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Int J Cardiol:房颤和2型糖尿病患者抗血栓治疗的差距

2019-04-30 xing.T 网络

由此可见,尽管有明确的指南建议进行抗凝治疗,但几乎一半的高危AF糖尿病和ASCVD患者未接受抗凝治疗,突出了在临床实践中管理这些患者临床改进的挑战和潜力。

近日,血管领域权威杂志International Journal of Cardiology上发表了一篇研究文章,研究人员旨在调查西他列汀血管结局评估试验(TECOS)中招募的患有心房颤动(AF)、2型糖尿病和已知的动脉粥样硬化性心血管疾病(ASCVD)的患者基线时使用不同抗血栓治疗方法。

具有AF病史的TECOS参与者通过CHA2DS2-VASc评分进行分层并评估其抗血栓形成方法。在调整关键基线特征后,采用Cox比例风险模型来探究AF病史与预先指定的临床结局之间可能的关联。

在14671名TECOS参与者中,1167名(8%)参与者有房颤史,其中51.6%的参与者使用维生素K拮抗剂(VKA); 31.2%的参与者单独使用VKA,16.9%的参与者使用阿司匹林加VKA,1.8%的参与者使用氯吡格雷加VKA,1.7%的参与者使用阿司匹林和氯吡格雷加VKA。使用阿司匹林的比例为56.8%:30.9%的参与者单独使用阿司匹林和7.3%的参与者使用阿司匹林加氯吡格雷。氯吡格雷单独使用比例为2.9%,7.3%的参与者未使用任何抗血栓药物。有房颤史的参与者比没有房颤的患者有更高的心血管事件风险,包括心力衰竭住院和全因死亡率。患有心肌梗死、心力衰竭、外周动脉疾病或既往卒中的白人、老年男性比没有这些特征的其他人更容易发生新发AF。

由此可见,尽管有明确的指南建议进行抗凝治疗,但几乎一半的高危AF糖尿病和ASCVD患者未接受抗凝治疗,突出了在临床实践中管理这些患者临床改进的挑战和潜力。

原始出处:

Patrícia O.Guimarães,et al.Antithrombotic treatment gap among patients with atrial fibrillation and type 2 diabete.International Journal of Cardiology.2019.https://www.sciencedirect.com/science/article/pii/S0167527319305819

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    2019-05-13 zwjnj2

    努力学习天天学习认真学习

    0

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    2019-05-02 smartxiuxiu

    0

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  5. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Tue Apr 30 21:50:38 CST 2019, time=2019-04-30, status=1, ipAttribution=)]
  6. 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  7. 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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Tue Apr 30 21:50:38 CST 2019, time=2019-04-30, status=1, ipAttribution=)]
    2019-05-02 gwc388
  8. 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encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Thu May 02 12:16:00 CST 2019, time=2019-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574124, encodeId=dfbd15e412403, content=<a href='/topic/show?id=ee4955e5730' target=_blank style='color:#2F92EE;'>#抗血栓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55757, encryptionId=ee4955e5730, topicName=抗血栓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a26516008049, createdName=gwc388, createdTime=Thu May 02 12:16:00 CST 2019, time=2019-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365579, encodeId=97a33655e951, content=学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed May 01 19:20:25 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042406, encodeId=6941104240686, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed May 01 00:16:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365536, encodeId=ac3d365536a1, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Tue Apr 30 21:50:38 CST 2019, time=2019-04-30, status=1, ipAttribution=)]
    2019-05-01 天地飞扬

    学习了,谢谢分享!

    0

  9. 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encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Thu May 02 12:16:00 CST 2019, time=2019-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1574124, encodeId=dfbd15e412403, content=<a href='/topic/show?id=ee4955e5730' target=_blank style='color:#2F92EE;'>#抗血栓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55757, encryptionId=ee4955e5730, topicName=抗血栓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a26516008049, createdName=gwc388, createdTime=Thu May 02 12:16:00 CST 2019, time=2019-05-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365579, encodeId=97a33655e951, content=学习了,谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=105, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed May 01 19:20:25 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042406, encodeId=6941104240686, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed May 01 00:16:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365536, encodeId=ac3d365536a1, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Tue Apr 30 21:50:38 CST 2019, time=2019-04-30, status=1, ipAttribution=)]
    2019-05-01 misszhang

    谢谢MedSci提供最新的资讯

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Wed May 01 19:20:25 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042406, encodeId=6941104240686, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Wed May 01 00:16:00 CST 2019, time=2019-05-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=365536, encodeId=ac3d365536a1, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160304/IMG56D94856B1B5D6405.jpg, createdBy=27931687771, createdName=一个字-牛, createdTime=Tue Apr 30 21:50:38 CST 2019, time=2019-04-30, status=1, ipAttribution=)]
    2019-04-30 一个字-牛

    学习了谢谢分享

    0

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