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Arthritis Rheumatol:内脏性肥胖与疼痛相关,但与结构性骨关节炎无关

2020-02-23 xiangting MedSci原创

内脏脂肪与肌肉骨骼和广泛性疼痛的风险升高相关。

低度炎症使骨关节炎(OA)和疼痛都变得更重。这项研究探讨了作为炎性细胞因子和脂肪因子主要来源的内脏脂肪是否与膝部OA或肌肉骨骼疼痛的风险升高相关。

纳入年龄50-79岁、患有膝部骨关节炎或OA高危的多中心骨关节炎研究队列的成员,这些患者在基线时进行了全身DEXA扫描。在基线、30个月和60个月进行膝部X光片和MRIs检查,并要求患者对膝关节疼痛的严重程度进行评分,并使用人体模型确定关节疼痛的部位。研究人员使用DEXA扫描测量全身脂肪以及躯干、内脏脂肪和皮下脂肪。研究评估了脂肪库大小与结构性结局(偶发性放射学OAMRI软骨丢失和滑膜炎)以及疼痛结局(膝关节疼痛加重、疼痛关节数量和广泛性疼痛)的相关性。调整年龄、性别、种族、教育、吸烟、体育锻炼、BMI和抑郁症状后,进行回归分析。

基线时的2,961名参与者中,女性占60.7%;平均年龄为62.5岁,BMI30.5kg/m2。对协变量进行调整后,没有任何脂肪指标与结构性结局相关。但是,总脂肪和内脏脂肪与膝关节疼痛加重和广泛性疼痛呈正相关,而不是皮下脂肪。而内脏脂肪的数量与疼痛关节的数量相关。

内脏脂肪与肌肉骨骼和广泛性疼痛的风险升高相关。

原始出处:

Shanshan Li. Visceral adiposity is associated with pain, but not structural osteoarthritis. Arthritis Rheumatol. February 2020.

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    2020-12-05 lisa438
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    2020-02-25 lmm397
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    2020-02-25 zhaojie88
  6. [GetPortalCommentsPageByObjectIdResponse(id=1972699, encodeId=d51d19e2699c3, content=<a href='/topic/show?id=8a6a2e8839' target=_blank style='color:#2F92EE;'>#Arthritis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2788, encryptionId=8a6a2e8839, topicName=Arthritis)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Sun May 24 11:43:00 CST 2020, time=2020-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1805697, encodeId=37cc180569e7a, content=<a href='/topic/show?id=95eae859563' target=_blank style='color:#2F92EE;'>#结构性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=103, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=78595, encryptionId=95eae859563, topicName=结构性)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/C2EFD5CFB07FE291138AD4FD0C98E3DE/100, createdBy=e3d52500031, createdName=膀胱癌, createdTime=Mon Oct 12 23:43:00 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2026664, encodeId=826d202666486, content=<a href='/topic/show?id=e0b110159578' target=_blank style='color:#2F92EE;'>#骨关节#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101595, encryptionId=e0b110159578, topicName=骨关节)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=373b263, createdName=lisa438, createdTime=Sat Dec 05 12:43:00 CST 2020, time=2020-12-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1266111, encodeId=5af0126611138, content=<a href='/topic/show?id=57a53011364' target=_blank style='color:#2F92EE;'>#关节炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30113, encryptionId=57a53011364, topicName=关节炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f90281, createdName=lmm397, createdTime=Tue Feb 25 04:43:00 CST 2020, time=2020-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1357401, encodeId=ad42135e40174, content=<a href='/topic/show?id=b0702e84b9' target=_blank style='color:#2F92EE;'>#ART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2784, encryptionId=b0702e84b9, topicName=ART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue Feb 25 04:43:00 CST 2020, time=2020-02-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=379604, encodeId=e0e53e9604e4, content=好文章,感谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=217, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=43a21971117, createdName=njwbhuang, createdTime=Mon Feb 24 08:29:48 CST 2020, time=2020-02-24, status=1, ipAttribution=)]
    2020-02-24 njwbhuang

    好文章,感谢分享!

    0

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