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Ann Intern Med:2型糖尿病的筛查真的有必要吗?

2015-05-09 Liang Huaibin 译 MedSci原创

众所周知,2型糖尿病的筛查可以更早的识别IFG(空腹血糖受损)、IGT糖耐量异常以及无症状糖尿病患者并对其进行治疗。为更新2008年美国预防服务工作组(the U.S. Preventive Services Task Force,USPSTF)制定的糖尿病筛查综述,USPSTF修改并撰写了新的综述,近日发表在《内科学年鉴》(Ann Intern Med)上。研究者发现在两项长期随访的实验中,和无

众所周知,2型糖尿病筛查可以更早的识别IFG(空腹血糖受损)、IGT糖耐量异常以及无症状糖尿病患者并对其进行治疗。为更新2008年美国预防服务工作组(the U.S. Preventive Services Task Force,USPSTF)制定的糖尿病筛查综述,USPSTF修改并撰写了新的综述,近日发表在《内科学年鉴》(Ann Intern Med)上。

研究者发现在两项长期随访的实验中,和无筛查人群组相比,糖尿病筛查对于减轻10年内病死率并无明确的收益:优势比为1.06 [95% CI, 0.90 to 1.25]。来源于16项的实验结果一致发现针对IGT或IFG患者,提前给予治疗可延迟糖尿病的进展,但绝大多数研究一致揭示出:筛查并不能降低被筛查人群的全因死亡率和心血管疾病死亡率。仅仅只有一项研究证实筛查后生活方式调整可以降低23年内受筛人群的全因死亡率和心血管疾病死亡率。而对于筛查出来的糖尿病患者,一项研究证实,和标准对照组相比,集中的多因素干预方法并不能降低这些人群的全因死亡率或心血管疾病死亡率。没有被筛查出来的确证糖尿病患者,从基于9个研究得出的结论来看:集中的血糖控制并不能降低全因死亡率或心血管疾病死亡率。不同研究就集中的血压控制能否降低上述不良风险得出的结论并不一致。

研究者得出结论:糖尿病筛查并不会降低受筛人群的十年内病死率。仍需要更多的研究来证实对筛查出的糖尿病患者进行治疗的确切有效性。但是筛查并不是完全没有益处:筛查对于延迟IGT、IFG患者的糖尿病发病时间和延缓疾病进展有一定好处。

原始出处:

Shelley Selph, MD, MPH; Tracy Dana, MLS; Ian Blazina, MPH; Christina Bougatsos, MPH; Hetal Patel, MD; and Roger Chou, MD  Screening for Type 2 Diabetes Mellitus: A Systematic Review for the U.S. Preventive Services Task Force  Ann Intern Med.  Published online 14 April 2015 doi:10.7326/M14-2221

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  1. [GetPortalCommentsPageByObjectIdResponse(id=24652, encodeId=2d67246525b, content=早期筛查有助于提高警惕,改变不良生活方式, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66201623811, createdName=900311song, createdTime=Sun May 24 10:25:00 CST 2015, time=2015-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24413, encodeId=339a244132f, content=收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b64e106775, createdName=cement123, createdTime=Thu May 21 13:26:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23462, encodeId=f8e6234627d, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed May 13 21:26:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23282, encodeId=c0e82328236, content=赞?, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKT7Exm9wh9wsVDUxNuicyfcsIlwSMQjeu0bnzjBBXuXgCq0GxthROPNEmfhfLpCZC3qDjpSK7LeyA/132, createdBy=67811617930, createdName=dreamslink, createdTime=Wed May 13 11:19:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606498, encodeId=6ddd160649833, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon May 11 13:43:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23081, encodeId=e451230811b, content=定期体检尤为重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Sun May 10 09:34:00 CST 2015, time=2015-05-10, status=1, ipAttribution=)]
    2015-05-24 900311song

    早期筛查有助于提高警惕,改变不良生活方式

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=24652, encodeId=2d67246525b, content=早期筛查有助于提高警惕,改变不良生活方式, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66201623811, createdName=900311song, createdTime=Sun May 24 10:25:00 CST 2015, time=2015-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24413, encodeId=339a244132f, content=收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b64e106775, createdName=cement123, createdTime=Thu May 21 13:26:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23462, encodeId=f8e6234627d, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed May 13 21:26:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23282, encodeId=c0e82328236, content=赞?, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKT7Exm9wh9wsVDUxNuicyfcsIlwSMQjeu0bnzjBBXuXgCq0GxthROPNEmfhfLpCZC3qDjpSK7LeyA/132, createdBy=67811617930, createdName=dreamslink, createdTime=Wed May 13 11:19:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606498, encodeId=6ddd160649833, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon May 11 13:43:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23081, encodeId=e451230811b, content=定期体检尤为重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Sun May 10 09:34:00 CST 2015, time=2015-05-10, status=1, ipAttribution=)]
    2015-05-21 cement123

