=_blank style='color:#2F92EE;'>#ACC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1804, encryptionId=96c71804b7, topicName=ACC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1e452500029, createdName=12498568m50暂无昵称, createdTime=Thu Sep 17 02:43:00 CST 2015, time=2015-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553585, encodeId=71c21553585c1, content=<a href='/topic/show?id=839e9e33475' target=_blank style='color:#2F92EE;'>#阈值#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97334, encryptionId=839e9e33475, topicName=阈值)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2f4f14387940, createdName=qjddjq, createdTime=Thu Sep 17 02:43:00 CST 2015, time=2015-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1614273, encodeId=0b4516142e31e, content=<a href='/topic/show?id=64f95426122' target=_blank style='color:#2F92EE;'>#房颤患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54261, encryptionId=64f95426122, topicName=房颤患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=937e19519012, createdName=hittouch, createdTime=Thu Sep 17 02:43:00 CST 2015, time=2015-09-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=36939, encodeId=01bb36939e2, content=这其实背后还有一个原因,亚洲人的卒中,糖尿病,高血压,明显都偏年轻,那么到底是什么原因呢?这非常值得研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96871613250, createdName=medcardio, createdTime=Wed Sep 16 10:20:00 CST 2015, time=2015-09-16, status=1, ipAttribution=)]
    2015-09-16 medcardio

    这其实背后还有一个原因,亚洲人的卒中,糖尿病,高血压,明显都偏年轻,那么到底是什么原因呢?这非常值得研究

    0

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