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Clinica Chimica Acta:代谢综合征患者IL-10与冠心病严重程度的关系

2019-09-22 gladiator MedSci原创

代谢综合征是增加心脏病风险的危险因素。IL-10在MetS患者冠状动脉疾病(CAD)严重程度中的作用尚不清楚。我们研究了伴有或不伴有严重冠心病的MetS患者血浆中IL-10和其他促炎细胞因子的水平。 <span style="font-size:12.0pt;mso-bidi-font-size:14.0pt; font-family:宋体;mso-ascii-font-family:Ca

代谢综合征是增加心脏病风险的危险因素。IL-10MetS患者冠状动脉疾病(CAD)严重程度中的作用尚不清楚。我们研究了伴有或不伴有严重冠心病的MetS患者血浆中IL-10和其他促炎细胞因子的水平。

研究人员对健康和MetS个体进行横断面研究。对90例患者的IL-10和其他炎性白细胞介素进行了分析。组1N = 30),患有无严重CAD代谢综合征;组2n = 30),患有代谢综合征和严重CAD(心肌梗塞或血管重建术的历史通过手术或经皮经腔冠状血管成形术用或不用支架置入执行);组3N = 30)为健康个体。

研究显示,与第2组相比,第1IL-12p= 0.018),TNF-αp= 0.007)和IL-6的水平(p = 0.010)显著较高。与第2组和第3组相比,组2IL-10水平显著较高。仅IL-10的的水平可解释 严重CAD,并在逻辑回归模型作为保护因子(OR0.896; 95CI0.818-0.981)。

研究表明METs患者中较高的IL-10水平与较低的严重CAD发生率相关,这表明即使在促炎细胞因子水平较高的情况下,其抗炎活性也具有保护作用。

原始出处:

Ana Letícia Vargas BarcelosEduardo Aires de OliveiraAssociation of IL-10 to coronary disease severity in patients with metabolic syndrome

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    2020-02-25 windight
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    2019-09-24 jjjiang0202
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