    收藏了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=24652, encodeId=2d67246525b, content=早期筛查有助于提高警惕,改变不良生活方式, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66201623811, createdName=900311song, createdTime=Sun May 24 10:25:00 CST 2015, time=2015-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24413, encodeId=339a244132f, content=收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b64e106775, createdName=cement123, createdTime=Thu May 21 13:26:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23462, encodeId=f8e6234627d, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed May 13 21:26:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23282, encodeId=c0e82328236, content=赞?, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKT7Exm9wh9wsVDUxNuicyfcsIlwSMQjeu0bnzjBBXuXgCq0GxthROPNEmfhfLpCZC3qDjpSK7LeyA/132, createdBy=67811617930, createdName=dreamslink, createdTime=Wed May 13 11:19:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606498, encodeId=6ddd160649833, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon May 11 13:43:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23081, encodeId=e451230811b, content=定期体检尤为重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Sun May 10 09:34:00 CST 2015, time=2015-05-10, status=1, ipAttribution=)]
    2015-05-13 huaxipanxing

    看看

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=24652, encodeId=2d67246525b, content=早期筛查有助于提高警惕,改变不良生活方式, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66201623811, createdName=900311song, createdTime=Sun May 24 10:25:00 CST 2015, time=2015-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24413, encodeId=339a244132f, content=收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b64e106775, createdName=cement123, createdTime=Thu May 21 13:26:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23462, encodeId=f8e6234627d, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed May 13 21:26:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23282, encodeId=c0e82328236, content=赞?, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKT7Exm9wh9wsVDUxNuicyfcsIlwSMQjeu0bnzjBBXuXgCq0GxthROPNEmfhfLpCZC3qDjpSK7LeyA/132, createdBy=67811617930, createdName=dreamslink, createdTime=Wed May 13 11:19:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606498, encodeId=6ddd160649833, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon May 11 13:43:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23081, encodeId=e451230811b, content=定期体检尤为重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Sun May 10 09:34:00 CST 2015, time=2015-05-10, status=1, ipAttribution=)]
    2015-05-13 dreamslink

    赞?

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=24652, encodeId=2d67246525b, content=早期筛查有助于提高警惕,改变不良生活方式, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66201623811, createdName=900311song, createdTime=Sun May 24 10:25:00 CST 2015, time=2015-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24413, encodeId=339a244132f, content=收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b64e106775, createdName=cement123, createdTime=Thu May 21 13:26:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23462, encodeId=f8e6234627d, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed May 13 21:26:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23282, encodeId=c0e82328236, content=赞?, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKT7Exm9wh9wsVDUxNuicyfcsIlwSMQjeu0bnzjBBXuXgCq0GxthROPNEmfhfLpCZC3qDjpSK7LeyA/132, createdBy=67811617930, createdName=dreamslink, createdTime=Wed May 13 11:19:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606498, encodeId=6ddd160649833, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon May 11 13:43:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23081, encodeId=e451230811b, content=定期体检尤为重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Sun May 10 09:34:00 CST 2015, time=2015-05-10, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=24652, encodeId=2d67246525b, content=早期筛查有助于提高警惕,改变不良生活方式, beContent=null, objectType=article, channel=null, level=null, likeNumber=200, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66201623811, createdName=900311song, createdTime=Sun May 24 10:25:00 CST 2015, time=2015-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24413, encodeId=339a244132f, content=收藏了, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b64e106775, createdName=cement123, createdTime=Thu May 21 13:26:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23462, encodeId=f8e6234627d, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=123, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Wed May 13 21:26:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23282, encodeId=c0e82328236, content=赞?, beContent=null, objectType=article, channel=null, level=null, likeNumber=152, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKT7Exm9wh9wsVDUxNuicyfcsIlwSMQjeu0bnzjBBXuXgCq0GxthROPNEmfhfLpCZC3qDjpSK7LeyA/132, createdBy=67811617930, createdName=dreamslink, createdTime=Wed May 13 11:19:00 CST 2015, time=2015-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606498, encodeId=6ddd160649833, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon May 11 13:43:00 CST 2015, time=2015-05-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=23081, encodeId=e451230811b, content=定期体检尤为重要, beContent=null, objectType=article, channel=null, level=null, likeNumber=154, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=9e0b1603164, createdName=lovejing, createdTime=Sun May 10 09:34:00 CST 2015, time=2015-05-10, status=1, ipAttribution=)]
    2015-05-10 lovejing

    定期体检尤为重要

    0

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