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Gut:IBS患者粪便中细菌谱可预测对低FODMAP饮食的反应性!

2017-04-18 xing.T MedSci原创

由此可见,低FODMAP饮食,而不是传统的IBS饮食,可能对肠道菌群有显著的影响。对低FODMAP饮食干预的反应可由粪便中的细菌谱所预测。

饮食干预对肠道细菌的影响是不明确的。近日,消化病领域权威杂志Gut上发表了一篇研究文章,研究人员旨在明确不同的饮食是如何影响肠道细菌,并且明确肠道菌群谱是否可以预测干预的效应。

67例IBS患者被随机分为传统IBS(n=34)或低发酵低聚糖、双糖、单糖和多元醇(FODMAPs)(n=33)饮食4周。在筛查和干预期间记录了4天的食物摄入量。研究人员在干预前后收集了受试者的粪便样品和IBS症状严重程度评分(IBS-SSS)报告。研究人员采用粪便菌群失调试验(GA图失调试验)来评估细菌组成。按协议进行分析了61例微生物资料可用的患者。

对低FODMAP饮食有反应,而对传统的膳食干预无反应的受试者(IBS-SSS降低超过50)根据粪便细菌谱被从无应答受试者中区分出来。在对低FODMAP饮食无反应的受试者中在干预前后细菌的数量往往是较高,相比于应答者。在42%的患者中低FODMAP干预与失调指数(DI)评分的增加有关;而在33%的接受传统IBS饮食的患者中DI评分降低。在对低FODMAP饮食无反应同时对传统的膳食干预也无反应的受试者中,在基础时其DI评分比应答者要高。最后,在传统的IBS饮食与调查的细菌显著降低无关,低FODMAP饮食与患者降低的双歧杆菌和放线菌相关,并且与乳糖消耗相关。

由此可见,低FODMAP饮食,而不是传统的IBS饮食,可能对肠道菌群有显著的影响。对低FODMAP饮食干预的反应可由粪便中的细菌谱所预测。

原始出处:

Sean M P Bennet, et al. Multivariate modelling of faecal bacterial profiles of patients with IBS predicts responsiveness to a diet low in FODMAPs. Gut. 2017. http://gut.bmj.com/content/early/2017/04/17/gutjnl-2016-313128

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    2017-04-20 柳叶一刀
  4. [GetPortalCommentsPageByObjectIdResponse(id=1977742, encodeId=5bfb19e77427b, content=<a href='/topic/show?id=40e1e56610' target=_blank style='color:#2F92EE;'>#FODMAP饮食#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7566, encryptionId=40e1e56610, topicName=FODMAP饮食)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d521144, createdName=wrj0121, createdTime=Thu Jul 20 07:19:00 CST 2017, time=2017-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2022784, encodeId=71af2022e848f, content=<a href='/topic/show?id=188b3e7309c' target=_blank style='color:#2F92EE;'>#反应性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37730, encryptionId=188b3e7309c, topicName=反应性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d7532500500, createdName=12499e01m47暂无昵称, createdTime=Fri Jan 26 18:19:00 CST 2018, time=2018-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1307655, encodeId=8bb3130e6558e, content=<a href='/topic/show?id=04ab931993' target=_blank style='color:#2F92EE;'>#IBS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9319, encryptionId=04ab931993, topicName=IBS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=778d36, createdName=柳叶一刀, createdTime=Thu Apr 20 03:19:00 CST 2017, time=2017-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1466793, encodeId=08931466e9356, content=<a href='/topic/show?id=edd5e630426' target=_blank style='color:#2F92EE;'>#粪便#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76304, encryptionId=edd5e630426, topicName=粪便)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=03cc6863823, createdName=Homburg, createdTime=Thu Apr 20 03:19:00 CST 2017, time=2017-04-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=188717, encodeId=f3de188e171c, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28761705280, createdName=cuiyejia, createdTime=Wed Apr 19 08:20:43 CST 2017, time=2017-04-19, status=1, ipAttribution=)]
    2017-04-20 Homburg
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    2017-04-19 cuiyejia

    学习了,谢谢分享

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