Oncotarget：Elenagen疫苗在晚期实体瘤治疗中表现安全性和抗肿瘤活性，并能恢复肿瘤对化学疗法的敏感性

2017-06-02 MedSci MedSci原创

Elenagen在晚期的实体瘤中表现出良好的安全性和抗肿瘤活性,而该项研究中另一特别令人鼓舞的方面是其还能恢复肿瘤对化学疗法的敏感性。

Elenagen是一种编码p62/SQSTM1的质粒，其第一类DNA疫苗具有两个相互补充的作用机制：能够引发针对p62的免疫应答并能缓解全身的慢性炎症。在以前对啮齿动物肿瘤模型和犬的自发性肿瘤研究中，Elenagen就表现出安全性和抗肿瘤功效。

目前的这项联合研究评估了Elenagen在晚期癌症的人类患者中的安全性和临床活性。研究中有15例患者接受不断增加剂量（每剂量1-5mg，每周5次）的Elenagen治疗，另外12例患者接受1mg剂量的Elenagen治疗。他们中10例患有乳腺癌和卵巢癌患者在Elenagen治疗后进行常规化学疗法治疗。其中，患有乳腺癌、卵巢癌、肺癌、肾癌和黑色素瘤的12例患者（44%）病情达到稳定超过8周，并且其中4例（15％）患者的肿瘤得到控制超过24周，甚至最多的达到32周。在Elenagen治疗后用常规化学疗法治疗的乳腺癌和卵巢癌患者获得了额外的12-28周的肿瘤稳定。

Elenagen在晚期的实体瘤中表现出良好的安全性和抗肿瘤活性,而该项研究中另一特别令人鼓舞的方面是其还能恢复肿瘤对化学疗法的敏感性。

原始出处：

Ponomarenko， D. M., et al. Safety and efficacy of p62 DNA vaccine ELENAGEN in a first-in-human trial in patients with advanced solid tumors. Oncotarget. 2017 Mar 25. doi：10.18632/oncotarget.16574

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2018-04-01 闆锋旦

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2017-12-05 医者仁心

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2017-10-17 chg121

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2017-06-04 ms5236388012055669

#敏感性#

135 0
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2017-06-04 446798725_87912766

#晚期实体瘤#

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肿瘤科

Oncotarget：Elenagen疫苗在晚期实体瘤治疗中表现安全性和抗肿瘤活性，并能恢复肿瘤对化学疗法的敏感性

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