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总结：心脏源性分泌物质（Cardiac Secretome）汇总

2013-04-11 MedSci MedSci原创

心脏内分泌
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    心脏不仅是一个动力器官，亦是一个内分泌组织，它可以产生和释放几百种生物活性物质。主要是多肽和蛋白质，总称为Cardiac Secretome。应用蛋白质组分析在细胞中约含20000多种蛋白质。目前鉴定出的分泌蛋白和多肽约有1000-2000种，约占细胞蛋白总数的 5-10%。在心肌细胞鉴定出的分泌蛋白，现在约有80-120多种，它们或有信号肽序列、或有穿膜Do

    心脏不仅是一个动力器官，亦是一个内分泌组织，它可以产生和释放几百种生物活性物质。主要是多肽和蛋白质，总称为Cardiac Secretome。应用蛋白质组分析在细胞中约含20000多种蛋白质。目前鉴定出的分泌蛋白和多肽约有1000-2000种，约占细胞蛋白总数的 5-10%。在心肌细胞鉴定出的分泌蛋白，现在约有80-120多种，它们或有信号肽序列、或有穿膜Domain，或有KDEL四种氨基酸的Motif 等。但确切的心肌分泌蛋白和多肽数目尚不清楚，目前多是一种估计。心源性分泌物质大体可分为以下三大类： 心源性激素和生长因子：如心钠素、脑钠素、血管紧张素、肾上腺髓质素、Intermedin、降钙素基因相关肽、BK、ET、阿片肽、VEGF、Apelin、Adiponectin、IGF、FGF、TGF-β等等。在体内主要起旁分泌和循环分泌作用。它们是维持和调节心血管功能和肾脏水钠平衡的主要活性物质。 心源性介质：亦称心源性细胞因子（Cardiokines或Cardiomyokines，ＣＫ或CMK），如TNF-α、白细胞介素、TGF-β、IL-6、MC

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    2014-03-08 ysjykql

    #RET#

    0

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    2013-12-25 ms9608593228839890

    #DIA#

    0

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    2013-07-25 gwc392

    #分泌#

    0

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    2013-10-16 heli0118

    #分泌物#

    0

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    2013-04-13 diushouji

    #ECR#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1913804, encodeId=4207191380485, content=<a href='/topic/show?id=4684153e41f' target=_blank style='color:#2F92EE;'>#RET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15374, encryptionId=4684153e41f, topicName=RET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=96d4340, createdName=ysjykql, createdTime=Sat Mar 08 06:59:00 CST 2014, time=2014-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1636641, encodeId=56c11636641f7, content=<a href='/topic/show?id=afda591646' target=_blank style='color:#2F92EE;'>#DIA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5916, encryptionId=afda591646, topicName=DIA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=987022654425, createdName=ms9608593228839890, createdTime=Wed Dec 25 13:59:00 CST 2013, time=2013-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682140, encodeId=fad41682140d1, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Thu Jul 25 13:59:00 CST 2013, time=2013-07-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041817, encodeId=4dec204181ece, content=<a href='/topic/show?id=9c7531e85c9' target=_blank style='color:#2F92EE;'>#分泌物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31785, encryptionId=9c7531e85c9, topicName=分泌物)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Wed Oct 16 08:59:00 CST 2013, time=2013-10-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1426449, encodeId=d1d41426449ce, content=<a href='/topic/show?id=afc96505af' target=_blank style='color:#2F92EE;'>#ECR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6505, encryptionId=afc96505af, topicName=ECR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=51824069026, createdName=diushouji, createdTime=Sat Apr 13 13:59:00 CST 2013, time=2013-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581445, encodeId=31c815814458e, content=<a href='/topic/show?id=2bc1519579' target=_blank style='color:#2F92EE;'>#CRE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5195, encryptionId=2bc1519579, topicName=CRE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4ca216802819, createdName=HinsMax, createdTime=Sat Apr 13 13:59:00 CST 2013, time=2013-04-13, status=1, ipAttribution=)]
    2013-04-13 HinsMax

    #CRE#

    0

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