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Clinical Infectious Diseases:孕妇接种季节性流感疫苗可使死胎率减半

2016-04-01 MedSci MedSci原创

在美国,死胎的发生率约为1%,每年约有24000个婴儿胎死腹中。 虽然导致死胎的具体原因尚不清楚,但研究人员认为,胎儿出生缺陷、胎盘功能障碍和脐带遗传问题及母亲疾病等因素也起到了一定作用。 35岁以上、孕期吸烟、孕妇肥胖或既往发生流产或或多胎妊娠的孕妇发生死产的风险更大。由于孕妇发生死产的原因无法确定,因此医生建议孕妇采用预防性保护策略。在一项新的研究中,Annette Regan博士和同事对澳大

在美国,死胎的发生率约为1%,每年约有24000个婴儿胎死腹中。

虽然导致死胎的具体原因尚不清楚,但研究人员认为,胎儿出生缺陷、胎盘功能障碍和脐带遗传问题及母亲疾病等因素也起到了一定作用。

35岁以上、孕期吸烟、孕妇肥胖或既往发生流产或或多胎妊娠的孕妇发生死产的风险更大。由于孕妇发生死产的原因无法确定,因此医生建议孕妇采用预防性保护策略。

在一项新的研究中,Annette Regan博士和同事对澳大利亚2012年4月-2013年12月间出生的功58008名孕妇的分娩结果进行了分析。其中52932名孕妇接种了季节性流感疫苗,而5076名孕妇未接种季节性流感疫苗。

研究人员发现,相比未接种季节性流感疫苗的孕妇而言,接种季节性流感疫苗的孕妇发生死产率的风险降低51%。

此外,研究人员发现,在接种流感疫苗后孕妇死产率会稍升高,之后下降,但他们注意到这并不具有统计学意义。但他们认为定期接种季节性流感疫苗可降低孕妇死产率。

Regan认为,2009年H1N1流行时期,他们也发现了类似的现象。这令他们十分欣喜。但是由于近40%的孕妇未接种流感疫苗,因此,她们发生死产的风险增加。

CDC)建议年龄大于6个月(包括孕妇)的民众都应每年接种流感疫苗。

孕妇患流感后出现会出现肺炎、支气管炎、鼻窦炎和耳部感染等并发症,发生不良妊娠结果的风险包括早产和胎儿死亡的风险也会增加。

然而,尽管CDC指出怀孕期间流感疫苗是安全的,许多孕妇仍然担心它可能对孩子造成伤害。但他们表示仍需进行更进一步的研究。

原始出处:

Stillbirth risk could be halved with seasonal flu shot during pregnancy,MNT,1,Apr,2016

Seasonal Trivalent Influenza Vaccination During Pregnancy and the Incidence of Stillbirth: Population-Based Retrospective Cohort Study, Annette K. Regan et al., Clinical Infectious Diseases, 30 March 2016

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    2016-04-03 30397606
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    2016-04-03 zll0628
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  6. [GetPortalCommentsPageByObjectIdResponse(id=2012085, encodeId=4bc42012085d9, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Oct 27 08:34:00 CST 2016, time=2016-10-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1468654, encodeId=b94c146865492, content=<a href='/topic/show?id=a19b4540688' target=_blank style='color:#2F92EE;'>#季节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45406, encryptionId=a19b4540688, topicName=季节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=cf986929326, createdName=30397606, createdTime=Sun Apr 03 13:34:00 CST 2016, time=2016-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1507618, encodeId=ef87150e618a6, content=<a href='/topic/show?id=8764484014' target=_blank style='color:#2F92EE;'>#clinical#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4840, encryptionId=8764484014, topicName=clinical)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1ee59933733, createdName=zll0628, createdTime=Sun Apr 03 13:34:00 CST 2016, time=2016-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508413, encodeId=c7a9150841363, content=<a href='/topic/show?id=0bc66341438' target=_blank style='color:#2F92EE;'>#死胎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=63414, encryptionId=0bc66341438, topicName=死胎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=cd2a9955567, createdName=bsmagic9135, createdTime=Sun Apr 03 13:34:00 CST 2016, time=2016-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533396, encodeId=c1481533396e8, content=<a href='/topic/show?id=fe21454096b' target=_blank style='color:#2F92EE;'>#季节性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45409, encryptionId=fe21454096b, topicName=季节性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Apr 03 13:34:00 CST 2016, time=2016-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1541700, encodeId=4f151541e0014, content=<a href='/topic/show?id=d6e6599e27' target=_blank style='color:#2F92EE;'>#Diseases#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5997, encryptionId=d6e6599e27, topicName=Diseases)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=474713318057, createdName=Tamikia, createdTime=Sun Apr 03 13:34:00 CST 2016, time=2016-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1569691, encodeId=4d34156969184, content=<a href='/topic/show?id=49e0161680c' target=_blank style='color:#2F92EE;'>#SES#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16168, encryptionId=49e0161680c, topicName=SES)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6fc215562628, createdName=dongjia2015, createdTime=Sun Apr 03 13:34:00 CST 2016, time=2016-04-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1591024, encodeId=f5ed15910243a, content=<a href='/topic/show?id=fe4a4541460' target=_blank style='color:#2F92EE;'>#季节性流感#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45414, encryptionId=fe4a4541460, topicName=季节性流感)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4d9717894537, createdName=sjzlzc013, createdTime=Sun Apr 03 13:34:00 CST 2016, time=2016-04-03, status=1, ipAttribution=)]
    2016-04-03 Tamikia
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    2016-04-03 dongjia2015
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