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SBHA抑制人乳腺癌细胞增殖

2012-06-23 鲍爱宁摘编 医学论坛网

SBHA乳腺癌细胞增殖复旦大学肿瘤医院
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　　最近，复旦大学附属肿瘤医院闵行分院肿瘤内科、复旦大学附属肿瘤医院肿瘤内科、复旦大学上海医学院肿瘤学系的研究人员的一项研究显示，组蛋白去乙酰化酶抑制剂辛二酰双羟肟酸(suberic bishydroxamate，suberoyl bishydroxamic acid，SBHA)具有抑制人乳腺癌细胞增殖作用，使细胞阻滞在G0～G1期。 该研究发表于2012年

　　最近，复旦大学附属肿瘤医院闵行分院肿瘤内科、复旦大学附属肿瘤医院肿瘤内科、复旦大学上海医学院肿瘤学系的研究人员的一项研究显示，组蛋白去乙酰化酶抑制剂辛二酰双羟肟酸(suberic bishydroxamate，suberoyl bishydroxamic acid，SBHA)具有抑制人乳腺癌细胞增殖作用，使细胞阻滞在G0～G1期。 该研究发表于2012年第3期《中国癌症杂志》。

　　更多还原该研究旨在研究SBHA对人乳腺癌细胞增殖及周期的影响。

　　杨新苗等研究人员将不同浓度的SBHA以不同时间作用于乳腺癌MCF-7及MDA-MB-231细胞，用WST-8法检测其对细胞增殖能力的影响；用相差显微镜观察药物对细胞形态学变化；用流式细胞仪分析细胞周期。

　　 结果，SBHA呈时间和剂量依赖性抑制乳腺癌细胞增殖，使细胞形态发生明显变化，明显使G0～G1期细胞比例增高，S期细胞比例降低，与对照组比较差异有统计学意义(P>0.05)。
    

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1793641, encodeId=390f1e936418c, content=<a href='/topic/show?id=c4741593519' target=_blank style='color:#2F92EE;'>#SBHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15935, encryptionId=c4741593519, topicName=SBHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=322359, createdName=bioon3, createdTime=Tue Feb 12 21:47:00 CST 2013, time=2013-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701015, encodeId=082c1e0101562, content=<a href='/topic/show?id=7113e15237a' target=_blank style='color:#2F92EE;'>#癌细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71523, encryptionId=7113e15237a, topicName=癌细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3fb930318282, createdName=hywen7336, createdTime=Sat Oct 20 02:47:00 CST 2012, time=2012-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251893, encodeId=821a1251893e7, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon Jun 25 11:47:00 CST 2012, time=2012-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540860, encodeId=b57b1540860e2, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Mon Jun 25 11:47:00 CST 2012, time=2012-06-25, status=1, ipAttribution=)]
    2013-02-12 bioon3

    #SBHA#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1793641, encodeId=390f1e936418c, content=<a href='/topic/show?id=c4741593519' target=_blank style='color:#2F92EE;'>#SBHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15935, encryptionId=c4741593519, topicName=SBHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=322359, createdName=bioon3, createdTime=Tue Feb 12 21:47:00 CST 2013, time=2013-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701015, encodeId=082c1e0101562, content=<a href='/topic/show?id=7113e15237a' target=_blank style='color:#2F92EE;'>#癌细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71523, encryptionId=7113e15237a, topicName=癌细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3fb930318282, createdName=hywen7336, createdTime=Sat Oct 20 02:47:00 CST 2012, time=2012-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251893, encodeId=821a1251893e7, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon Jun 25 11:47:00 CST 2012, time=2012-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540860, encodeId=b57b1540860e2, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Mon Jun 25 11:47:00 CST 2012, time=2012-06-25, status=1, ipAttribution=)]
    2012-10-20 hywen7336

    #癌细胞增殖#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1793641, encodeId=390f1e936418c, content=<a href='/topic/show?id=c4741593519' target=_blank style='color:#2F92EE;'>#SBHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15935, encryptionId=c4741593519, topicName=SBHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=322359, createdName=bioon3, createdTime=Tue Feb 12 21:47:00 CST 2013, time=2013-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701015, encodeId=082c1e0101562, content=<a href='/topic/show?id=7113e15237a' target=_blank style='color:#2F92EE;'>#癌细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71523, encryptionId=7113e15237a, topicName=癌细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3fb930318282, createdName=hywen7336, createdTime=Sat Oct 20 02:47:00 CST 2012, time=2012-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251893, encodeId=821a1251893e7, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon Jun 25 11:47:00 CST 2012, time=2012-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540860, encodeId=b57b1540860e2, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Mon Jun 25 11:47:00 CST 2012, time=2012-06-25, status=1, ipAttribution=)]
    2012-06-25 yxch36

    #癌细胞#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1793641, encodeId=390f1e936418c, content=<a href='/topic/show?id=c4741593519' target=_blank style='color:#2F92EE;'>#SBHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15935, encryptionId=c4741593519, topicName=SBHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=322359, createdName=bioon3, createdTime=Tue Feb 12 21:47:00 CST 2013, time=2013-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1701015, encodeId=082c1e0101562, content=<a href='/topic/show?id=7113e15237a' target=_blank style='color:#2F92EE;'>#癌细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71523, encryptionId=7113e15237a, topicName=癌细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3fb930318282, createdName=hywen7336, createdTime=Sat Oct 20 02:47:00 CST 2012, time=2012-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251893, encodeId=821a1251893e7, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon Jun 25 11:47:00 CST 2012, time=2012-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1540860, encodeId=b57b1540860e2, content=<a href='/topic/show?id=ba2ee78630b' target=_blank style='color:#2F92EE;'>#细胞增殖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77863, encryptionId=ba2ee78630b, topicName=细胞增殖)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f58613291856, createdName=晓辰, createdTime=Mon Jun 25 11:47:00 CST 2012, time=2012-06-25, status=1, ipAttribution=)]
    2012-06-25 晓辰

    #细胞增殖#

    0

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